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antineoplaston AS 2-1

MedGen UID:
80539
Concept ID:
C0294295
Amino Acid, Peptide, or Protein; Pharmacologic Substance
Synonyms: antineoplaston AS2-1; antineoplaston AS21; AS2-1 antineoplaston
 

Definition

A 4:1 mixture of phenylacetate and phenylacetylgluatmine, degradation products of the antineoplaston agent A10. Antineoplaston AS2-1 inhibits the incorporation of L-glutamine into tumor-cell proteins, leading to cell cycle arrest in the G1 phase and inhibition of mitosis. This agent may also inhibit RAS oncogene expression and activate tumor suppressor gene p53, resulting in cell differentiation and apoptosis. (NCI04) [from NCI]

Recent clinical studies

Etiology

Burzynski SR, Burzynski GS, Janicki TJ, Marszalek A
Pediatr Neurosurg 2015;50(2):99-103. Epub 2015 Apr 22 doi: 10.1159/000369907. PMID: 25926271
Burzynski SR, Janicki TJ, Burzynski GS, Marszalek A
Childs Nerv Syst 2014 Dec;30(12):2051-61. Epub 2014 Apr 10 doi: 10.1007/s00381-014-2401-z. PMID: 24718705Free PMC Article
Burzynski SR, Janicki TJ, Weaver RA, Burzynski B
Integr Cancer Ther 2006 Mar;5(1):40-7. doi: 10.1177/1534735405285380. PMID: 16484713
Burzynski SR, Weaver RA, Janicki T, Szymkowski B, Jurida G, Khan M, Dolgopolov V
Integr Cancer Ther 2005 Jun;4(2):168-77. doi: 10.1177/1534735405276835. PMID: 15911929
Burzynski SR, Lewy RI, Weaver RA, Axler ML, Janicki TJ, Jurida GF, Paszkowiak JK, Szymkowski BG, Khan MI, Bestak M
Drugs R D 2003;4(2):91-101. PMID: 12718563

Diagnosis

Burzynski SR, Burzynski GS, Janicki TJ, Marszalek A
Pediatr Neurosurg 2015;50(2):99-103. Epub 2015 Apr 22 doi: 10.1159/000369907. PMID: 25926271
Burzynski SR, Janicki TJ, Burzynski GS, Marszalek A
Childs Nerv Syst 2014 Dec;30(12):2051-61. Epub 2014 Apr 10 doi: 10.1007/s00381-014-2401-z. PMID: 24718705Free PMC Article
Burzynski SR, Weaver RA, Janicki T, Szymkowski B, Jurida G, Khan M, Dolgopolov V
Integr Cancer Ther 2005 Jun;4(2):168-77. doi: 10.1177/1534735405276835. PMID: 15911929
Burzynski SR, Lewy RI, Weaver R, Janicki T, Jurida G, Khan M, Larisma CB, Paszkowiak J, Szymkowski B
Integr Cancer Ther 2004 Sep;3(3):257-61. doi: 10.1177/1534735404267748. PMID: 15312271
Hammer MR, Jonas WB
Integr Cancer Ther 2004 Mar;3(1):59-65. doi: 10.1177/1534735404263448. PMID: 15035877

Therapy

Burzynski SR, Burzynski GS, Janicki TJ, Marszalek A
Pediatr Neurosurg 2015;50(2):99-103. Epub 2015 Apr 22 doi: 10.1159/000369907. PMID: 25926271
Ogata Y, Matono K, Tsuda H, Ushijima M, Uchida S, Akagi Y, Shirouzu K
PLoS One 2015;10(3):e0120064. Epub 2015 Mar 19 doi: 10.1371/journal.pone.0120064. PMID: 25790229Free PMC Article
Di Rocco C
Childs Nerv Syst 2014 Dec;30(12):2063. Epub 2014 Aug 6 doi: 10.1007/s00381-014-2513-5. PMID: 25096071
Massimino M, Clerici CA
Childs Nerv Syst 2014 Dec;30(12):2065-6. Epub 2014 Jul 31 doi: 10.1007/s00381-014-2511-7. PMID: 25079885
Burzynski SR, Janicki TJ, Burzynski GS, Marszalek A
Childs Nerv Syst 2014 Dec;30(12):2051-61. Epub 2014 Apr 10 doi: 10.1007/s00381-014-2401-z. PMID: 24718705Free PMC Article

Prognosis

Burzynski SR, Burzynski GS, Janicki TJ, Marszalek A
Pediatr Neurosurg 2015;50(2):99-103. Epub 2015 Apr 22 doi: 10.1159/000369907. PMID: 25926271
Di Rocco C
Childs Nerv Syst 2014 Dec;30(12):2063. Epub 2014 Aug 6 doi: 10.1007/s00381-014-2513-5. PMID: 25096071
Massimino M, Clerici CA
Childs Nerv Syst 2014 Dec;30(12):2065-6. Epub 2014 Jul 31 doi: 10.1007/s00381-014-2511-7. PMID: 25079885
Burzynski SR, Janicki TJ, Burzynski GS, Marszalek A
Childs Nerv Syst 2014 Dec;30(12):2051-61. Epub 2014 Apr 10 doi: 10.1007/s00381-014-2401-z. PMID: 24718705Free PMC Article
Burzynski SR, Janicki TJ, Weaver RA, Burzynski B
Integr Cancer Ther 2006 Mar;5(1):40-7. doi: 10.1177/1534735405285380. PMID: 16484713

Clinical prediction guides

Burzynski SR, Janicki TJ, Burzynski GS, Marszalek A
Childs Nerv Syst 2014 Dec;30(12):2051-61. Epub 2014 Apr 10 doi: 10.1007/s00381-014-2401-z. PMID: 24718705Free PMC Article
Burzynski SR, Lewy RI, Weaver RA, Axler ML, Janicki TJ, Jurida GF, Paszkowiak JK, Szymkowski BG, Khan MI, Bestak M
Drugs R D 2003;4(2):91-101. PMID: 12718563
Decker GM
Clin J Oncol Nurs 2000 Sep-Oct;4(5):242-4. PMID: 11111459
Tsuda H, Sata M, Kumabe T, Hara H, Eriguchi N, Sugita Y, Nagamatsu H
Oncol Rep 1998 May-Jun;5(3):597-600. PMID: 9538158
Sugita Y, Tsuda H, Maruiwa H, Hirohata M, Shigemori M, Hara H
Kurume Med J 1995;42(3):133-40. PMID: 7474850

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