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Obsessive compulsive disorder(OCD)

MedGen UID:
14445
Concept ID:
C0028768
Mental or Behavioral Dysfunction
Synonyms: Anankastic Personalities; Anankastic Personality; Disorder, Obsessive-Compulsive; Disorders, Obsessive-Compulsive; Neuroses, Obsessive-Compulsive; Neurosis, Obsessive Compulsive; Neurosis, Obsessive-Compulsive; Obsessive Compulsive Disorder; Obsessive-Compulsive Disorder; Obsessive-Compulsive Disorders; Obsessive-Compulsive Neuroses; Obsessive-Compulsive Neurosis; Personalities, Anankastic; Personality, Anankastic
SNOMED CT: Obsessive compulsive disorder (191736004); Obsessive compulsive neurosis (191736004); Anancastic neurosis (191736004); Anankastic neurosis (191736004); OCD - Obsessive-compulsive disorder (191736004); Obsessive-compulsive disorder (191736004)
 
OMIM®: 164230
HPO: HP:0000722

Definition

A disorder characterized by the presence of persistent and recurrent irrational thoughts (obsessions), resulting in marked anxiety and repetitive excessive behaviors (compulsions) as a way to try to decrease that anxiety. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVObsessive compulsive disorder

Recent clinical studies

Etiology

Dohrmann AL, Stengler K, Jahn I, Olbrich S
Clin Neurophysiol 2017 Oct;128(10):1906-1914. Epub 2017 Jul 31 doi: 10.1016/j.clinph.2017.07.406. PMID: 28826021
Shahar N, Teodorescu AR, Anholt GE, Karmon-Presser A, Meiran N
Psychiatry Res 2017 Jul;253:197-204. Epub 2017 Mar 27 doi: 10.1016/j.psychres.2017.03.048. PMID: 28390295
Gomes JB, Cordioli AV, Heldt E
Psychiatry Res 2017 Jul;253:107-109. Epub 2017 Mar 23 doi: 10.1016/j.psychres.2017.03.043. PMID: 28364587
Lei H, Zhong M, Fan J, Zhang X, Cai L, Zhu X
Psychiatry Res 2017 Jun;252:180-184. Epub 2017 Mar 2 doi: 10.1016/j.psychres.2017.02.063. PMID: 28282536
Rus OG, Reess TJ, Wagner G, Zaudig M, Zimmer C, Koch K
Psychol Med 2017 Apr;47(6):1053-1061. Epub 2016 Dec 12 doi: 10.1017/S0033291716003202. PMID: 27938423

Diagnosis

Dohrmann AL, Stengler K, Jahn I, Olbrich S
Clin Neurophysiol 2017 Oct;128(10):1906-1914. Epub 2017 Jul 31 doi: 10.1016/j.clinph.2017.07.406. PMID: 28826021
Shahar N, Teodorescu AR, Anholt GE, Karmon-Presser A, Meiran N
Psychiatry Res 2017 Jul;253:197-204. Epub 2017 Mar 27 doi: 10.1016/j.psychres.2017.03.048. PMID: 28390295
Lei H, Zhong M, Fan J, Zhang X, Cai L, Zhu X
Psychiatry Res 2017 Jun;252:180-184. Epub 2017 Mar 2 doi: 10.1016/j.psychres.2017.02.063. PMID: 28282536
Cludius B, Schmidt AF, Moritz S, Banse R, Jelinek L
J Behav Ther Exp Psychiatry 2017 Jun;55:106-112. Epub 2017 Jan 6 doi: 10.1016/j.jbtep.2017.01.001. PMID: 28113062
Bernstein GA, Hadjiyanni T, Cullen KR, Robinson JW, Harris EC, Young AD, Fasching J, Walczak N, Lee S, Morellas V, Papanikolopoulos N
J Child Adolesc Psychopharmacol 2017 Mar;27(2):140-147. Epub 2016 Nov 10 doi: 10.1089/cap.2016.0067. PMID: 27830935

Therapy

Dohrmann AL, Stengler K, Jahn I, Olbrich S
Clin Neurophysiol 2017 Oct;128(10):1906-1914. Epub 2017 Jul 31 doi: 10.1016/j.clinph.2017.07.406. PMID: 28826021
Gomes JB, Cordioli AV, Heldt E
Psychiatry Res 2017 Jul;253:107-109. Epub 2017 Mar 23 doi: 10.1016/j.psychres.2017.03.043. PMID: 28364587
Voon V, Droux F, Morris L, Chabardes S, Bougerol T, David O, Krack P, Polosan M
Brain 2017 Feb;140(2):442-456. Epub 2016 Dec 31 doi: 10.1093/brain/aww309. PMID: 28040671Free PMC Article
de Leeuw AS, van Megen HJ, Kahn RS, Westenberg HG
Eur Psychiatry 2017 Feb;40:38-44. Epub 2016 Nov 10 doi: 10.1016/j.eurpsy.2016.06.011. PMID: 27837671
Bernstein GA, Hadjiyanni T, Cullen KR, Robinson JW, Harris EC, Young AD, Fasching J, Walczak N, Lee S, Morellas V, Papanikolopoulos N
J Child Adolesc Psychopharmacol 2017 Mar;27(2):140-147. Epub 2016 Nov 10 doi: 10.1089/cap.2016.0067. PMID: 27830935

