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Alcohol dependence

MedGen UID:
1801
Concept ID:
C0001973
Mental or Behavioral Dysfunction
Synonyms: ALCOHOL DEPENDENCE, PROTECTION AGAINST; ALCOHOLISM
SNOMED CT: Alcohol dependence (66590003); Chronic alcoholism (66590003); Alcoholism (7200002); Persistent alcohol abuse (284591009); Chronic alcohol abuse (284591009); Alcohol dependence syndrome (66590003); Dipsomania (7200002); Alcohol problem drinking (7200002)
 
Genes (locations): ADH1B (4q23); ADH1C (4q23); GABRA2 (4p12); HTR2A (13q14.2); RCBTB1 (13q14.2); TAS2R16 (7q31.32)
OMIM®: 103780
HPO: HP:0030955

Definition

A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4) [from MeSH]

Clinical features

Abnormality of the nervous system
MedGen UID:
105425
Concept ID:
C0497552
Congenital Abnormality
An abnormality of the nervous system that is present at birth or detected in the neonatal period.

Term Hierarchy

Recent clinical studies

Etiology

Kong X, Deng H, Gong S, Alston T, Kong Y, Wang J
BMC Med Genet 2017 Oct 26;18(1):120. doi: 10.1186/s12881-017-0478-4. PMID: 29070014Free PMC Article
Grynberg D, de Timary P, Philippot P, D'Hondt F, Briane Y, Devynck F, Douilliez C, Billieux J, Heeren A, Maurage P
J Addict Dis 2016 Oct-Dec;35(4):238-243. Epub 2016 Jul 18 doi: 10.1080/10550887.2016.1207970. PMID: 27431454
Cousins G, Mongan D, Barry J, Smyth B, Rackard M, Long J
Alcohol Clin Exp Res 2016 Aug;40(8):1700-6. Epub 2016 Jun 24 doi: 10.1111/acer.13126. PMID: 27339769
Oo KZ, Aung YK, Jenkins MA, Win AK
Aust N Z J Psychiatry 2016 Sep;50(9):842-57. Epub 2016 Mar 15 doi: 10.1177/0004867416637920. PMID: 26979101
Narita S, Nagahori K, Nishizawa D, Yoshihara E, Kawai A, Ikeda K, Iwahashi K
Acta Neuropsychiatr 2016 Aug;28(4):214-20. Epub 2016 Jan 14 doi: 10.1017/neu.2015.70. PMID: 26763194

Diagnosis

Kong X, Deng H, Gong S, Alston T, Kong Y, Wang J
BMC Med Genet 2017 Oct 26;18(1):120. doi: 10.1186/s12881-017-0478-4. PMID: 29070014Free PMC Article
Goodyear K, Lee MR, Schwandt ML, Hodgkinson CA, Leggio L
World J Biol Psychiatry 2017 Mar;18(2):120-128. Epub 2016 Dec 1 doi: 10.1080/15622975.2016.1249952. PMID: 27905213Free PMC Article
Cousins G, Mongan D, Barry J, Smyth B, Rackard M, Long J
Alcohol Clin Exp Res 2016 Aug;40(8):1700-6. Epub 2016 Jun 24 doi: 10.1111/acer.13126. PMID: 27339769
Oo KZ, Aung YK, Jenkins MA, Win AK
Aust N Z J Psychiatry 2016 Sep;50(9):842-57. Epub 2016 Mar 15 doi: 10.1177/0004867416637920. PMID: 26979101
Witkiewitz K, Hallgren KA, O'Sickey AJ, Roos CR, Maisto SA
Drug Alcohol Depend 2016 Jan 1;158:86-93. Epub 2015 Nov 10 doi: 10.1016/j.drugalcdep.2015.11.001. PMID: 26613839Free PMC Article

Therapy

Petit G, Luminet O, Cordovil de Sousa Uva M, Monhonval P, Leclercq S, Spilliaert Q, Zammit F, Maurage P, de Timary P
Alcohol Clin Exp Res 2017 Feb;41(2):421-431. Epub 2017 Jan 6 doi: 10.1111/acer.13292. PMID: 28060415
Rolland B, Auffret M, Franchitto N
Expert Opin Drug Saf 2016 Jun;15(6):747-51. Epub 2016 Apr 1 doi: 10.1517/14740338.2016.1168397. PMID: 26987987
Witkiewitz K, Hallgren KA, O'Sickey AJ, Roos CR, Maisto SA
Drug Alcohol Depend 2016 Jan 1;158:86-93. Epub 2015 Nov 10 doi: 10.1016/j.drugalcdep.2015.11.001. PMID: 26613839Free PMC Article
D'Hondt F, de Timary P, Bruneau Y, Maurage P
Drug Alcohol Depend 2015 Nov 1;156:267-274. Epub 2015 Sep 26 doi: 10.1016/j.drugalcdep.2015.09.017. PMID: 26433563
Hallgren M, Romberg K, Bakshi AS, Andréasson S
Complement Ther Med 2014 Jun;22(3):441-5. Epub 2014 Mar 15 doi: 10.1016/j.ctim.2014.03.003. PMID: 24906582

