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Aspergillosis

MedGen UID:
13939
Concept ID:
C0004030
Disease or Syndrome
Synonyms: Aspergilloses; Aspergillus Infection; Aspergillus Infections; Infection, Aspergillus; Infections, Aspergillus
SNOMED CT: Aspergillosis (65553006); Infection due to Aspergillus (65553006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005657
Orphanet: ORPHA1163

Definition

A rare infectious disease caused by inhalation of the opportunistic fungus <i>aspergillus</i> that can lead to the following manifestations: allergic bronchopulmonary aspergillosis (ABPA), aspergilloma, chronic necrotizing pulmonary aspergillosis (CNPA), and invasive aspergillosis (IA). Aspergilloma occurs in patients with cavitary lung disease and results in a fungal mass with variable clinical presentations from asymptomatic to life-threatening (massive hemoptysis). CNPA manifests as subacute pneumonia in patients with underlying disease. IA is disseminated aspergillosis that eventually invades other organs. Cutaneous aspergillosis is usually the dermatological manifestation of IA that manifests as erythematous-to-violaceous plaques or papules, often characterized by a central necrotic ulcer or eschar. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAspergillosis
Follow this link to review classifications for Aspergillosis in Orphanet.

Professional guidelines

PubMed

Douglas AP, Smibert OC, Bajel A, Halliday CL, Lavee O, McMullan B, Yong MK, van Hal SJ, Chen SC; Australasian Antifungal Guidelines Steering Committee
Intern Med J 2021 Nov;51 Suppl 7:143-176. doi: 10.1111/imj.15591. PMID: 34937136
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Patterson TF, Thompson GR 3rd, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE
Clin Infect Dis 2016 Aug 15;63(4):e1-e60. Epub 2016 Jun 29 doi: 10.1093/cid/ciw326. PMID: 27365388Free PMC Article

Recent clinical studies

Etiology

Machado M, Fortún J, Muñoz P
Med Clin (Barc) 2024 Aug 30;163(4):189-198. Epub 2024 May 6 doi: 10.1016/j.medcli.2024.01.045. PMID: 38714471
Earle K, Valero C, Conn DP, Vere G, Cook PC, Bromley MJ, Bowyer P, Gago S
Virulence 2023 Dec;14(1):2172264. doi: 10.1080/21505594.2023.2172264. PMID: 36752587Free PMC Article
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Agarwal R, Sehgal IS, Dhooria S, Muthu V, Prasad KT, Bal A, Aggarwal AN, Chakrabarti A
Indian J Med Res 2020 Jun;151(6):529-549. doi: 10.4103/ijmr.IJMR_1187_19. PMID: 32719226Free PMC Article
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957

Diagnosis

Machado M, Fortún J, Muñoz P
Med Clin (Barc) 2024 Aug 30;163(4):189-198. Epub 2024 May 6 doi: 10.1016/j.medcli.2024.01.045. PMID: 38714471
Janssens I, Lambrecht BN, Van Braeckel E
Semin Respir Crit Care Med 2024 Feb;45(1):3-20. Epub 2024 Jan 29 doi: 10.1055/s-0043-1777259. PMID: 38286136Free PMC Article
Agarwal R, Muthu V, Sehgal IS, Dhooria S, Prasad KT, Aggarwal AN
Clin Chest Med 2022 Mar;43(1):99-125. doi: 10.1016/j.ccm.2021.12.002. PMID: 35236565
Thompson GR 3rd, Young JH
N Engl J Med 2021 Oct 14;385(16):1496-1509. doi: 10.1056/NEJMra2027424. PMID: 34644473
Patterson TF, Thompson GR 3rd, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE
Clin Infect Dis 2016 Aug 15;63(4):e1-e60. Epub 2016 Jun 29 doi: 10.1093/cid/ciw326. PMID: 27365388Free PMC Article

