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Disorder due cytochrome p450 CYP3A4

MedGen UID:
760103
•Concept ID:
CN181501
•
Sign or Symptom

Professional guidelines

PubMed

Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO).
Stemler J, Mellinghoff SC, Khodamoradi Y, Sprute R, Classen AY, Zapke SE, Hoenigl M, Krause R, Schmidt-Hieber M, Heinz WJ, Klein M, Koehler P, Liss B, Koldehoff M, Buhl C, Penack O, Maschmeyer G, Schalk E, Lass-Flörl C, Karthaus M, Ruhnke M, Cornely OA, Teschner D
J Antimicrob Chemother 2023 Aug 2;78(8):1813-1826. doi: 10.1093/jac/dkad143. PMID: 37311136Free PMC Article
Antifungal prophylaxis in adult patients with acute myeloid leukaemia treated with novel targeted therapies: a systematic review and expert consensus recommendation from the European Hematology Association.
Stemler J, de Jonge N, Skoetz N, Sinkó J, Brüggemann RJ, Busca A, Ben-Ami R, Ráčil Z, Piechotta V, Lewis R, Cornely OA
Lancet Haematol 2022 May;9(5):e361-e373. doi: 10.1016/S2352-3026(22)00073-4. PMID: 35483397
Buprenorphine: clinical pharmacokinetics in the treatment of opioid dependence.
Elkader A, Sproule B
Clin Pharmacokinet 2005;44(7):661-80. doi: 10.2165/00003088-200544070-00001. PMID: 15966752

Recent clinical studies

Etiology

Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO).
Stemler J, Mellinghoff SC, Khodamoradi Y, Sprute R, Classen AY, Zapke SE, Hoenigl M, Krause R, Schmidt-Hieber M, Heinz WJ, Klein M, Koehler P, Liss B, Koldehoff M, Buhl C, Penack O, Maschmeyer G, Schalk E, Lass-Flörl C, Karthaus M, Ruhnke M, Cornely OA, Teschner D
J Antimicrob Chemother 2023 Aug 2;78(8):1813-1826. doi: 10.1093/jac/dkad143. PMID: 37311136Free PMC Article
Importance of genetic polymorphisms in liver transplantation outcomes.
Kelava T, Turcic P, Markotic A, Ostojic A, Sisl D, Mrzljak A
World J Gastroenterol 2020 Mar 28;26(12):1273-1285. doi: 10.3748/wjg.v26.i12.1273. PMID: 32256016Free PMC Article
Trends in Tramadol: Pharmacology, Metabolism, and Misuse.
Miotto K, Cho AK, Khalil MA, Blanco K, Sasaki JD, Rawson R
Anesth Analg 2017 Jan;124(1):44-51. doi: 10.1213/ANE.0000000000001683. PMID: 27861439
Statin-related myotoxicity.
Fernandes V, Santos MJ, Pérez A
Endocrinol Nutr 2016 May;63(5):239-49. Epub 2016 Mar 19 doi: 10.1016/j.endonu.2016.01.001. PMID: 27005745
Green tea extract and the risk of drug-induced liver injury.
Teschke R, Zhang L, Melzer L, Schulze J, Eickhoff A
Expert Opin Drug Metab Toxicol 2014 Dec;10(12):1663-76. Epub 2014 Oct 15 doi: 10.1517/17425255.2014.971011. PMID: 25316200

