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Mitogens

MedGen UID:
7665
Concept ID:
C0026249
Pharmacologic Substance
Synonyms: Mitogen
 

Definition

A soluble substance, usually a protein, that induces mitosis in resting cells, thereby causing cell proliferation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMitogens

Recent clinical studies

Etiology

Rigolin GM, del Giudice I, Formigaro L, Saccenti E, Martinelli S, Cavallari M, Lista E, Tammiso E, Volta E, Lupini L, Bassi C, Bardi A, Sofritti O, Daghia G, Cavazzini F, Marinelli M, Tavolaro S, Guarini A, Negrini M, Foà R, Cuneo A
Genes Chromosomes Cancer 2015 Dec;54(12):818-26. Epub 2015 Sep 10 doi: 10.1002/gcc.22293. PMID: 26355802
Rigolin GM, Cibien F, Martinelli S, Formigaro L, Rizzotto L, Tammiso E, Saccenti E, Bardi A, Cavazzini F, Ciccone M, Nichele I, Pizzolo G, Zaja F, Fanin R, Galieni P, Dalsass A, Mestichelli F, Testa N, Negrini M, Cuneo A
Blood 2012 Mar 8;119(10):2310-3. Epub 2012 Jan 13 doi: 10.1182/blood-2011-11-395269. PMID: 22246039
Stone J, Folkerd E, Doody D, Schroen C, Treloar SA, Giles GG, Pike MC, English DR, Southey MC, Hopper JL, Dowsett M
J Clin Endocrinol Metab 2009 Dec;94(12):4793-800. Epub 2009 Oct 22 doi: 10.1210/jc.2009-0713. PMID: 19850695
Stone KD, Feldman HA, Huisman C, Howlett C, Jabara HH, Bonilla FA
Clin Immunol 2009 Apr;131(1):41-9. Epub 2009 Jan 1 doi: 10.1016/j.clim.2008.11.003. PMID: 19121607
Boyd NF, Stone J, Martin LJ, Jong R, Fishell E, Yaffe M, Hammond G, Minkin S
Br J Cancer 2002 Oct 7;87(8):876-82. doi: 10.1038/sj.bjc.6600537. PMID: 12373602Free PMC Article

Diagnosis

Kuon RJ, Schaumann J, Goeggl T, Strowitzki T, Sadeghi M, Opelz G, Daniel V, Toth B
J Reprod Immunol 2015 Nov;112:82-7. Epub 2015 Sep 20 doi: 10.1016/j.jri.2015.08.006. PMID: 26398781
Ma SK, Wang Y, Chen J, Zhang MZ, Harris RC, Chen JK
PLoS One 2015;10(2):e0113130. Epub 2015 Feb 13 doi: 10.1371/journal.pone.0113130. PMID: 25679385Free PMC Article
Brown KL, Palyvoda OY, Auner GW, Gruber SA
J Immunol Methods 2014 Dec 15;415:31-5. Epub 2014 Oct 20 doi: 10.1016/j.jim.2014.10.001. PMID: 25450257
Stone KD, Feldman HA, Huisman C, Howlett C, Jabara HH, Bonilla FA
Clin Immunol 2009 Apr;131(1):41-9. Epub 2009 Jan 1 doi: 10.1016/j.clim.2008.11.003. PMID: 19121607
Pinzón-Charry A, Vernot JP, Rodríguez R, Patarroyo ME
J Med Primatol 2003 Feb;32(1):31-8. PMID: 12733600

Therapy

Kuon RJ, Schaumann J, Goeggl T, Strowitzki T, Sadeghi M, Opelz G, Daniel V, Toth B
J Reprod Immunol 2015 Nov;112:82-7. Epub 2015 Sep 20 doi: 10.1016/j.jri.2015.08.006. PMID: 26398781
Jawaid K, Crane SR, Nowers JL, Lacey M, Whitehead SA
J Steroid Biochem Mol Biol 2010 Jun;120(4-5):164-71. Epub 2010 Apr 23 doi: 10.1016/j.jsbmb.2010.04.007. PMID: 20399854
Schwindt TT, Motta FL, Barnabé GF, Massant CG, Guimarães Ade O, Calcagnotto ME, Conceição FS, Pesquero JB, Rehen S, Mello LE
PLoS One 2009;4(2):e4642. Epub 2009 Feb 27 doi: 10.1371/journal.pone.0004642. PMID: 19247499Free PMC Article
Harita S, Kuyama S, Okada T, Tanizaki Y
J Chemother 2008 Oct;20(5):604-8. doi: 10.1179/joc.2008.20.5.604. PMID: 19028624
Wang C, Li Z, Fu M, Bouras T, Pestell RG
Cancer Treat Res 2004;119:217-37. PMID: 15164880

