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Deacetylation

MedGen UID:
268332
Concept ID:
C1511737
Molecular Function
 

Definition

Deacetylation is the covalent chemical or post-translational biochemical removal of an acetyl group(s) from organic compounds. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeacetylation

Recent clinical studies

Etiology

Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K
Biochem Biophys Res Commun 2017 Aug 19;490(2):423-428. Epub 2017 Jun 14 doi: 10.1016/j.bbrc.2017.06.057. PMID: 28623141
Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE
Mol Cell 2017 Jan 19;65(2):296-309. Epub 2017 Jan 5 doi: 10.1016/j.molcel.2016.12.002. PMID: 28065600
Wang Y, Li F, Zhang G, Kang L, Guan H
Clin Epigenetics 2016;8:62. Epub 2016 May 26 doi: 10.1186/s13148-016-0229-y. PMID: 27231489Free PMC Article
Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan KL
PLoS Biol 2015;13(9):e1002243. Epub 2015 Sep 10 doi: 10.1371/journal.pbio.1002243. PMID: 26356530Free PMC Article
Chokboribal J, Tachaboonyakiat W, Sangvanich P, Ruangpornvisuti V, Jettanacheawchankit S, Thunyakitpisal P
Carbohydr Polym 2015 Nov 20;133:556-66. Epub 2015 Jul 17 doi: 10.1016/j.carbpol.2015.07.039. PMID: 26344314

Diagnosis

Sabir MS, Khan Z, Hu C, Galligan MA, Dussik CM, Mallick S, Stone AD, Batie SF, Jacobs ET, Whitfield GK, Haussler MR, Heck MC, Jurutka PW
J Steroid Biochem Mol Biol 2017 Sep;172:117-129. Epub 2017 Jun 19 doi: 10.1016/j.jsbmb.2017.06.010. PMID: 28636886Free PMC Article
Li F, Wu R, Cui X, Zha L, Yu L, Shi H, Xue B
J Biol Chem 2016 Feb 26;291(9):4523-36. Epub 2016 Jan 5 doi: 10.1074/jbc.M115.677930. PMID: 26733201Free PMC Article
Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM
J Biol Chem 2016 Jan 1;291(1):198-214. Epub 2015 Oct 9 doi: 10.1074/jbc.M115.668673. PMID: 26453307Free PMC Article
Suematsu T, Li Y, Kojima H, Nakajima K, Oshimura M, Inoue T
Biochem Biophys Res Commun 2014 Oct 24;453(3):588-94. Epub 2014 Oct 5 doi: 10.1016/j.bbrc.2014.09.128. PMID: 25285631
Yu SL, Lee DC, Son JW, Park CG, Lee HY, Kang J
Oncol Rep 2013 Sep;30(3):1293-300. Epub 2013 Jul 1 doi: 10.3892/or.2013.2578. PMID: 23817620

Therapy

Deng Z, Jin J, Wang Z, Wang Y, Gao Q, Zhao J
Int J Nanomedicine 2017;12:3617-3636. Epub 2017 May 10 doi: 10.2147/IJN.S124661. PMID: 28553103Free PMC Article
Pace E, Di Vincenzo S, Ferraro M, Siena L, Chiappara G, Dino P, Vitulo P, Bertani A, Saibene F, Lanata L, Gjomarkaj M
J Cell Physiol 2017 Oct;232(10):2851-2859. Epub 2017 Mar 31 doi: 10.1002/jcp.25710. PMID: 27925185
Zhao Z, Zhang X, Wen L, Yi S, Hu J, Ruan J, Zhao F, Cui G, Fang J, Chen Y
Eur J Pharmacol 2016 Oct 15;789:46-59. Epub 2016 Jun 29 doi: 10.1016/j.ejphar.2016.06.048. PMID: 27370960
Zahnow CA, Topper M, Stone M, Murray-Stewart T, Li H, Baylin SB, Casero RA Jr
Adv Cancer Res 2016;130:55-111. Epub 2016 Mar 2 doi: 10.1016/bs.acr.2016.01.007. PMID: 27037751
Zhao K, Zhou Y, Qiao C, Ni T, Li Z, Wang X, Guo Q, Lu N, Wei L
J Hematol Oncol 2015 Apr 23;8:41. doi: 10.1186/s13045-015-0137-1. PMID: 25902914Free PMC Article