Diagnosis

The Pharmacokinetics of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone.
Heinig R, Eissing T
Clin Pharmacokinet 2023 Dec;62(12):1673-1693. Epub 2023 Oct 24 doi: 10.1007/s40262-023-01312-9. PMID: 37875671Free PMC Article
First-in-human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC-2394, in healthy volunteers.
Tang F, Kunder R, Chu T, Hains A, Nguyen A, McBride JM, Zhong Y, Santagostino S, Wilson M, Trenchak A, Chen L, Ly J, Moein A, Lewin-Koh N, Raghavan V, Osaghae U, Wynne C, Owen R, Place D
Clin Transl Sci 2023 Sep;16(9):1653-1666. Epub 2023 Jul 23 doi: 10.1111/cts.13576. PMID: 37350225Free PMC Article
Calcium-channel blockers: Clinical outcome associations with reported pharmacogenetics variants in 32 000 patients.
Türkmen D, Masoli JAH, Delgado J, Kuo CL, Bowden J, Melzer D, Pilling LC
Br J Clin Pharmacol 2023 Feb;89(2):853-864. Epub 2022 Oct 6 doi: 10.1111/bcp.15541. PMID: 36134646Free PMC Article
Statin-related myotoxicity.
Fernandes V, Santos MJ, Pérez A
Endocrinol Nutr 2016 May;63(5):239-49. Epub 2016 Mar 19 doi: 10.1016/j.endonu.2016.01.001. PMID: 27005745
Colchicine-clarithromycin-induced rhabdomyolysis in Familial Mediterranean Fever patients under treatment for Helicobacter pylori.
Cohen O, Locketz G, Hershko AY, Gorshtein A, Levy Y
Rheumatol Int 2015 Nov;35(11):1937-41. Epub 2015 Jul 26 doi: 10.1007/s00296-015-3325-y. PMID: 26210999

Therapy

Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO).
Stemler J, Mellinghoff SC, Khodamoradi Y, Sprute R, Classen AY, Zapke SE, Hoenigl M, Krause R, Schmidt-Hieber M, Heinz WJ, Klein M, Koehler P, Liss B, Koldehoff M, Buhl C, Penack O, Maschmeyer G, Schalk E, Lass-Flörl C, Karthaus M, Ruhnke M, Cornely OA, Teschner D
J Antimicrob Chemother 2023 Aug 2;78(8):1813-1826. doi: 10.1093/jac/dkad143. PMID: 37311136Free PMC Article
Trends in Tramadol: Pharmacology, Metabolism, and Misuse.
Miotto K, Cho AK, Khalil MA, Blanco K, Sasaki JD, Rawson R
Anesth Analg 2017 Jan;124(1):44-51. doi: 10.1213/ANE.0000000000001683. PMID: 27861439
Statin-related myotoxicity.
Fernandes V, Santos MJ, Pérez A
Endocrinol Nutr 2016 May;63(5):239-49. Epub 2016 Mar 19 doi: 10.1016/j.endonu.2016.01.001. PMID: 27005745
The pharmacogenetics of antimalaria artemisinin combination therapy.
Piedade R, Gil JP
Expert Opin Drug Metab Toxicol 2011 Oct;7(10):1185-200. Epub 2011 Sep 8 doi: 10.1517/17425255.2011.608660. PMID: 21899476
The pharmacogenetics of calcineurin inhibitor-related nephrotoxicity.
Hesselink DA, Bouamar R, van Gelder T
Ther Drug Monit 2010 Aug;32(4):387-93. doi: 10.1097/FTD.0b013e3181e44244. PMID: 20571464

Prognosis

Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC.
Zhou X, An J, Kurilov R, Brors B, Hu K, Peccerella T, Roessler S, Pfütze K, Schulz A, Wolf S, Hohmann N, Theile D, Sauter M, Burhenne J, Ei S, Heger U, Strobel O, Barry ST, Springfeld C, Tjaden C, Bergmann F, Büchler M, Hackert T, Fortunato F, Neoptolemos JP, Bailey P
Nat Cancer 2023 Sep;4(9):1362-1381. Epub 2023 Sep 7 doi: 10.1038/s43018-023-00628-6. PMID: 37679568Free PMC Article
A systematic review of the drug-drug interaction between statins and colchicine: Patient characteristics, etiologies, and clinical management strategies.
Schwier NC, Cornelio CK, Boylan PM
Pharmacotherapy 2022 Apr;42(4):320-333. Epub 2022 Feb 25 doi: 10.1002/phar.2674. PMID: 35175631
Importance of genetic polymorphisms in liver transplantation outcomes.
Kelava T, Turcic P, Markotic A, Ostojic A, Sisl D, Mrzljak A
World J Gastroenterol 2020 Mar 28;26(12):1273-1285. doi: 10.3748/wjg.v26.i12.1273. PMID: 32256016Free PMC Article
Statin-related myotoxicity.
Fernandes V, Santos MJ, Pérez A
Endocrinol Nutr 2016 May;63(5):239-49. Epub 2016 Mar 19 doi: 10.1016/j.endonu.2016.01.001. PMID: 27005745
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.
Zanger UM, Schwab M
Pharmacol Ther 2013 Apr;138(1):103-41. Epub 2013 Jan 16 doi: 10.1016/j.pharmthera.2012.12.007. PMID: 23333322

