Autophagy-Related Protein-1 Homolog
A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.
Year introduced: 2017
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Subheadings:
Tree Number(s): D08.811.913.696.620.682.700.108, D12.776.094.438, D12.776.476.563.108
MeSH Unique ID: D000071189
Registry Number: EC 2.7.11.1
Entry Terms:
- Autophagy Related Protein 1 Homolog
- Serine-Threonine Protein Kinase ULK1
- Serine Threonine Protein Kinase ULK1
- Unc-51 Like Autophagy Activating Kinase 1
- Unc 51 Like Autophagy Activating Kinase 1
- ULK1 Protein
- Unc-51-Like Kinase 1
- Unc 51 Like Kinase 1
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