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Items: 9

1.

Receptor Binding

Receptor Binding involves a temporary non-covalent, typically highly specific and high affinity, interaction through intermolecular physical forces of attraction and spatial complementarity with a diverse group of intrinsic membrane or cytoplasmic proteins that mediate the biological effects of secreted regulatory signaling molecules through modification of the activity of signal transduction pathways. [from NCI]

MedGen UID:
154572
Concept ID:
C0597358
Molecular Function
2.

Hiv

Infection caused by the human immunodeficiency virus. [from NCI_NICHD]

MedGen UID:
5583
Concept ID:
C0019693
Disease or Syndrome
3.

HIV Infections

MedGen UID:
880960
Concept ID:
CN236632
Disease or Syndrome
4.

Human immunodeficiency virus

MedGen UID:
842721
Concept ID:
C3854222
Disease or Syndrome
5.

Infections

MedGen UID:
678472
Concept ID:
C0851162
Disease or Syndrome
6.

Immunodeficiency

A deficiency of immune response or a disorder characterized by deficient immune response. [from NCI_FDA]

MedGen UID:
7034
Concept ID:
C0021051
Disease or Syndrome
7.

VP-2

MedGen UID:
57339
Concept ID:
C0148584
Organic Chemical; Pharmacologic Substance
8.

recombinant soluble CD4

A recombinant form of CD4 antigen with anti-HIV application. Recombinant soluble T4 antigen (rsT4) is derived from cell surface antigen CD4 lacking its transmembrane and cytoplasmic domains, thereby the agent is mobile within tissues. rsT4 binds to the envelope glycoprotein gp110 of HIV and prevents the binding of virus to CD4 positive lymphocytes, resulting in an inhibition of virus infectivity. [from NCI]

MedGen UID:
60482
Concept ID:
C0210233
Amino Acid, Peptide, or Protein; Pharmacologic Substance
9.

recombinant soluble human CD4 protein

A recombinant human soluble CD4 with antiviral activity. Recombinant human soluble CD4 has the amino terminus but not the T-cell binding domain of the endogenous CD4 antigen. This soluble CD4 protein competitively binds to envelope glycoprotein (gp120) of human immunodeficiency virus (HIV) resulting in inhibition of interaction between gp120 and the endogenous CD4 antigen, thereby blocking viral recognition of CD4 and subsequent entry of HIV into CD4 bearing cells. [from NCI]

MedGen UID:
78929
Concept ID:
C0279074
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
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