Clinical prediction guides

Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC.
Zhou X, An J, Kurilov R, Brors B, Hu K, Peccerella T, Roessler S, Pfütze K, Schulz A, Wolf S, Hohmann N, Theile D, Sauter M, Burhenne J, Ei S, Heger U, Strobel O, Barry ST, Springfeld C, Tjaden C, Bergmann F, Büchler M, Hackert T, Fortunato F, Neoptolemos JP, Bailey P
Nat Cancer 2023 Sep;4(9):1362-1381. Epub 2023 Sep 7 doi: 10.1038/s43018-023-00628-6. PMID: 37679568Free PMC Article
How a concentration-effect analysis of data from the eliglustat thorough electrocardiographic study was used to support dosing recommendations.
Ruskin JN, Ortemann-Renon C, Msihid J, Ross L, Puga AC, Peterschmitt MJ, Cox GF, Maison-Blanche P
Mol Genet Metab 2020 Sep-Oct;131(1-2):211-218. Epub 2020 Sep 16 doi: 10.1016/j.ymgme.2020.09.003. PMID: 33012655
Importance of genetic polymorphisms in liver transplantation outcomes.
Kelava T, Turcic P, Markotic A, Ostojic A, Sisl D, Mrzljak A
World J Gastroenterol 2020 Mar 28;26(12):1273-1285. doi: 10.3748/wjg.v26.i12.1273. PMID: 32256016Free PMC Article
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.
Zanger UM, Schwab M
Pharmacol Ther 2013 Apr;138(1):103-41. Epub 2013 Jan 16 doi: 10.1016/j.pharmthera.2012.12.007. PMID: 23333322
The pharmacogenetics of calcineurin inhibitor-related nephrotoxicity.
Hesselink DA, Bouamar R, van Gelder T
Ther Drug Monit 2010 Aug;32(4):387-93. doi: 10.1097/FTD.0b013e3181e44244. PMID: 20571464

Recent systematic reviews

A systematic review of the drug-drug interaction between Statins and Quinolones.
Zhou J, Yu L, Xu H
BMC Pharmacol Toxicol 2024 Jul 10;25(1):39. doi: 10.1186/s40360-024-00760-8. PMID: 38987799Free PMC Article
Influence of genetic variants on the pharmacokinetics and pharmacodynamics of sirolimus: a systematic review.
Wm Te Loo DM, Harbers V, Vermeltfoort L, Coenen MJ
Pharmacogenomics 2023 Jul;24(11):629-639. Epub 2023 Aug 8 doi: 10.2217/pgs-2022-0147. PMID: 37551646
Antifungal prophylaxis in adult patients with acute myeloid leukaemia treated with novel targeted therapies: a systematic review and expert consensus recommendation from the European Hematology Association.
Stemler J, de Jonge N, Skoetz N, Sinkó J, Brüggemann RJ, Busca A, Ben-Ami R, Ráčil Z, Piechotta V, Lewis R, Cornely OA
Lancet Haematol 2022 May;9(5):e361-e373. doi: 10.1016/S2352-3026(22)00073-4. PMID: 35483397
A systematic review of the drug-drug interaction between statins and colchicine: Patient characteristics, etiologies, and clinical management strategies.
Schwier NC, Cornelio CK, Boylan PM
Pharmacotherapy 2022 Apr;42(4):320-333. Epub 2022 Feb 25 doi: 10.1002/phar.2674. PMID: 35175631
Influencing CYP enzymes to boost psychiatric treatment: a review on clinical evidence.
van Hasselt FM, Coehorst Y, Wilffert B, Loonen AJ
Pharmacopsychiatry 2013 Mar;46(2):43-6. Epub 2012 Oct 4 doi: 10.1055/s-0032-1323752. PMID: 23037948

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