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Chromosome 14;16 translocation

MedGen UID:
435014
•Concept ID:
CN072186
•
Disease or Syndrome

Professional guidelines

PubMed

BCL2 and miR-15/16: from gene discovery to treatment.
Pekarsky Y, Balatti V, Croce CM
Cell Death Differ 2018 Jan;25(1):21-26. Epub 2017 Oct 6 doi: 10.1038/cdd.2017.159. PMID: 28984869Free PMC Article
Investigative tools for diagnosis and management.
Munshi NC
Hematology Am Soc Hematol Educ Program 2008:298-305. doi: 10.1182/asheducation-2008.1.298. PMID: 19074100
Genetic counseling in Robertsonian translocations der(13;14): frequencies of reproductive outcomes and infertility in 101 pedigrees.
Engels H, Eggermann T, Caliebe A, Jelska A, Schubert R, Schüler HM, Panasiuk B, Zaremba J, Latos-Bieleńska A, Jakubowski L, Zerres KP, Schwanitz G, Midro AT
Am J Med Genet A 2008 Oct 15;146A(20):2611-6. doi: 10.1002/ajmg.a.32500. PMID: 18798317

Recent clinical studies

Etiology

Imaging flow cytometry-based multiplex FISH for three IGH translocations in multiple myeloma.
Tsukamoto T, Kinoshita M, Yamada K, Ito H, Yamaguchi T, Chinen Y, Mizutani S, Fujino T, Kobayashi T, Shimura Y, Inazawa J, Kuroda J
J Hum Genet 2023 Jul;68(7):507-514. Epub 2023 Mar 8 doi: 10.1038/s10038-023-01136-2. PMID: 36882509Free PMC Article
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma.
Kaufman JL, Gasparetto C, Schjesvold FH, Moreau P, Touzeau C, Facon T, Boise LH, Jiang Y, Yang X, Dunbar F, Vishwamitra D, Unger S, Macartney T, Pesko J, Yu Y, Salem AH, Ross JA, Hong WJ, Maciag PC, Pauff JM, Kumar S
Am J Hematol 2021 Apr 1;96(4):418-427. Epub 2021 Jan 19 doi: 10.1002/ajh.26083. PMID: 33368455Free PMC Article
IgH translocation with undefined partners is associated with superior outcome in multiple myeloma patients.
Mao XH, Zhuang JL, Zhao DD, Li XQ, Du X, Hao M, Xu Y, Yan YT, Liu JH, Fan HS, Sui WW, Deng SH, Li CW, Zhao JW, Yi SH, Du CX, Zou DH, Li ZJ, Zhao YZ, Zhan FH, Tai YT, Fang BJ, Song YP, Wang JX, Anderson KC, Qiu LG, An G
Eur J Haematol 2020 Sep;105(3):326-334. Epub 2020 Jun 9 doi: 10.1111/ejh.13440. PMID: 32421883
Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?
Avet-Loiseau H, Malard F, Campion L, Magrangeas F, Sebban C, Lioure B, Decaux O, Lamy T, Legros L, Fuzibet JG, Michallet M, Corront B, Lenain P, Hulin C, Mathiot C, Attal M, Facon T, Harousseau JL, Minvielle S, Moreau P; Intergroupe Francophone du Myélome
Blood 2011 Feb 10;117(6):2009-11. Epub 2010 Oct 20 doi: 10.1182/blood-2010-07-295105. PMID: 20962323
Breast lymphomas: a clinicopathologic review.
Bobrow LG, Richards MA, Happerfield LC, Diss TC, Isaacson PG, Lammie GA, Millis RR
Hum Pathol 1993 Mar;24(3):274-8. doi: 10.1016/0046-8177(93)90037-h. PMID: 8454272

