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Items: 10

1.

Tissue plasminogen activator preparation

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. [from MeSH]

MedGen UID:
10794
Concept ID:
C0032143
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
2.

Plasminogen

Plasminogen (810 aa, ~91 kDa) is encoded by the human PLG gene. This protein is involved in fibrinolysis, platelet activation and tissue remodeling. [from NCI]

MedGen UID:
10793
Concept ID:
C0032140
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
3.

Myocardial infarction

Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis. [from NCI]

MedGen UID:
10150
Concept ID:
C0027051
Disease or Syndrome
4.

Infarct

A localized pathological necrosis of tissue resulting from obstruction of the blood supply usually by a thrombus, an embolus, or vascular torsion. [from NCI]

MedGen UID:
9461
Concept ID:
C0021308
Pathologic Function
5.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
6.

Myocardial infarction

Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin. [from HPO]

MedGen UID:
504896
Concept ID:
CN001509
Finding
7.

Acute myocardial infarction

Necrosis of the myocardium, as a result of interruption of the blood supply to the area. It is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations. [from NCI]

MedGen UID:
57611
Concept ID:
C0155626
Disease or Syndrome
8.

Risk factor

An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, on the basis of epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. [from MeSH]

MedGen UID:
48477
Concept ID:
C0035648
Finding
9.

Multiple endocrine neoplasia

A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively. [from MeSH]

MedGen UID:
45036
Concept ID:
C0027662
Neoplastic Process
10.

Plasminogen activator

A family of serine proteases that catalyze the proteolytic conversion of plasminogen to plasmin. [from NCI]

MedGen UID:
18508
Concept ID:
C0032144
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
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