Therapy

Douglas AP, Smibert OC, Bajel A, Halliday CL, Lavee O, McMullan B, Yong MK, van Hal SJ, Chen SC; Australasian Antifungal Guidelines Steering Committee
Intern Med J 2021 Nov;51 Suppl 7:143-176. doi: 10.1111/imj.15591. PMID: 34937136
Tissot F, Agrawal S, Pagano L, Petrikkos G, Groll AH, Skiada A, Lass-Flörl C, Calandra T, Viscoli C, Herbrecht R
Haematologica 2017 Mar;102(3):433-444. Epub 2016 Dec 23 doi: 10.3324/haematol.2016.152900. PMID: 28011902Free PMC Article
Marr KA, Schlamm HT, Herbrecht R, Rottinghaus ST, Bow EJ, Cornely OA, Heinz WJ, Jagannatha S, Koh LP, Kontoyiannis DP, Lee DG, Nucci M, Pappas PG, Slavin MA, Queiroz-Telles F, Selleslag D, Walsh TJ, Wingard JR, Maertens JA
Ann Intern Med 2015 Jan 20;162(2):81-9. doi: 10.7326/M13-2508. PMID: 25599346
Schwartze VU, Jacobsen ID
Mycoses 2014 Dec;57 Suppl 3:73-8. Epub 2014 Sep 3 doi: 10.1111/myc.12239. PMID: 25186921
Kauffman CA, Malani AN, Easley C, Kirkpatrick P
Nat Rev Drug Discov 2007 Mar;6(3):183-4. doi: 10.1038/nrd2270. PMID: 17396290

Prognosis

Denning DW
Lancet Infect Dis 2024 Jul;24(7):e428-e438. Epub 2024 Jan 12 doi: 10.1016/S1473-3099(23)00692-8. PMID: 38224705
Zarif A, Thomas A, Vayro A
Yale J Biol Med 2021 Dec;94(4):673-679. Epub 2021 Dec 29 PMID: 34970105Free PMC Article
Tripathi M, Mohindra S
Lancet 2018 Sep 8;392(10150):e8. doi: 10.1016/S0140-6736(18)31949-4. PMID: 30215384
Denning DW, Kneale M, Sobel JD, Rautemaa-Richardson R
Lancet Infect Dis 2018 Nov;18(11):e339-e347. Epub 2018 Aug 2 doi: 10.1016/S1473-3099(18)30103-8. PMID: 30078662
Yousaf M, Medford AR
QJM 2013 Jul;106(7):675-6. Epub 2012 Jun 28 doi: 10.1093/qjmed/hcs118. PMID: 22753668

Clinical prediction guides

Lass-Flörl C, Steixner S
Mol Aspects Med 2023 Dec;94:101215. Epub 2023 Oct 5 doi: 10.1016/j.mam.2023.101215. PMID: 37804792
Jin M, Douglass JA, Elborn JS, Agarwal R, Calhoun WJ, Lazarewicz S, Jaumont X, Yan M
J Allergy Clin Immunol Pract 2023 Mar;11(3):896-905. Epub 2022 Dec 26 doi: 10.1016/j.jaip.2022.12.012. PMID: 36581073
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Park SY, Yoon JA, Kim SH
Korean J Intern Med 2017 Sep;32(5):805-812. Epub 2017 Aug 24 doi: 10.3904/kjim.2017.109. PMID: 28835093Free PMC Article
Kousha M, Tadi R, Soubani AO
Eur Respir Rev 2011 Sep 1;20(121):156-74. doi: 10.1183/09059180.00001011. PMID: 21881144Free PMC Article

Recent systematic reviews

Gioia F, Walti LN, Orchanian-Cheff A, Husain S
Lancet Respir Med 2024 Mar;12(3):207-216. Epub 2024 Jan 4 doi: 10.1016/S2213-2600(23)00408-3. PMID: 38185135
Jin M, Douglass JA, Elborn JS, Agarwal R, Calhoun WJ, Lazarewicz S, Jaumont X, Yan M
J Allergy Clin Immunol Pract 2023 Mar;11(3):896-905. Epub 2022 Dec 26 doi: 10.1016/j.jaip.2022.12.012. PMID: 36581073
Kariyawasam RM, Dingle TC, Kula BE, Vandermeer B, Sligl WI, Schwartz IS
Clin Microbiol Infect 2022 Jul;28(7):920-927. Epub 2022 Feb 10 doi: 10.1016/j.cmi.2022.01.027. PMID: 35150878Free PMC Article
Fumagalli J, Panigada M, Klompas M, Berra L
Curr Opin Crit Care 2022 Feb 1;28(1):74-82. doi: 10.1097/MCC.0000000000000908. PMID: 34932525Free PMC Article
Brown L, Leck AK, Gichangi M, Burton MJ, Denning DW
Lancet Infect Dis 2021 Mar;21(3):e49-e57. Epub 2020 Oct 22 doi: 10.1016/S1473-3099(20)30448-5. PMID: 33645500

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