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Decreased proportion of CD4-positive helper T cells

MedGen UID:
1719772
•Concept ID:
C5235140
•
Finding
Synonym: Decreased number of CD4+ T cells

Recent clinical studies

Etiology

Recombinant human IL-37 attenuates acute cardiac allograft rejection in mice.
Shao B, Zhang JY, Ren SH, Qin YF, Wang HD, Gao YC, Kong DJ, Hu YH, Qin H, Li GM, Wang H
Cytokine 2024 Jul;179:156598. Epub 2024 Apr 8 doi: 10.1016/j.cyto.2024.156598. PMID: 38583255
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
The Impact of Anti-TNF Therapy on CD4+ and CD8+ Cell Subsets in Ankylosing Spondylitis.
Dulic S, Vasarhelyi Z, Bajnok A, Szalay B, Toldi G, Kovacs L, Balog A
Pathobiology 2018;85(3):201-210. Epub 2017 Dec 6 doi: 10.1159/000484250. PMID: 29212085
Clinical correlation of peripheral CD4+‑cell sub‑sets, their imbalance and Parkinson's disease.
Chen Y, Qi B, Xu W, Ma B, Li L, Chen Q, Qian W, Liu X, Qu H
Mol Med Rep 2015 Oct;12(4):6105-11. Epub 2015 Jul 29 doi: 10.3892/mmr.2015.4136. PMID: 26239429
Aging disturbs the balance between effector and regulatory CD4+ T cells.
van der Geest KS, Abdulahad WH, Tete SM, Lorencetti PG, Horst G, Bos NA, Kroesen BJ, Brouwer E, Boots AM
Exp Gerontol 2014 Dec;60:190-6. Epub 2014 Nov 7 doi: 10.1016/j.exger.2014.11.005. PMID: 25449852

Diagnosis

The abnormal expression of peripheral blood CD4+ T lymphocyte subsets are correlated with primary Sjögren's syndrome complicated with haematological involvement.
Li X, Zhang S, Cheng T, Wang J, Li F, Shi L, Li X
Clin Exp Rheumatol 2024 Dec;42(12):2412-2419. Epub 2024 Oct 25 doi: 10.55563/clinexprheumatol/st9u8m. PMID: 39480501
Immunosuppressive Effects of Two Probiotics, Lactobacillus paracasei DSM 13434 and Lactobacillus plantarum DSM 15312, on CD4+ T Cells of Multiple Sclerosis Patients.
Chakamian K, Robat-Jazi B, Naser Moghadasi A, Mansouri F, Nodehi M, Motevaseli E, Izad M, Yekaninejad S, Shirzad M, Bidad K, Oraei M, Ansaripour B, Saboor-Yaraghi AA
Iran J Allergy Asthma Immunol 2023 Feb 20;22(1):34-45. doi: 10.18502/ijaai.v22i1.12004. PMID: 37002629
The immune cell landscape of peripheral blood mononuclear cells from PNS patients.
Ye Q, Zhou C, Li S, Wang J, Liu F, Liu Z, Mao J, Fu H
Sci Rep 2021 Jun 22;11(1):13083. doi: 10.1038/s41598-021-92573-6. PMID: 34158604Free PMC Article
Reduced activated regulatory T cells and imbalance of Th17/activated Treg cells marks renal involvement in ANCA-associated vasculitis.
Wang Y, Zhang S, Zhang N, Feng M, Liang Z, Zhao X, Gao C, Qin Y, Wu Y, Liu G, Zhao J, Guo H, Luo J
Mol Immunol 2020 Feb;118:19-29. Epub 2019 Dec 26 doi: 10.1016/j.molimm.2019.11.010. PMID: 31837507
Decreased CD4(+)CD25(+)CD127(dim/-) Regulatory T Cells and T Helper 17 Cell Responsiveness to Toll-Like Receptor 2 in Chronic Hepatitis C Patients with Daclatasvir Plus Asunaprevir Therapy.
Wei K, Jiang BC, Guan JH, Zhang DN, Zhang MX, Wu JL, Zhu GZ
Viral Immunol 2018 Oct;31(8):559-567. Epub 2018 Aug 1 doi: 10.1089/vim.2018.0055. PMID: 30067145

