Leukocyte adhesion deficiency type 1 [Supplementary Concept]

An autosomal recessive form of leukocyte adhesion deficiency syndrome that results from a deficiency of the beta-2 integrin subunit (ITGB2 gene) of the leukocyte cell adhesion molecule which is present on the surface of peripheral blood MONONUCLEAR LEUKOCYTES and GRANULOCYTES and mediates cell-cell and cell-EXTRACELLULAR MATRIX adhesion. OMIM: 116920

Date introduced: August 25, 2010

MeSH Unique ID: C535887

Heading Mapped to:

• Leukocyte-Adhesion Deficiency Syndrome

Entry Terms:

• Leukocyte Adhesion Deficiency, Type I
• Lfa1 Immunodeficiency
• Lymphocyte function-associated antigen 1 immunodeficiency