Format

Send to:

Choose Destination

Links from PubMed

Motor tics

MedGen UID:
199761
Concept ID:
C0751900
Sign or Symptom
Synonyms: Motor Tic; Motor Tics; Tic, Motor; Tics, Motor
 
HPO: HP:0100034

Definition

Movement-based tics affecting discrete muscle groups. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMotor tics

Conditions with this feature

Pigmentary pallidal degeneration
MedGen UID:
6708
Concept ID:
C0018523
Disease or Syndrome
Pantothenate kinase-associated neurodegeneration (PKAN) is a form of neurodegeneration with brain iron accumulation, or NBIA (formerly called Hallervorden-Spatz syndrome). PKAN is characterized by progressive dystonia and basal ganglia iron deposition with onset that usually occurs before age ten years. Commonly associated features include dysarthria, rigidity, and pigmentary retinopathy. Approximately 25% of affected individuals have an 'atypical' presentation with later onset (age >10 years), prominent speech defects, psychiatric disturbances, and more gradual progression of disease.
Tourette Syndrome
MedGen UID:
21219
Concept ID:
C0040517
Disease or Syndrome
Tourette syndrome is a neurobehavioral disorder manifest particularly by motor and vocal tics and associated with behavioral abnormalities. Tics are sudden, brief, intermittent, involuntary or semi-voluntary movements (motor tics) or sounds (phonic or vocal tics). They typically consist of simple, coordinated, repetitive movements, gestures, or utterances that mimic fragments of normal behavior. Motor tics may range from simple blinking, nose twitching, and head jerking to more complex throwing, hitting, or making rude gestures. Phonic tics include sniffling, throat clearing, blowing, coughing, echolalia, or coprolalia. Males are affected about 3 times more often than females, and onset usually occurs between 3 and 8 years of age. By age 18 years, more than half of affected individuals are free of tics, but they may persist into adulthood (review by Jankovic, 2001).
Autism, susceptibility to, X-linked 4
MedGen UID:
162886
Concept ID:
C0795888
Disease or Syndrome
Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior (Bailey et al., 1996; Risch et al., 1999). 'Autism spectrum disorder,' sometimes referred to as ASD, is a broader phenotype encompassing the less severe disorders Asperger syndrome (see ASPG1; 608638) and pervasive developmental disorder, not otherwise specified (PDD-NOS). 'Broad autism phenotype' includes individuals with some symptoms of autism, but who do not meet the full criteria for autism or other disorders. Mental retardation coexists in approximately two-thirds of individuals with ASD, except for Asperger syndrome, in which mental retardation is conspicuously absent (Jones et al., 2008). Genetic studies in autism often include family members with these less stringent diagnoses (Schellenberg et al., 2006). Levy et al. (2009) provided a general review of autism and autism spectrum disorder, including epidemiology, characteristics of the disorder, diagnosis, neurobiologic hypotheses for the etiology, genetics, and treatment options.
Idiopathic basal ganglia calcification 5
MedGen UID:
815975
Concept ID:
C3809645
Disease or Syndrome
Idiopathic basal ganglia calcification-5 (IBGC5) is an autosomal dominant disorder characterized by progressive neurologic symptoms that are associated with brain calcifications mainly affecting the basal ganglia. Calcifications may also occur in the thalamus, cerebellum, or white matter. Affected individuals have motor symptoms, such as dyskinesias or parkinsonism, headache, cognitive impairment, and psychiatric manifestations, including apathy and depression. Some patients are asymptomatic. The age at symptom onset ranges from late childhood to adulthood; the disorder is progressive (summary by Keller et al., 2013). For a detailed phenotypic description and a discussion of genetic heterogeneity of IBGC, see IBGC1 (213600).

Recent clinical studies

Etiology

Rath JJ, Tavy DL, Wertenbroek AA, van Woerkom TC, de Bruijn SF
Parkinsonism Relat Disord 2010 Aug;16(7):478-81. Epub 2010 Jan 19 doi: 10.1016/j.parkreldis.2009.11.011. PMID: 20034838
Hampson M, Tokoglu F, King RA, Constable RT, Leckman JF
Biol Psychiatry 2009 Apr 1;65(7):594-9. Epub 2008 Dec 25 doi: 10.1016/j.biopsych.2008.11.012. PMID: 19111281Free PMC Article
Snider LA, Seligman LD, Ketchen BR, Levitt SJ, Bates LR, Garvey MA, Swedo SE
Pediatrics 2002 Aug;110(2 Pt 1):331-6. PMID: 12165586
Marras C, Andrews D, Sime E, Lang AE
Neurology 2001 Mar 13;56(5):605-10. PMID: 11245710
Brett PM, Curtis D, Robertson MM, Gurling HM
Am J Psychiatry 1995 Mar;152(3):437-40. doi: 10.1176/ajp.152.3.437. PMID: 7864272

