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Adenomyosis

MedGen UID:
90971
Concept ID:
C0341858
Disease or Syndrome
Synonyms: Adenomyoses
SNOMED CT: Endometriosis of uterus (76376003); Internal endometriosis (76376003); Adenomyosis (76376003); Adenomyosis uteri (76376003); Endometriosis interna (198247003); Endometriosis of myometrium (237115002)
 
OMIM®: 600458

Definition

Adenomyosis is characterized by the presence of endometrial glands and stroma within the myometrium. Abnormal uterine bleeding and dysmenorrhea are the most characteristic symptoms, occurring in approximately 65% of cases (Arnold et al., 1995). [from OMIM]

Clinical features

Dysmenorrhea
MedGen UID:
4429
Concept ID:
C0013390
Pathologic Function
Pain during menstruation that interferes with daily activities.
Abnormal bleeding
MedGen UID:
264316
Concept ID:
C1458140
Pathologic Function
Normally, if you get hurt, your body forms a blood clot to stop the bleeding. For blood to clot, your body needs cells called platelets and proteins known as clotting factors. If you have a bleeding disorder, you either do not have enough platelets or clotting factors or they don't work the way they should. . Bleeding disorders can be the result of other diseases, such as severe liver disease. They can also be inherited. Hemophilia is an inherited bleeding disorder. Bleeding disorders can also be a side effect of medicines.
Abnormality of the genitourinary system
MedGen UID:
892370
Concept ID:
C4020895
Anatomical Abnormality
The presence of any abnormality of the genitourinary system.
Dysmenorrhea
MedGen UID:
4429
Concept ID:
C0013390
Pathologic Function
Pain during menstruation that interferes with daily activities.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenomyosis

Recent clinical studies

Etiology

Vinci V, Saldari M, Sergi ME, Bernardo S, Rizzo G, Porpora MG, Catalano C, Manganaro L
Radiol Med 2017 May;122(5):361-368. Epub 2017 Feb 15 doi: 10.1007/s11547-017-0729-7. PMID: 28197875
Streuli I, Santulli P, Chouzenoux S, Chapron C, Batteux F
Reprod Sci 2017 May;24(5):773-782. Epub 2016 Sep 27 doi: 10.1177/1933719116669054. PMID: 27678100
Takeuchi A, Koga K, Miyashita M, Makabe T, Sue F, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y
Eur J Obstet Gynecol Reprod Biol 2016 Dec;207:157-161. Epub 2016 Nov 8 doi: 10.1016/j.ejogrb.2016.10.053. PMID: 27865118
Yamanaka A, Kimura F, Yoshida T, Kita N, Takahashi K, Kushima R, Murakmai T
Eur J Obstet Gynecol Reprod Biol 2016 Sep;204:99-103. Epub 2016 Aug 3 doi: 10.1016/j.ejogrb.2016.07.499. PMID: 27543913
Busca A, Parra-Herran C
Pathol Res Pract 2016 Sep;212(9):778-82. Epub 2016 Jun 23 doi: 10.1016/j.prp.2016.06.007. PMID: 27461823

Diagnosis

Vinci V, Saldari M, Sergi ME, Bernardo S, Rizzo G, Porpora MG, Catalano C, Manganaro L
Radiol Med 2017 May;122(5):361-368. Epub 2017 Feb 15 doi: 10.1007/s11547-017-0729-7. PMID: 28197875
Li Y, Qi H, Ma W, Wu C, Li X, Zhao D, Ye W, Xiang M
J Minim Invasive Gynecol 2017 Mar - Apr;24(3):349-352. Epub 2016 Oct 1 doi: 10.1016/j.jmig.2016.09.014. PMID: 27702702
Streuli I, Santulli P, Chouzenoux S, Chapron C, Batteux F
Reprod Sci 2017 May;24(5):773-782. Epub 2016 Sep 27 doi: 10.1177/1933719116669054. PMID: 27678100
Orazov MR, Nosenko EN, Radzinsky VE, Khamoshina MB, Lebedeva MG, Sounov MA
Gynecol Endocrinol 2016 Oct;32(sup2):7-10. doi: 10.1080/09513590.2016.1232902. PMID: 27759451
Puente JM, Fabris A, Patel J, Patel A, Cerrillo M, Requena A, Garcia-Velasco JA
Reprod Biol Endocrinol 2016 Sep 20;14(1):60. doi: 10.1186/s12958-016-0185-6. PMID: 27645154Free PMC Article

