MedGen

Spinocerebellar ataxia type 6 (SCA6) is characterized by adult-onset, slowly progressive cerebellar ataxia, dysarthria, and nystagmus. The age of onset ranges from 19 to 73 years; mean age of onset is between 43 and 52 years. Initial symptoms are gait unsteadiness, stumbling, and imbalance (in ~90%) and dysarthria (in ~10%). Eventually all persons have gait ataxia, upper-limb incoordination, intention tremor, and dysarthria. Dysphagia and choking are common. Visual disturbances may result from diplopia, difficulty fixating on moving objects, horizontal gaze-evoked nystagmus, and vertical nystagmus. Hyperreflexia and extensor plantar responses occur in up to 40%-50%. Basal ganglia signs, including dystonia and blepharospasm, occur in up to 25%. Mentation is generally preserved. [from GeneReviews]

Any migraine disorder in which the cause of the disease is a mutation in the KCNK18 gene. [from MONDO]

Migraine is a common complex disorder that shows strong familial aggregation. The disorder is generally characterized by chronic episodic headache usually associated with nausea and vomiting (summary by Nyholt et al., 1998). For a phenotypic description and discussion of genetic heterogeneity of migraine headaches, see MGR1 (157300). [from OMIM]

Advanced sleep phase syndrome is characterized by very early sleep onset and offset (summary by Jones et al., 1999). For a discussion of genetic heterogeneity of advanced sleep phase syndrome, see FASPS1 (604348). [from OMIM]

Migraine is a complex and heterogeneous disorder characterized by recurrent attacks of headache associated with autonomic and neurologic symptoms. Two primary types of migraine can be distinguished: migraine without aura and migraine with aura. Usually, 1 type of migraine prevails intraindividually. Migraine without aura (MO) is the more common form and is characterized by unilateral pulsating headache of moderate to severe intensity, lasting 4 to 72 hours. The attacks are associated with nausea, vomiting, and photo- and phonophobia and are aggravated by physical activity. Frequency, severity, and duration vary substantially (summary by Soragna et al., 2003). For a phenotypic description and discussion of genetic heterogeneity of migraine headaches, see MGR1 (157300). [from OMIM]

Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria [from HPO]