Therapy

Ustekinumab Decreases Circulating Th17 Cells in Ulcerative Colitis.
Imazu N, Torisu T, Ihara Y, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Kitazono T
Intern Med 2024 Jan 15;63(2):153-158. Epub 2023 May 17 doi: 10.2169/internalmedicine.1724-23. PMID: 37197955Free PMC Article
Immunosuppressive Effects of Two Probiotics, Lactobacillus paracasei DSM 13434 and Lactobacillus plantarum DSM 15312, on CD4+ T Cells of Multiple Sclerosis Patients.
Chakamian K, Robat-Jazi B, Naser Moghadasi A, Mansouri F, Nodehi M, Motevaseli E, Izad M, Yekaninejad S, Shirzad M, Bidad K, Oraei M, Ansaripour B, Saboor-Yaraghi AA
Iran J Allergy Asthma Immunol 2023 Feb 20;22(1):34-45. doi: 10.18502/ijaai.v22i1.12004. PMID: 37002629
CD4+ T Cell Help Is Mandatory for Naive and Memory Donor-Specific Antibody Responses: Impact of Therapeutic Immunosuppression.
Chen CC, Koenig A, Saison C, Dahdal S, Rigault G, Barba T, Taillardet M, Chartoire D, Ovize M, Morelon E, Defrance T, Thaunat O
Front Immunol 2018;9:275. Epub 2018 Feb 19 doi: 10.3389/fimmu.2018.00275. PMID: 29515582Free PMC Article
The Impact of Anti-TNF Therapy on CD4+ and CD8+ Cell Subsets in Ankylosing Spondylitis.
Dulic S, Vasarhelyi Z, Bajnok A, Szalay B, Toldi G, Kovacs L, Balog A
Pathobiology 2018;85(3):201-210. Epub 2017 Dec 6 doi: 10.1159/000484250. PMID: 29212085
Aging disturbs the balance between effector and regulatory CD4+ T cells.
van der Geest KS, Abdulahad WH, Tete SM, Lorencetti PG, Horst G, Bos NA, Kroesen BJ, Brouwer E, Boots AM
Exp Gerontol 2014 Dec;60:190-6. Epub 2014 Nov 7 doi: 10.1016/j.exger.2014.11.005. PMID: 25449852

Prognosis

Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset.
Gutiérrez-Bautista JF, Rodriguez-Nicolas A, Rosales-Castillo A, Jiménez P, Garrido F, Anderson P, Ruiz-Cabello F, López-Ruz MÁ
Front Immunol 2020;11:596553. Epub 2020 Nov 26 doi: 10.3389/fimmu.2020.596553. PMID: 33324414Free PMC Article
CD4+ T Cell Help Is Mandatory for Naive and Memory Donor-Specific Antibody Responses: Impact of Therapeutic Immunosuppression.
Chen CC, Koenig A, Saison C, Dahdal S, Rigault G, Barba T, Taillardet M, Chartoire D, Ovize M, Morelon E, Defrance T, Thaunat O
Front Immunol 2018;9:275. Epub 2018 Feb 19 doi: 10.3389/fimmu.2018.00275. PMID: 29515582Free PMC Article
The Impact of Anti-TNF Therapy on CD4+ and CD8+ Cell Subsets in Ankylosing Spondylitis.
Dulic S, Vasarhelyi Z, Bajnok A, Szalay B, Toldi G, Kovacs L, Balog A
Pathobiology 2018;85(3):201-210. Epub 2017 Dec 6 doi: 10.1159/000484250. PMID: 29212085
T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy.
Dulic S, Vásárhelyi Z, Sava F, Berta L, Szalay B, Toldi G, Kovács L, Balog A
Mediators Inflamm 2017;2017:6894374. Epub 2017 Oct 25 doi: 10.1155/2017/6894374. PMID: 29209104Free PMC Article

Clinical prediction guides

Immunosuppressive Effects of Two Probiotics, Lactobacillus paracasei DSM 13434 and Lactobacillus plantarum DSM 15312, on CD4+ T Cells of Multiple Sclerosis Patients.
Chakamian K, Robat-Jazi B, Naser Moghadasi A, Mansouri F, Nodehi M, Motevaseli E, Izad M, Yekaninejad S, Shirzad M, Bidad K, Oraei M, Ansaripour B, Saboor-Yaraghi AA
Iran J Allergy Asthma Immunol 2023 Feb 20;22(1):34-45. doi: 10.18502/ijaai.v22i1.12004. PMID: 37002629
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
The immune cell landscape of peripheral blood mononuclear cells from PNS patients.
Ye Q, Zhou C, Li S, Wang J, Liu F, Liu Z, Mao J, Fu H
Sci Rep 2021 Jun 22;11(1):13083. doi: 10.1038/s41598-021-92573-6. PMID: 34158604Free PMC Article
CD4+ T Cell Help Is Mandatory for Naive and Memory Donor-Specific Antibody Responses: Impact of Therapeutic Immunosuppression.
Chen CC, Koenig A, Saison C, Dahdal S, Rigault G, Barba T, Taillardet M, Chartoire D, Ovize M, Morelon E, Defrance T, Thaunat O
Front Immunol 2018;9:275. Epub 2018 Feb 19 doi: 10.3389/fimmu.2018.00275. PMID: 29515582Free PMC Article
Clinical correlation of peripheral CD4+‑cell sub‑sets, their imbalance and Parkinson's disease.
Chen Y, Qi B, Xu W, Ma B, Li L, Chen Q, Qian W, Liu X, Qu H
Mol Med Rep 2015 Oct;12(4):6105-11. Epub 2015 Jul 29 doi: 10.3892/mmr.2015.4136. PMID: 26239429

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