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Items: 9

1.

Frequency

MedGen UID:
91210
Concept ID:
C0376249
Temporal Concept
2.

Frequency

MedGen UID:
1381421
Concept ID:
C4321352
Intellectual Product
3.

Replication Error

A Replication Error results from the covalent addition of an incorrect nucleotide subunit, or the lack of addition of a nucleotide subunit, during polymerization of the growing newly synthesized DNA strand during replication. (NCI) [from NCI]

MedGen UID:
271105
Concept ID:
C1514850
Cell or Molecular Dysfunction
4.

Thioguanine

A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04) [from NCI]

MedGen UID:
21146
Concept ID:
C0039902
Organic Chemical; Pharmacologic Substance
5.

Guanidine

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. [from MeSH]

MedGen UID:
92574
Concept ID:
C0120446
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
6.

Thioguanine Anhydrous

The anhydrous salt form of thioguanine, a synthetic guanosine analogue antimetabolite, with antineoplastic activity. Thioguanine is phosphorylated by hypoxanthine-guanine phosphoribosyltransferase to 6-thioguanylic acid (TGMP) and upon conversion to thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP), this agent is incorporated into DNA and RNA, resulting in inhibition of DNA and RNA synthesis and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine ribonulceotide synthesis. [from NCI]

MedGen UID:
364829
Concept ID:
C1883309
Organic Chemical; Pharmacologic Substance
7.

Tioguanina Wellcome

MedGen UID:
289815
Concept ID:
C1564403
Organic Chemical; Pharmacologic Substance
8.

Thioguanine Monosodium Salt

MedGen UID:
164374
Concept ID:
C0886925
Organic Chemical; Pharmacologic Substance
9.

Thioguanine Hemihydrate

MedGen UID:
164373
Concept ID:
C0886924
Organic Chemical; Pharmacologic Substance
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