Prognosis

Dohrmann AL, Stengler K, Jahn I, Olbrich S
Clin Neurophysiol 2017 Oct;128(10):1906-1914. Epub 2017 Jul 31 doi: 10.1016/j.clinph.2017.07.406. PMID: 28826021
Gomes JB, Cordioli AV, Heldt E
Psychiatry Res 2017 Jul;253:107-109. Epub 2017 Mar 23 doi: 10.1016/j.psychres.2017.03.043. PMID: 28364587
Stewart SE, Hu YP, Leung A, Chan E, Hezel DM, Lin SY, Belschner L, Walsh C, Geller DA, Pauls DL
J Am Acad Child Adolesc Psychiatry 2017 Mar;56(3):241-249.e3. Epub 2016 Dec 27 doi: 10.1016/j.jaac.2016.12.012. PMID: 28219490Free PMC Article
Hauser TU, Iannaccone R, Dolan RJ, Ball J, Hättenschwiler J, Drechsler R, Rufer M, Brandeis D, Walitza S, Brem S
Psychol Med 2017 May;47(7):1246-1258. Epub 2017 Jan 9 doi: 10.1017/S0033291716003305. PMID: 28065182
Hellriegel J, Barber C, Wikramanayake M, Fineberg NA, Mandy W
CNS Spectr 2017 Feb;22(1):41-50. Epub 2016 Nov 11 doi: 10.1017/S1092852916000511. PMID: 27834163

Clinical prediction guides

Dohrmann AL, Stengler K, Jahn I, Olbrich S
Clin Neurophysiol 2017 Oct;128(10):1906-1914. Epub 2017 Jul 31 doi: 10.1016/j.clinph.2017.07.406. PMID: 28826021
Tezcan D, Tumkaya S, Bora E
Psychiatry Res 2017 Jun;252:231-233. Epub 2017 Mar 6 doi: 10.1016/j.psychres.2017.03.001. PMID: 28285250
Stewart SE, Hu YP, Leung A, Chan E, Hezel DM, Lin SY, Belschner L, Walsh C, Geller DA, Pauls DL
J Am Acad Child Adolesc Psychiatry 2017 Mar;56(3):241-249.e3. Epub 2016 Dec 27 doi: 10.1016/j.jaac.2016.12.012. PMID: 28219490Free PMC Article
Cludius B, Schmidt AF, Moritz S, Banse R, Jelinek L
J Behav Ther Exp Psychiatry 2017 Jun;55:106-112. Epub 2017 Jan 6 doi: 10.1016/j.jbtep.2017.01.001. PMID: 28113062
Hauser TU, Iannaccone R, Dolan RJ, Ball J, Hättenschwiler J, Drechsler R, Rufer M, Brandeis D, Walitza S, Brem S
Psychol Med 2017 May;47(7):1246-1258. Epub 2017 Jan 9 doi: 10.1017/S0033291716003305. PMID: 28065182

Recent systematic reviews

Zhou DD, Wang W, Wang GM, Li DQ, Kuang L
J Affect Disord 2017 Jun;215:187-196. Epub 2017 Mar 18 doi: 10.1016/j.jad.2017.03.033. PMID: 28340445
De Putter LM, Van Yper L, Koster EH
Clin Psychol Rev 2017 Mar;52:137-147. Epub 2017 Jan 16 doi: 10.1016/j.cpr.2017.01.001. PMID: 28119197
Varigonda AL, Jakubovski E, Bloch MH
J Am Acad Child Adolesc Psychiatry 2016 Oct;55(10):851-859.e2. Epub 2016 Aug 4 doi: 10.1016/j.jaac.2016.07.768. PMID: 27663940
Skapinakis P, Caldwell DM, Hollingworth W, Bryden P, Fineberg NA, Salkovskis P, Welton NJ, Baxter H, Kessler D, Churchill R, Lewis G
Lancet Psychiatry 2016 Aug;3(8):730-739. Epub 2016 Jun 16 doi: 10.1016/S2215-0366(16)30069-4. PMID: 27318812Free PMC Article
Del Casale A, Rapinesi C, Kotzalidis GD, De Rossi P, Curto M, Janiri D, Criscuolo S, Alessi MC, Ferri VR, De Giorgi R, Sani G, Ferracuti S, Girardi P, Brugnoli R
World J Biol Psychiatry 2016 Aug;17(5):378-93. Epub 2015 Dec 7 doi: 10.3109/15622975.2015.1102323. PMID: 26642972

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