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LEUKEMIA/LYMPHOMA, B-CELL, 2

MedGen UID:
854626
Concept ID:
C3887918
Neoplastic Process
Modes of inheritance:
Somatic mutation
MedGen UID:
107465
Concept ID:
C0544886
Cell or Molecular Dysfunction
Sources: HPO, OMIM
Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though they will be transmitted during any mitosis within the individual. Somatic mutations may contribute to a broad variety of pathologies including cancer.
Somatic mutation (HPO, OMIM)
 
OMIM®: 151430

Clinical features

B-cell lymphoma
MedGen UID:
86953
Concept ID:
C0079731
Neoplastic Process
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
B-cell lymphoma
MedGen UID:
86953
Concept ID:
C0079731
Neoplastic Process
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.

Recent clinical studies

Etiology

Konoplev S, Lu X, Konopleva M, Jain N, Ouyang J, Goswami M, Roberts KG, Valentine M, Mullighan CG, Bueso-Ramos C, Zweidler-McKay PA, Jorgensen JL, Wang SA
Am J Clin Pathol 2017 Apr 1;147(4):357-363. doi: 10.1093/ajcp/aqx005. PMID: 28340183
Tsurusawa M, Mori T, Kikuchi A, Mitsui T, Sunami S, Kobayashi R, Takimoto T, Saito A, Watanabe T, Fujimoto J, Nakazawa A, Ohshima K, Horibe K; lymphoma committee of Japanese Pediatric Leukemia/Lymphoma Study Group.
Pediatr Blood Cancer 2014 Jul;61(7):1215-21. Epub 2014 Feb 13 doi: 10.1002/pbc.24975. PMID: 24523211
Rouhigharabaei L, Ferreiro JF, Put N, Michaux L, Tousseyn T, Lefebvre C, Gardiner A, De Kelver W, Demuynck H, Verschuere J, Théate I, Vicente C, Vandenberghe P, Cools J, Wlodarska I
Genes Chromosomes Cancer 2013 Oct;52(10):928-44. Epub 2013 Jul 19 doi: 10.1002/gcc.22088. PMID: 23873701
Kedar R, Sabag O, Licthenstein M, Lorberboum-Galski H
Cancer 2012 Dec 15;118(24):6089-104. Epub 2012 Jun 12 doi: 10.1002/cncr.27654. PMID: 22692727
Chen W, Karandikar NJ, McKenna RW, Kroft SH
Am J Clin Pathol 2007 Jan;127(1):39-46. doi: 10.1309/7R6MU7R9YWJBY5V4. PMID: 17145625

Diagnosis

Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M
J Clin Exp Hematop 2017 Jul 5;57(1):15-20. Epub 2017 Apr 18 doi: 10.3960/jslrt.17003. PMID: 28420814
Waibel M, Gregory G, Shortt J, Johnstone RW
Curr Opin Hematol 2014 Jul;21(4):297-308. doi: 10.1097/MOH.0000000000000045. PMID: 24811162
Niino D, Ohsaki K, Arakawa F, Watanabe J, Kimura Y, Kiyasu J, Takeuchi M, Miyoshi H, Yoshida M, Sugita Y, Ohshima K, Okamura T
Pathol Int 2011 Jun;61(6):363-8. Epub 2011 Mar 13 doi: 10.1111/j.1440-1827.2011.02662.x. PMID: 21615612
Nasr MR, Rosenthal N, Syrbu S
Am J Clin Pathol 2010 Jan;133(1):41-8. doi: 10.1309/AJCPYP00JNUFWCCY. PMID: 20023257
Zheng ZJ, Xu RL
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2003 Aug;11(4):398-404. PMID: 12962571

Therapy

Davids MS
Blood 2017 Aug 31;130(9):1081-1088. Epub 2017 Jul 19 doi: 10.1182/blood-2017-04-737338. PMID: 28724540
Tsurusawa M, Mori T, Kikuchi A, Mitsui T, Sunami S, Kobayashi R, Takimoto T, Saito A, Watanabe T, Fujimoto J, Nakazawa A, Ohshima K, Horibe K; lymphoma committee of Japanese Pediatric Leukemia/Lymphoma Study Group.
Pediatr Blood Cancer 2014 Jul;61(7):1215-21. Epub 2014 Feb 13 doi: 10.1002/pbc.24975. PMID: 24523211
Kedar R, Sabag O, Licthenstein M, Lorberboum-Galski H
Cancer 2012 Dec 15;118(24):6089-104. Epub 2012 Jun 12 doi: 10.1002/cncr.27654. PMID: 22692727
Niino D, Ohsaki K, Arakawa F, Watanabe J, Kimura Y, Kiyasu J, Takeuchi M, Miyoshi H, Yoshida M, Sugita Y, Ohshima K, Okamura T
Pathol Int 2011 Jun;61(6):363-8. Epub 2011 Mar 13 doi: 10.1111/j.1440-1827.2011.02662.x. PMID: 21615612
Moleti ML, Testi AM, Giona F, Malandruccolo L, Pescarmona E, Martino P, Paoloni F, Barberi W, Palumbo G, Mandelli F, Foa R
Leuk Lymphoma 2007 Mar;48(3):551-9. doi: 10.1080/10428190601078944. PMID: 17454598