Diagnosis

Neal M, Cavanna AE
Psychiatry Res 2013 Dec 15;210(2):559-63. Epub 2013 Jul 10 doi: 10.1016/j.psychres.2013.06.033. PMID: 23850205
Ko DY, Kim SK, Chae JH, Wang KC, Phi JH
Childs Nerv Syst 2013 Feb;29(2):317-21. Epub 2012 Oct 7 doi: 10.1007/s00381-012-1939-x. PMID: 23053364
Bernabei M, Preatoni E, Mendez M, Piccini L, Porta M, Andreoni G
Mov Disord 2010 Sep 15;25(12):1967-72. doi: 10.1002/mds.23188. PMID: 20669298
Fan PC, Huang WJ, Chiou LC
J Child Neurol 2009 Jul;24(7):887-90. doi: 10.1177/0883073808331088. PMID: 19617461
Crosland KA, Zarcone JR, Schroeder S, Zarcone T, Fowler S
Am J Ment Retard 2005 May;110(3):181-92. doi: 10.1352/0895-8017(2005)110<181:UOAAAA>2.0.CO;2. PMID: 15804194

Therapy

Hsieh MH, Chiu NY
Gen Hosp Psychiatry 2014 May-Jun;36(3):360.e7-8. Epub 2014 Jan 14 doi: 10.1016/j.genhosppsych.2014.01.003. PMID: 24556260
Anam PS, Coffey DB
J Child Adolesc Psychopharmacol 2013 Oct;23(8):577-82. doi: 10.1089/cap.2013.2382. PMID: 24138012
Rath JJ, Tavy DL, Wertenbroek AA, van Woerkom TC, de Bruijn SF
Parkinsonism Relat Disord 2010 Aug;16(7):478-81. Epub 2010 Jan 19 doi: 10.1016/j.parkreldis.2009.11.011. PMID: 20034838
Fan PC, Huang WJ, Chiou LC
J Child Neurol 2009 Jul;24(7):887-90. doi: 10.1177/0883073808331088. PMID: 19617461
Linazasoro G, Van Blercom N
Parkinsonism Relat Disord 2007 Feb;13(1):57-8. Epub 2006 Jul 5 doi: 10.1016/j.parkreldis.2006.03.007. PMID: 16822697

Prognosis

Huys D, Bartsch C, Koester P, Lenartz D, Maarouf M, Daumann J, Mai JK, Klosterkötter J, Hunsche S, Visser-Vandewalle V, Woopen C, Timmermann L, Sturm V, Kuhn J
Biol Psychiatry 2016 Mar 1;79(5):392-401. Epub 2014 Jun 2 doi: 10.1016/j.biopsych.2014.05.014. PMID: 25034948
Draper A, Stephenson MC, Jackson GM, Pépés S, Morgan PS, Morris PG, Jackson SR
Curr Biol 2014 Oct 6;24(19):2343-7. Epub 2014 Sep 25 doi: 10.1016/j.cub.2014.08.038. PMID: 25264251Free PMC Article
Steinberg T, Shmuel-Baruch S, Horesh N, Apter A
Compr Psychiatry 2013 Jul;54(5):467-73. Epub 2012 Dec 6 doi: 10.1016/j.comppsych.2012.10.015. PMID: 23219489
Rath JJ, Tavy DL, Wertenbroek AA, van Woerkom TC, de Bruijn SF
Parkinsonism Relat Disord 2010 Aug;16(7):478-81. Epub 2010 Jan 19 doi: 10.1016/j.parkreldis.2009.11.011. PMID: 20034838
Hampson M, Tokoglu F, King RA, Constable RT, Leckman JF
Biol Psychiatry 2009 Apr 1;65(7):594-9. Epub 2008 Dec 25 doi: 10.1016/j.biopsych.2008.11.012. PMID: 19111281Free PMC Article

Clinical prediction guides

Neal M, Cavanna AE
Psychiatry Res 2013 Dec 15;210(2):559-63. Epub 2013 Jul 10 doi: 10.1016/j.psychres.2013.06.033. PMID: 23850205
Ko DY, Kim SK, Chae JH, Wang KC, Phi JH
Childs Nerv Syst 2013 Feb;29(2):317-21. Epub 2012 Oct 7 doi: 10.1007/s00381-012-1939-x. PMID: 23053364
Bernabei M, Preatoni E, Mendez M, Piccini L, Porta M, Andreoni G
Mov Disord 2010 Sep 15;25(12):1967-72. doi: 10.1002/mds.23188. PMID: 20669298
Fan PC, Huang WJ, Chiou LC
J Child Neurol 2009 Jul;24(7):887-90. doi: 10.1177/0883073808331088. PMID: 19617461
Crosland KA, Zarcone JR, Schroeder S, Zarcone T, Fowler S
Am J Ment Retard 2005 May;110(3):181-92. doi: 10.1352/0895-8017(2005)110<181:UOAAAA>2.0.CO;2. PMID: 15804194

Recent systematic reviews

Waldon K, Hill J, Termine C, Balottin U, Cavanna AE
Behav Neurol 2013;26(4):265-73. doi: 10.3233/BEN-2012-120269. PMID: 22713420Free PMC Article
Simpson DM, Blitzer A, Brashear A, Comella C, Dubinsky R, Hallett M, Jankovic J, Karp B, Ludlow CL, Miyasaki JM, Naumann M, So Y; Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
Neurology 2008 May 6;70(19):1699-706. doi: 10.1212/01.wnl.0000311389.26145.95. PMID: 18458230

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    Support Center