Therapy

Takeuchi A, Koga K, Miyashita M, Makabe T, Sue F, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y
Eur J Obstet Gynecol Reprod Biol 2016 Dec;207:157-161. Epub 2016 Nov 8 doi: 10.1016/j.ejogrb.2016.10.053. PMID: 27865118
Busca A, Parra-Herran C
Pathol Res Pract 2016 Sep;212(9):778-82. Epub 2016 Jun 23 doi: 10.1016/j.prp.2016.06.007. PMID: 27461823
Jiang JF, Sun AJ, Xue W, Deng Y, Wang YF
Eur J Obstet Gynecol Reprod Biol 2016 Apr;199:32-7. Epub 2016 Feb 8 doi: 10.1016/j.ejogrb.2016.01.033. PMID: 26896594
Mansouri R, Santos XM, Bercaw-Pratt JL, Dietrich JE
J Pediatr Adolesc Gynecol 2015 Dec;28(6):437-40. Epub 2014 Dec 29 doi: 10.1016/j.jpag.2014.12.009. PMID: 26233288
Chen J, Chen W, Zhang L, Li K, Peng S, He M, Hu L
Ultrason Sonochem 2015 Nov;27:671-6. Epub 2015 May 27 doi: 10.1016/j.ultsonch.2015.05.031. PMID: 26093678

Prognosis

Jiang C, Liu C, Guo J, Chen L, Luo N, Qu X, Yang W, Ren Q, Cheng Z
Medicine (Baltimore) 2017 May;96(19):e6880. doi: 10.1097/MD.0000000000006880. PMID: 28489790Free PMC Article
Zhou J, He L, Liu P, Duan H, Zhang H, Li W, Gong S, Su G, Chen C
PLoS One 2016;11(11):e0165610. Epub 2016 Nov 2 doi: 10.1371/journal.pone.0165610. PMID: 27806072Free PMC Article
Busca A, Parra-Herran C
Pathol Res Pract 2016 Sep;212(9):778-82. Epub 2016 Jun 23 doi: 10.1016/j.prp.2016.06.007. PMID: 27461823
Manta L, Suciu N, Constantin A, Toader O, Popa F
J Med Life 2016 Apr-Jun;9(2):180-2. PMID: 27453751Free PMC Article
Dakhly DM, Abdel Moety GA, Saber W, Gad Allah SH, Hashem AT, Abdel Salam LO
J Minim Invasive Gynecol 2016 Mar-Apr;23(3):364-71. Epub 2015 Nov 12 doi: 10.1016/j.jmig.2015.11.004. PMID: 26581187

Clinical prediction guides

Jiang C, Liu C, Guo J, Chen L, Luo N, Qu X, Yang W, Ren Q, Cheng Z
Medicine (Baltimore) 2017 May;96(19):e6880. doi: 10.1097/MD.0000000000006880. PMID: 28489790Free PMC Article
Chen L, Li C, Guo J, Luo N, Qu X, Kang L, Liu M, Cheng Z
PLoS One 2017;12(4):e0175511. Epub 2017 Apr 13 doi: 10.1371/journal.pone.0175511. PMID: 28406930Free PMC Article
Li Y, Qi H, Ma W, Wu C, Li X, Zhao D, Ye W, Xiang M
J Minim Invasive Gynecol 2017 Mar - Apr;24(3):349-352. Epub 2016 Oct 1 doi: 10.1016/j.jmig.2016.09.014. PMID: 27702702
Shimizu A, Tanaka H, Iwasaki S, Wakui Y, Ikeda H, Suzuki A
Diagn Pathol 2016 Aug 4;11(1):69. doi: 10.1186/s13000-016-0523-1. PMID: 27491369Free PMC Article
Busca A, Parra-Herran C
Pathol Res Pract 2016 Sep;212(9):778-82. Epub 2016 Jun 23 doi: 10.1016/j.prp.2016.06.007. PMID: 27461823

Recent systematic reviews

Ye H, He Y, Wang J, Song T, Lan Z, Zhao Y, Xi M
J Genet 2016 Sep;95(3):611-9. PMID: 27659332
Pontis A, D'Alterio MN, Pirarba S, de Angelis C, Tinelli R, Angioni S
Gynecol Endocrinol 2016 Sep;32(9):696-700. Epub 2016 Jul 5 doi: 10.1080/09513590.2016.1197200. PMID: 27379972
Benagiano G, Brosens I, Habiba M
Reprod Biomed Online 2015 Mar;30(3):220-32. Epub 2014 Nov 20 doi: 10.1016/j.rbmo.2014.11.005. PMID: 25599903
Vercellini P, Consonni D, Barbara G, Buggio L, Frattaruolo MP, Somigliana E
Reprod Biomed Online 2014 Jun;28(6):704-13. Epub 2014 Mar 4 doi: 10.1016/j.rbmo.2014.02.006. PMID: 24745831
Vercellini P, Consonni D, Dridi D, Bracco B, Frattaruolo MP, Somigliana E
Hum Reprod 2014 May;29(5):964-77. Epub 2014 Mar 12 doi: 10.1093/humrep/deu041. PMID: 24622619

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