Prognosis

Rigolin GM, del Giudice I, Formigaro L, Saccenti E, Martinelli S, Cavallari M, Lista E, Tammiso E, Volta E, Lupini L, Bassi C, Bardi A, Sofritti O, Daghia G, Cavazzini F, Marinelli M, Tavolaro S, Guarini A, Negrini M, Foà R, Cuneo A
Genes Chromosomes Cancer 2015 Dec;54(12):818-26. Epub 2015 Sep 10 doi: 10.1002/gcc.22293. PMID: 26355802
Rigolin GM, Cibien F, Martinelli S, Formigaro L, Rizzotto L, Tammiso E, Saccenti E, Bardi A, Cavazzini F, Ciccone M, Nichele I, Pizzolo G, Zaja F, Fanin R, Galieni P, Dalsass A, Mestichelli F, Testa N, Negrini M, Cuneo A
Blood 2012 Mar 8;119(10):2310-3. Epub 2012 Jan 13 doi: 10.1182/blood-2011-11-395269. PMID: 22246039
Kelly JJ, Stechishin O, Chojnacki A, Lun X, Sun B, Senger DL, Forsyth P, Auer RN, Dunn JF, Cairncross JG, Parney IF, Weiss S
Stem Cells 2009 Aug;27(8):1722-33. doi: 10.1002/stem.98. PMID: 19544433
Stone KD, Feldman HA, Huisman C, Howlett C, Jabara HH, Bonilla FA
Clin Immunol 2009 Apr;131(1):41-9. Epub 2009 Jan 1 doi: 10.1016/j.clim.2008.11.003. PMID: 19121607
Matusiak D, Glover S, Nathaniel R, Matkowskyj K, Yang J, Benya RV
Am J Physiol Gastrointest Liver Physiol 2005 Apr;288(4):G718-28. Epub 2004 Nov 4 doi: 10.1152/ajpgi.00156.2004. PMID: 15528253

Clinical prediction guides

Rigolin GM, del Giudice I, Formigaro L, Saccenti E, Martinelli S, Cavallari M, Lista E, Tammiso E, Volta E, Lupini L, Bassi C, Bardi A, Sofritti O, Daghia G, Cavazzini F, Marinelli M, Tavolaro S, Guarini A, Negrini M, Foà R, Cuneo A
Genes Chromosomes Cancer 2015 Dec;54(12):818-26. Epub 2015 Sep 10 doi: 10.1002/gcc.22293. PMID: 26355802
Rigolin GM, Cibien F, Martinelli S, Formigaro L, Rizzotto L, Tammiso E, Saccenti E, Bardi A, Cavazzini F, Ciccone M, Nichele I, Pizzolo G, Zaja F, Fanin R, Galieni P, Dalsass A, Mestichelli F, Testa N, Negrini M, Cuneo A
Blood 2012 Mar 8;119(10):2310-3. Epub 2012 Jan 13 doi: 10.1182/blood-2011-11-395269. PMID: 22246039
Bala K, Ambwani K, Gohil NK
Tissue Cell 2011 Aug;43(4):216-22. Epub 2011 Apr 20 doi: 10.1016/j.tice.2011.03.004. PMID: 21511321
Matusiak D, Glover S, Nathaniel R, Matkowskyj K, Yang J, Benya RV
Am J Physiol Gastrointest Liver Physiol 2005 Apr;288(4):G718-28. Epub 2004 Nov 4 doi: 10.1152/ajpgi.00156.2004. PMID: 15528253
Kaspar D, Neidlinger-Wilke C, Holbein O, Claes L, Ignatius A
J Orthop Res 2003 Mar;21(2):320-5. doi: 10.1016/S0736-0266(02)00134-1. PMID: 12568965

Recent systematic reviews

Gu D, Wang M
Breast Cancer Res Treat 2011 Jan;125(2):489-93. Epub 2010 Jun 19 doi: 10.1007/s10549-010-0991-z. PMID: 20563637
Paulus JM, Levin J, Debili N, Albert A, Vainchenker W
Exp Hematol 2001 Nov;29(11):1256-69. PMID: 11698121
Wimer BM
Cancer Biother Radiopharm 1998 Apr;13(2):109-20. doi: 10.1089/cbr.1998.13.109. PMID: 10850347
Herbert TB, Cohen S
Psychol Bull 1993 May;113(3):472-86. PMID: 8316610
Darko DF, Wilson NW, Gillin JC, Golshan S
Am J Psychiatry 1991 Mar;148(3):337-44. doi: 10.1176/ajp.148.3.337. PMID: 1992836

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