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Monoclonal Antibody 3F8

MedGen UID:
79200
Concept ID:
C0280849
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
Synonyms: 3F8; 3F8 Monoclonal Antibody; anti-Ganglioside (GD2) Monoclonal Antibody 3F8; MoAb 3F8
 

Definition

A murine monoclonal antibody directed against the cell-surface, tumor-associated antigen ganglioside GD2. Vaccination with monoclonal antibody 3F8 may stimulate a host cytotoxic immune response against tumors that express ganglioside GD2. (NCI04) [from NCI]

Recent clinical studies

Etiology

Kramer K, Pandit-Taskar N, Humm JL, Zanzonico PB, Haque S, Dunkel IJ, Wolden SL, Donzelli M, Goldman DA, Lewis JS, Lyashchenko SK, Khakoo Y, Carrasquillo JA, Souweidane MM, Greenfield JP, Lyden D, De Braganca KD, Gilheeney SW, Larson SM, Cheung NV
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Sep 22 doi: 10.1002/pbc.26754. PMID: 28940863
Cheung NK, Cheung IY, Kushner BH, Ostrovnaya I, Chamberlain E, Kramer K, Modak S
J Clin Oncol 2012 Sep 10;30(26):3264-70. Epub 2012 Aug 6 doi: 10.1200/JCO.2011.41.3807. PMID: 22869886Free PMC Article
Kushner BH, Kramer K, Modak S, Cheung NK
J Clin Oncol 2011 Mar 20;29(9):1168-74. Epub 2011 Feb 22 doi: 10.1200/JCO.2010.28.3317. PMID: 21343563Free PMC Article
Kushner BH, Cheung IY, Kramer K, Modak S, Cheung NK
Pediatr Blood Cancer 2007 Apr;48(4):430-4. doi: 10.1002/pbc.20765. PMID: 16421906
Cheung NK, Modak S
Clin Cancer Res 2002 May;8(5):1217-23. PMID: 12006541

Diagnosis

Cheung NK, Cheung IY, Kushner BH, Ostrovnaya I, Chamberlain E, Kramer K, Modak S
J Clin Oncol 2012 Sep 10;30(26):3264-70. Epub 2012 Aug 6 doi: 10.1200/JCO.2011.41.3807. PMID: 22869886Free PMC Article
Cheung IY, Lo Piccolo MS, Kushner BH, Kramer K, Cheung NK
J Clin Oncol 2003 Mar 15;21(6):1087-93. doi: 10.1200/JCO.2003.02.055. PMID: 12637475
Cheung NK, Guo HF, Cheung IY
Med Pediatr Oncol 2000 Dec;35(6):635-7. PMID: 11107135
Kushner BH, Cheung NK
Cancer Res 1991 Sep 15;51(18):4865-70. PMID: 1654202
Cheung NK, Lazarus H, Miraldi FD, Abramowsky CR, Kallick S, Saarinen UM, Spitzer T, Strandjord SE, Coccia PF, Berger NA
J Clin Oncol 1987 Sep;5(9):1430-40. doi: 10.1200/JCO.1987.5.9.1430. PMID: 3625258

Therapy

Cheung NK, Cheung IY, Kushner BH, Ostrovnaya I, Chamberlain E, Kramer K, Modak S
J Clin Oncol 2012 Sep 10;30(26):3264-70. Epub 2012 Aug 6 doi: 10.1200/JCO.2011.41.3807. PMID: 22869886Free PMC Article
Kushner BH, Kramer K, Modak S, Cheung NK
J Clin Oncol 2011 Mar 20;29(9):1168-74. Epub 2011 Feb 22 doi: 10.1200/JCO.2010.28.3317. PMID: 21343563Free PMC Article
Kushner BH, Cheung IY, Kramer K, Modak S, Cheung NK
Pediatr Blood Cancer 2007 Apr;48(4):430-4. doi: 10.1002/pbc.20765. PMID: 16421906
Cheung NK, Modak S
Clin Cancer Res 2002 May;8(5):1217-23. PMID: 12006541
Kushner BH, Kramer K, Cheung NK
J Clin Oncol 2001 Nov 15;19(22):4189-94. doi: 10.1200/JCO.2001.19.22.4189. PMID: 11709561

Prognosis

Kramer K, Pandit-Taskar N, Humm JL, Zanzonico PB, Haque S, Dunkel IJ, Wolden SL, Donzelli M, Goldman DA, Lewis JS, Lyashchenko SK, Khakoo Y, Carrasquillo JA, Souweidane MM, Greenfield JP, Lyden D, De Braganca KD, Gilheeney SW, Larson SM, Cheung NV
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Sep 22 doi: 10.1002/pbc.26754. PMID: 28940863
Cheung NK, Cheung IY, Kushner BH, Ostrovnaya I, Chamberlain E, Kramer K, Modak S
J Clin Oncol 2012 Sep 10;30(26):3264-70. Epub 2012 Aug 6 doi: 10.1200/JCO.2011.41.3807. PMID: 22869886Free PMC Article
Kushner BH, Kramer K, Modak S, Cheung NK
J Clin Oncol 2011 Mar 20;29(9):1168-74. Epub 2011 Feb 22 doi: 10.1200/JCO.2010.28.3317. PMID: 21343563Free PMC Article
Cheung NK, Modak S
Clin Cancer Res 2002 May;8(5):1217-23. PMID: 12006541
Cheung NK, Guo HF, Cheung IY
Med Pediatr Oncol 2000 Dec;35(6):635-7. PMID: 11107135

Clinical prediction guides

Dobrenkov K, Ostrovnaya I, Gu J, Cheung IY, Cheung NK
Pediatr Blood Cancer 2016 Oct;63(10):1780-5. Epub 2016 Jun 15 doi: 10.1002/pbc.26097. PMID: 27304202Free PMC Article
Kramer K, Smith M, Souweidane MM
Pediatr Blood Cancer 2014 Sep;61(9):1590-2. Epub 2014 Apr 29 doi: 10.1002/pbc.25080. PMID: 24777835
Grant SC, Kostakoglu L, Kris MG, Yeh SD, Larson SM, Finn RD, Oettgen HF, Cheung NV
Eur J Nucl Med 1996 Feb;23(2):145-9. PMID: 8925848
Patel K, Rossell RJ, Pemberton LF, Cheung NK, Walsh FS, Moore SE, Sugimoto T, Kemshead JT
Br J Cancer 1989 Dec;60(6):861-6. PMID: 2481486Free PMC Article
Cheung NK, Lazarus H, Miraldi FD, Abramowsky CR, Kallick S, Saarinen UM, Spitzer T, Strandjord SE, Coccia PF, Berger NA
J Clin Oncol 1987 Sep;5(9):1430-40. doi: 10.1200/JCO.1987.5.9.1430. PMID: 3625258

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