Prognosis

Tsurusawa M, Mori T, Kikuchi A, Mitsui T, Sunami S, Kobayashi R, Takimoto T, Saito A, Watanabe T, Fujimoto J, Nakazawa A, Ohshima K, Horibe K; lymphoma committee of Japanese Pediatric Leukemia/Lymphoma Study Group.
Pediatr Blood Cancer 2014 Jul;61(7):1215-21. Epub 2014 Feb 13 doi: 10.1002/pbc.24975. PMID: 24523211
Kishimoto W, Shirase T, Chihara D, Maeda T, Arimoto-Miyamoto K, Takeoka T, Tsuji M, Ohno T, Kita K
J Clin Exp Hematop 2012;52(2):113-9. PMID: 23037627
Nasr MR, Rosenthal N, Syrbu S
Am J Clin Pathol 2010 Jan;133(1):41-8. doi: 10.1309/AJCPYP00JNUFWCCY. PMID: 20023257
Moleti ML, Testi AM, Giona F, Malandruccolo L, Pescarmona E, Martino P, Paoloni F, Barberi W, Palumbo G, Mandelli F, Foa R
Leuk Lymphoma 2007 Mar;48(3):551-9. doi: 10.1080/10428190601078944. PMID: 17454598
Chen W, Karandikar NJ, McKenna RW, Kroft SH
Am J Clin Pathol 2007 Jan;127(1):39-46. doi: 10.1309/7R6MU7R9YWJBY5V4. PMID: 17145625

Clinical prediction guides

Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M
J Clin Exp Hematop 2017 Jul 5;57(1):15-20. Epub 2017 Apr 18 doi: 10.3960/jslrt.17003. PMID: 28420814
Deng L, Xu-Monette ZY, Loghavi S, Manyam GC, Xia Y, Visco C, Huh J, Zhang L, Zhai Q, Wang Y, Qiu L, Dybkær K, Chiu A, Perry AM, Zhang S, Tzankov A, Rao H, Abramson J, Sohani AR, Xu M, Hsi ED, Zhu J, Ponzoni M, Wang S, Li L, Zhang M, Ferreri AJ, Parsons BM, Li Y, Piris MA, Medeiros LJ, Young KH
Leukemia 2016 Feb;30(2):361-72. Epub 2013 Aug 26 doi: 10.1038/leu.2015.237. PMID: 26308769
Rouhigharabaei L, Ferreiro JF, Put N, Michaux L, Tousseyn T, Lefebvre C, Gardiner A, De Kelver W, Demuynck H, Verschuere J, Théate I, Vicente C, Vandenberghe P, Cools J, Wlodarska I
Genes Chromosomes Cancer 2013 Oct;52(10):928-44. Epub 2013 Jul 19 doi: 10.1002/gcc.22088. PMID: 23873701
Hedlund M, Nagaeva O, Kargl D, Baranov V, Mincheva-Nilsson L
PLoS One 2011 Feb 25;6(2):e16899. doi: 10.1371/journal.pone.0016899. PMID: 21364924Free PMC Article
Nasr MR, Rosenthal N, Syrbu S
Am J Clin Pathol 2010 Jan;133(1):41-8. doi: 10.1309/AJCPYP00JNUFWCCY. PMID: 20023257

Recent systematic reviews

Montenegro-Garreaud X, Miranda RN, Reynolds A, Tang G, Wang SA, Yabe M, Wang W, Fang L, Bueso-Ramos CE, Lin P, Medeiros LJ, Lu X
Hum Pathol 2017 Jul;65:147-156. Epub 2017 May 24 doi: 10.1016/j.humpath.2017.05.008. PMID: 28551329
Perry AM, Diebold J, Nathwani BN, MacLennan KA, Müller-Hermelink HK, Bast M, Boilesen E, Armitage JO, Weisenburger DD
Haematologica 2016 Oct;101(10):1244-1250. Epub 2016 Jun 27 doi: 10.3324/haematol.2016.148809. PMID: 27354024Free PMC Article
Skibola CF, Slager SL, Berndt SI, Lightfoot T, Sampson JN, Morton LM, Weisenburger DD
J Natl Cancer Inst Monogr 2014 Aug;2014(48):125-9. doi: 10.1093/jncimonographs/lgu009. PMID: 25174033Free PMC Article
Tajima K
Int J Cancer 1990 Feb 15;45(2):237-43. PMID: 2303290

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