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Items: 18

1.

Digoxigenin

3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. A cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh. [from MeSH]

MedGen UID:
4298
Concept ID:
C0012264
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
2.

Vesicle

A small (less than 1 cm) fluid-filled lesion, raised above the plane of surrounding skin [from SNOMEDCT_US]

MedGen UID:
568991
Concept ID:
C0333262
Disease or Syndrome
3.

Leukoencephalopathy, brain calcifications, and cysts

Leukoencephalopathy, brain calcifications, and cysts (LCC), also known as Labrune syndrome, is characterized by a constellation of features restricted to the central nervous system, including leukoencephalopathy, brain calcifications, and cysts, resulting in spasticity, dystonia, seizures, and cognitive decline (summary by Labrune et al., 1996). See also cerebroretinal microangiopathy with calcifications and cysts (CRMCC; 612199), an autosomal recessive disorder caused by mutation in the CTC1 gene (613129) that shows phenotypic similarities to Labrune syndrome. CRMCC includes the neurologic findings of intracranial calcifications, leukodystrophy, and brain cysts, but also includes retinal vascular abnormalities and other systemic manifestations, such as osteopenia with poor bone healing, a high risk of gastrointestinal bleeding, hair, skin, and nail changes, and anemia and thrombocytopenia. Although Coats plus syndrome and Labrune syndrome were initially thought to be manifestations of the same disorder, namely CRMCC, molecular evidence has excluded mutations in the CTC1 gene in patients with Labrune syndrome, suggesting that the 2 disorders are not allelic (Anderson et al., 2012; Polvi et al., 2012). [from GTR]

MedGen UID:
482830
Concept ID:
C3281200
Disease or Syndrome
4.

Hepatocellular carcinoma

Hepatocellular carcinoma is the major histologic type of malignant primary liver neoplasm. It is the fifth most common cancer and the third most common cause of death from cancer worldwide. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Hepatoblastomas comprise 1 to 2% of all malignant neoplasms of childhood, most often occurring in children under 3 years of age. Hepatoblastomas are thought to be derived from undifferentiated hepatocytes (Taniguchi et al., 2002). [from GTR]

MedGen UID:
389187
Concept ID:
C2239176
Neoplastic Process
5.

Staining

MedGen UID:
352872
Concept ID:
C1704680
Finding
6.

Digacin

MedGen UID:
344926
Concept ID:
C1569328
Organic Chemical; Pharmacologic Substance
7.

Digoregen

MedGen UID:
344925
Concept ID:
C1569327
Organic Chemical; Pharmacologic Substance
8.

Lanacordin

MedGen UID:
298456
Concept ID:
C1569324
Organic Chemical; Pharmacologic Substance
9.

Lanicor

MedGen UID:
292211
Concept ID:
C1569323
Organic Chemical; Pharmacologic Substance
10.

Mapluxin

MedGen UID:
292210
Concept ID:
C1569322
Organic Chemical; Pharmacologic Substance
11.

Dilanacin

MedGen UID:
196133
Concept ID:
C0701373
Organic Chemical; Pharmacologic Substance
12.

Lanoxin

MedGen UID:
195957
Concept ID:
C0699988
Organic Chemical; Pharmacologic Substance
13.

Digitek

MedGen UID:
163738
Concept ID:
C0876017
Organic Chemical; Pharmacologic Substance
14.

Lanoxicaps

MedGen UID:
148757
Concept ID:
C0701372
Organic Chemical; Pharmacologic Substance
15.

Sex hormone

A class of steroid hormones that specifically binds to and activates androgen, progesterone or estrogen receptors. Sex steroids activate various signaling pathways involved in the development and maintenance of secondary sexual characteristics, reproductive processes, blood salt balance, response to stress, neuronal function and a number of metabolic processes. [from NCI]

MedGen UID:
19951
Concept ID:
C0036884
Hormone; Pharmacologic Substance
16.

Digoxin

A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04) [from NCI]

MedGen UID:
4299
Concept ID:
C0012265
Organic Chemical; Pharmacologic Substance
17.

Antibody Specificity

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site. [from MeSH]

MedGen UID:
1586
Concept ID:
C0003264
Molecular Function
18.

Glycoside

Any compound in which a sugar group is covalently bonded through its anomeric carbon to another group via an O-glycosidic bond or an S-glycosidic bond; glycosides involving the latter are also called thioglycosides. However, substances containing N-glycosidic bonds, where the anomeric carbon is bound to some other group via a nitrogen atom, are called glycosylamines; the term "N-glycoside" is considered a misnomer by IUPAC and is discouraged. Furthermore, the sugar group needs to be bonded to a non-sugar for the molecule to qualify as a glycoside, thus excluding the polysaccharides. The sugar group in glycosides is known as the glycone, which can be a single sugar group (monosaccharide) or several sugar groups (oligosaccharide); the non-sugar group is known as the aglycone or genin. [from NCI]

MedGen UID:
770
Concept ID:
C0007158
Organic Chemical; Pharmacologic Substance
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