Prognosis

Petit G, Luminet O, Cordovil de Sousa Uva M, Monhonval P, Leclercq S, Spilliaert Q, Zammit F, Maurage P, de Timary P
Alcohol Clin Exp Res 2017 Feb;41(2):421-431. Epub 2017 Jan 6 doi: 10.1111/acer.13292. PMID: 28060415
Goodyear K, Lee MR, Schwandt ML, Hodgkinson CA, Leggio L
World J Biol Psychiatry 2017 Mar;18(2):120-128. Epub 2016 Dec 1 doi: 10.1080/15622975.2016.1249952. PMID: 27905213Free PMC Article
Chartier KG, Thomas NS, Kendler KS
Psychol Med 2017 Jan;47(1):137-147. Epub 2016 Sep 29 doi: 10.1017/S0033291716002105. PMID: 27681653Free PMC Article
Cheng HG, Chandra M, Alcover KC, Anthony JC
Drug Alcohol Depend 2016 Nov 1;168:61-68. Epub 2016 Aug 21 doi: 10.1016/j.drugalcdep.2016.08.015. PMID: 27620346Free PMC Article
Grynberg D, de Timary P, Philippot P, D'Hondt F, Briane Y, Devynck F, Douilliez C, Billieux J, Heeren A, Maurage P
J Addict Dis 2016 Oct-Dec;35(4):238-243. Epub 2016 Jul 18 doi: 10.1080/10550887.2016.1207970. PMID: 27431454

Clinical prediction guides

Tu HP, Tung YC, Tsai WC, Lin GT, Ko YC, Lee SS
Joint Bone Spine 2017 Mar;84(2):189-196. Epub 2016 May 26 doi: 10.1016/j.jbspin.2016.02.024. PMID: 27238189
Grynberg D, de Timary P, Philippot P, D'Hondt F, Briane Y, Devynck F, Douilliez C, Billieux J, Heeren A, Maurage P
J Addict Dis 2016 Oct-Dec;35(4):238-243. Epub 2016 Jul 18 doi: 10.1080/10550887.2016.1207970. PMID: 27431454
Cousins G, Mongan D, Barry J, Smyth B, Rackard M, Long J
Alcohol Clin Exp Res 2016 Aug;40(8):1700-6. Epub 2016 Jun 24 doi: 10.1111/acer.13126. PMID: 27339769
Khemiri L, Kuja-Halkola R, Larsson H, Jayaram-Lindström N
Psychol Med 2016 Apr;46(5):1091-102. Epub 2015 Dec 16 doi: 10.1017/S0033291715002652. PMID: 26671289
Clarke TK, Smith AH, Gelernter J, Kranzler HR, Farrer LA, Hall LS, Fernandez-Pujals AM, MacIntyre DJ, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, Thomson PA, Porteous DJ, Deary IJ, McIntosh AM
Addict Biol 2016 Mar;21(2):469-80. Epub 2015 Apr 10 doi: 10.1111/adb.12245. PMID: 25865819Free PMC Article

Recent systematic reviews

Kong X, Deng H, Gong S, Alston T, Kong Y, Wang J
BMC Med Genet 2017 Oct 26;18(1):120. doi: 10.1186/s12881-017-0478-4. PMID: 29070014Free PMC Article
Oo KZ, Aung YK, Jenkins MA, Win AK
Aust N Z J Psychiatry 2016 Sep;50(9):842-57. Epub 2016 Mar 15 doi: 10.1177/0004867416637920. PMID: 26979101
Zuo L, Tan Y, Zhang X, Wang X, Krystal J, Tabakoff B, Zhong C, Luo X
Alcohol Clin Exp Res 2015 Aug;39(8):1388-95. Epub 2015 Jul 14 doi: 10.1111/acer.12786. PMID: 26173551Free PMC Article
Zuo L, Lu L, Tan Y, Pan X, Cai Y, Wang X, Hong J, Zhong C, Wang F, Zhang XY, Vanderlinden LA, Tabakoff B, Luo X
Am J Addict 2014 Nov-Dec;23(6):526-39. doi: 10.1111/j.1521-0391.2014.12147.x. PMID: 25278008Free PMC Article
Levola J, Kaskela T, Holopainen A, Sabariego C, Tourunen J, Cieza A, Pitkänen T
Disabil Rehabil 2014;36(15):1227-39. Epub 2013 Sep 30 doi: 10.3109/09638288.2013.837104. PMID: 24079366

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