Prognosis

Park SH, Ozden O, Liu G, Song HY, Zhu Y, Yan Y, Zou X, Kang HJ, Jiang H, Principe DR, Cha YI, Roh M, Vassilopoulos A, Gius D
Cancer Res 2016 Jul 1;76(13):3802-12. Epub 2016 Apr 27 doi: 10.1158/0008-5472.CAN-15-2498. PMID: 27197174Free PMC Article
Dasgupta T, Antony J, Braithwaite AW, Horsfield JA
J Biol Chem 2016 Jun 10;291(24):12761-70. Epub 2016 Apr 12 doi: 10.1074/jbc.M115.704627. PMID: 27072133Free PMC Article
Chang YW, Tseng CF, Wang MY, Chang WC, Lee CC, Chen LT, Hung MC, Su JL
Oncogene 2016 Mar 24;35(12):1517-28. Epub 2015 Jun 29 doi: 10.1038/onc.2015.214. PMID: 26119938
Toro TB, Watt TJ
Protein Sci 2015 Dec;24(12):2020-32. Epub 2015 Oct 7 doi: 10.1002/pro.2813. PMID: 26402585Free PMC Article
Kurokawa T, Fukami T, Nakajima M
Drug Metab Dispos 2015 Aug;43(8):1218-25. Epub 2015 May 15 doi: 10.1124/dmd.115.064089. PMID: 25979260

Clinical prediction guides

Jóźwiak T, Filipkowska U, Szymczyk P, Zyśk M
Int J Biol Macromol 2017 Feb;95:1169-1178. Epub 2016 Nov 5 doi: 10.1016/j.ijbiomac.2016.11.007. PMID: 27825998
Rafehi H, Karagiannis TC, El-Osta A
Curr Top Med Chem 2017;17(14):1611-1622. doi: 10.2174/1568026617666161104104341. PMID: 27823568
Zhao Z, Zhang X, Wen L, Yi S, Hu J, Ruan J, Zhao F, Cui G, Fang J, Chen Y
Eur J Pharmacol 2016 Oct 15;789:46-59. Epub 2016 Jun 29 doi: 10.1016/j.ejphar.2016.06.048. PMID: 27370960
Kurokawa T, Fukami T, Nakajima M
Drug Metab Dispos 2015 Aug;43(8):1218-25. Epub 2015 May 15 doi: 10.1124/dmd.115.064089. PMID: 25979260
Chuang C, Pan J, Hawke DH, Lin SH, Yu-Lee LY
PLoS One 2013;8(9):e73841. Epub 2013 Sep 19 doi: 10.1371/journal.pone.0073841. PMID: 24069238Free PMC Article

Recent systematic reviews

Corlăţeanu A, Odajiu I, Botnaru V, Cemirtan S
Pneumologia 2016 Jan-Mar;65(1):20-3. PMID: 27209836
Shyamasundar S, Dheen ST, Bay BH
Curr Med Chem 2016;23(2):186-97. PMID: 26549431
Liu XJ
Cell Tissue Res 2016 Jan;363(1):57-68. Epub 2015 Sep 2 doi: 10.1007/s00441-015-2264-y. PMID: 26329301
Masetti R, Serravalle S, Biagi C, Pession A
J Biomed Biotechnol 2011;2011:148046. Epub 2011 Jan 13 doi: 10.1155/2011/148046. PMID: 21318168Free PMC Article
Mai A, Massa S, Rotili D, Cerbara I, Valente S, Pezzi R, Simeoni S, Ragno R
Med Res Rev 2005 May;25(3):261-309. doi: 10.1002/med.20024. PMID: 15717297

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