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Items: 1 to 20 of 33

1.

Recurrence (disease attribute)

The return of a sign, symptom, or disease after a remission. [from MeSH]

MedGen UID:
416712
Concept ID:
C2825055
Pathologic Function
2.

Myxoid liposarcoma

Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion (review by Dei Tos, 2000). [from OMIM]

MedGen UID:
104903
Concept ID:
C0206634
Neoplastic Process
3.

Pleomorphic Liposarcoma

A liposarcoma characterized by the presence of varying proportions of pleomorphic lipoblasts in a background that resembles undifferentiated pleomorphic sarcoma. It is the rarest liposarcoma variant and usually has an aggressive clinical course. [from NCI]

MedGen UID:
61457
Concept ID:
C0205825
Neoplastic Process
4.

Hibernoma

A rare benign slow growing adipose tissue tumor, characterized by the presence of polygonal brown fat cells with multivacuolated and/or granular cytoplasm. The tumor is usually painless and is most often seen in young adults. [from NCI]

MedGen UID:
61456
Concept ID:
C0205822
Neoplastic Process
5.

Dedifferentiated Liposarcoma

An atypical lipomatous tumor/well differentiated liposarcoma that shows progression to a usually non-lipomatous, high grade sarcoma. The non-lipomatous sarcoma component may be present in the primary lesion or at the site of recurrence. [from NCI]

MedGen UID:
60028
Concept ID:
C0205824
Neoplastic Process
6.

Liposarcoma

Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. [from HPO]

MedGen UID:
44177
Concept ID:
C0023827
Neoplastic Process
7.

Lipoma

Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. [from HPO]

MedGen UID:
44173
Concept ID:
C0023798
Neoplastic Process
8.

Diagnosis

Description:The source act is intended to help establish the presence of a (an adverse) situation described by the target act. This is not limited to diseases but can apply to any adverse situation or condition of medical or technical nature.  [from HL7]

MedGen UID:
8354
Concept ID:
C0011900
Finding
9.

Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis

SOFT syndrome is characterized by severely short long bones, peculiar facies associated with paucity of hair, and nail anomalies. Growth retardation is evident on prenatal ultrasound as early as the second trimester of pregnancy, and affected individuals reach a final stature consistent with a height age of 6 years to 8 years. Relative macrocephaly is present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is normal. Facial dysmorphism includes a long, triangular face with prominent nose and small ears, and affected individuals have an unusual high-pitched voice. Clinodactyly, brachydactyly, and hypoplastic distal phalanges and fingernails are present in association with postpubertal sparse and short hair. Typical skeletal findings include short and thick long bones with mild irregular metaphyseal changes, short femoral necks, and hypoplastic pelvis and sacrum. All long bones of the hand are short, with major delay of carpal ossification and cone-shaped epiphyses. Vertebral body ossification is also delayed (summary by Sarig et al., 2012). [from OMIM]

MedGen UID:
762199
Concept ID:
C3542022
Disease or Syndrome
10.

Multiple lipomas

The presence of multiple lipomas (a type of benign tissue made of fatty tissue). [from HPO]

MedGen UID:
677074
Concept ID:
C0745730
Finding; Neoplastic Process
11.

Myxoid liposarcoma

A liposarcoma that contains myxomatous tissue. [from HPO]

MedGen UID:
506720
Concept ID:
CN168788
Finding
12.

Lipomatosis, multiple

Familial multiple lipomatosis is a rare autosomal dominant disorder characterized by numerous encapsulated lipomas on the trunk and extremities (Keskin et al., 2002). [from OMIM]

MedGen UID:
483366
Concept ID:
C3489413
Neoplastic Process
13.

Well Differentiated Liposarcoma

A locally aggressive malignant neoplasm composed of mature adipocytes showing cell size variation and nuclear atypia. It is often associated with the presence of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. There are three histologic subtypes, sclerosing, inflammatory, and spindle cell liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation. [from NCI]

MedGen UID:
237164
Concept ID:
C1370889
Neoplastic Process
14.

Sarcoma

Your soft tissues connect, support, or surround other tissues. Examples include your muscles, tendons, fat, and blood vessels. Soft tissue sarcoma is a cancer of these soft tissues. There are many kinds, based on the type of tissue they started in. They may cause a lump or swelling in the soft tissue. Sometimes they spread and can press on nerves and organs, causing problems such as pain or trouble breathing. No one knows exactly what causes these cancers. They are not common, but you have a higher risk if you have been exposed to certain chemicals, have had radiation therapy, or have certain genetic diseases. Doctors diagnose soft tissue sarcomas with a biopsy. Treatments include surgery to remove the tumor, radiation therapy, chemotherapy, or a combination. NIH: National Cancer Institute.  [from MedlinePlus]

MedGen UID:
224714
Concept ID:
C1261473
Neoplastic Process
15.

atypia morphology

The condition of being irregular or not conforming to type. [from NCI]

MedGen UID:
152855
Concept ID:
C0741302
Finding
16.

Myxoid Liposarcoma

A liposarcoma characterized by the presence of round non-lipogenic primitive mesenchymal cells and small signet ring lipoblasts within a myxoid stoma with a branching vascular pattern. This category includes hypercellular lesions with round cell morphology, formerly known as round cell liposarcoma. [from NCI]

MedGen UID:
107784
Concept ID:
C0545074
Neoplastic Process
17.

Cytologic atypia

MedGen UID:
90720
Concept ID:
C0333865
Cell or Molecular Dysfunction
18.

Tumor Progression

A pathologic process in which alterations at the molecular level result in a more aggressive cytologic and phenotypic profile and clinical course of a neoplasm. [from NCI]

MedGen UID:
61255
Concept ID:
C0178874
Neoplastic Process
19.

Pleomorphic Lipoma

A benign circumscribed tumor characterized by small spindle cells, rounded hyperchromatic cells and multinucleated giant cells with radially arranged nuclei. [from NCI]

MedGen UID:
60027
Concept ID:
C0205823
Neoplastic Process
20.

Anaplastic Lesion

A morphologic finding indicating the presence of a malignant cellular infiltrate characterized by the presence of large pleomorphic cells, necrosis, and high mitotic activity in a tissue sample. [from NCI]

MedGen UID:
1903
Concept ID:
C0002793
Neoplastic Process
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