Diagnosis

Imaging flow cytometry-based multiplex FISH for three IGH translocations in multiple myeloma.
Tsukamoto T, Kinoshita M, Yamada K, Ito H, Yamaguchi T, Chinen Y, Mizutani S, Fujino T, Kobayashi T, Shimura Y, Inazawa J, Kuroda J
J Hum Genet 2023 Jul;68(7):507-514. Epub 2023 Mar 8 doi: 10.1038/s10038-023-01136-2. PMID: 36882509Free PMC Article
IgH translocation with undefined partners is associated with superior outcome in multiple myeloma patients.
Mao XH, Zhuang JL, Zhao DD, Li XQ, Du X, Hao M, Xu Y, Yan YT, Liu JH, Fan HS, Sui WW, Deng SH, Li CW, Zhao JW, Yi SH, Du CX, Zou DH, Li ZJ, Zhao YZ, Zhan FH, Tai YT, Fang BJ, Song YP, Wang JX, Anderson KC, Qiu LG, An G
Eur J Haematol 2020 Sep;105(3):326-334. Epub 2020 Jun 9 doi: 10.1111/ejh.13440. PMID: 32421883
Newly diagnosed multiple myeloma patients carrying monoallelic deletion of the whole locus of immunoglobulin heavy chain gene have a better prognosis compared to those with t(4;14) and t(14;16).
Duek A, Trakhtenbrot L, Amariglio N, Benyamini N, Zilbershats I, Ganzel C, Shevetz O, Leiba R, Rozic G, Nagler A, Leiba M
Genes Chromosomes Cancer 2019 Aug;58(8):516-520. Epub 2019 Feb 6 doi: 10.1002/gcc.22738. PMID: 30675954
MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma.
Qiang YW, Ye S, Chen Y, Buros AF, Edmonson R, van Rhee F, Barlogie B, Epstein J, Morgan GJ, Davies FE
Blood 2016 Dec 22;128(25):2919-2930. Epub 2016 Oct 28 doi: 10.1182/blood-2016-03-706077. PMID: 27793878Free PMC Article
Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?
Avet-Loiseau H, Malard F, Campion L, Magrangeas F, Sebban C, Lioure B, Decaux O, Lamy T, Legros L, Fuzibet JG, Michallet M, Corront B, Lenain P, Hulin C, Mathiot C, Attal M, Facon T, Harousseau JL, Minvielle S, Moreau P; Intergroupe Francophone du Myélome
Blood 2011 Feb 10;117(6):2009-11. Epub 2010 Oct 20 doi: 10.1182/blood-2010-07-295105. PMID: 20962323

Therapy

Hematological and Genetic Markers in the Rational Approach to Patients With HCV Sustained Virological Response With or Without Persisting Cryoglobulinemic Vasculitis.
Gragnani L, Lorini S, Marri S, Basile U, Santarlasci V, Monti M, Madia F, Petraccia L, Stasi C, Marello N, Napodano C, Annunziato F, Zignego AL
Hepatology 2021 Sep;74(3):1164-1173. Epub 2021 May 26 doi: 10.1002/hep.31804. PMID: 33721342Free PMC Article
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma.
Kaufman JL, Gasparetto C, Schjesvold FH, Moreau P, Touzeau C, Facon T, Boise LH, Jiang Y, Yang X, Dunbar F, Vishwamitra D, Unger S, Macartney T, Pesko J, Yu Y, Salem AH, Ross JA, Hong WJ, Maciag PC, Pauff JM, Kumar S
Am J Hematol 2021 Apr 1;96(4):418-427. Epub 2021 Jan 19 doi: 10.1002/ajh.26083. PMID: 33368455Free PMC Article
IgH translocation with undefined partners is associated with superior outcome in multiple myeloma patients.
Mao XH, Zhuang JL, Zhao DD, Li XQ, Du X, Hao M, Xu Y, Yan YT, Liu JH, Fan HS, Sui WW, Deng SH, Li CW, Zhao JW, Yi SH, Du CX, Zou DH, Li ZJ, Zhao YZ, Zhan FH, Tai YT, Fang BJ, Song YP, Wang JX, Anderson KC, Qiu LG, An G
Eur J Haematol 2020 Sep;105(3):326-334. Epub 2020 Jun 9 doi: 10.1111/ejh.13440. PMID: 32421883
BCL2 and miR-15/16: from gene discovery to treatment.
Pekarsky Y, Balatti V, Croce CM
Cell Death Differ 2018 Jan;25(1):21-26. Epub 2017 Oct 6 doi: 10.1038/cdd.2017.159. PMID: 28984869Free PMC Article
Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?
Avet-Loiseau H, Malard F, Campion L, Magrangeas F, Sebban C, Lioure B, Decaux O, Lamy T, Legros L, Fuzibet JG, Michallet M, Corront B, Lenain P, Hulin C, Mathiot C, Attal M, Facon T, Harousseau JL, Minvielle S, Moreau P; Intergroupe Francophone du Myélome
Blood 2011 Feb 10;117(6):2009-11. Epub 2010 Oct 20 doi: 10.1182/blood-2010-07-295105. PMID: 20962323

Prognosis

Imaging flow cytometry-based multiplex FISH for three IGH translocations in multiple myeloma.
Tsukamoto T, Kinoshita M, Yamada K, Ito H, Yamaguchi T, Chinen Y, Mizutani S, Fujino T, Kobayashi T, Shimura Y, Inazawa J, Kuroda J
J Hum Genet 2023 Jul;68(7):507-514. Epub 2023 Mar 8 doi: 10.1038/s10038-023-01136-2. PMID: 36882509Free PMC Article
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma.
Kaufman JL, Gasparetto C, Schjesvold FH, Moreau P, Touzeau C, Facon T, Boise LH, Jiang Y, Yang X, Dunbar F, Vishwamitra D, Unger S, Macartney T, Pesko J, Yu Y, Salem AH, Ross JA, Hong WJ, Maciag PC, Pauff JM, Kumar S
Am J Hematol 2021 Apr 1;96(4):418-427. Epub 2021 Jan 19 doi: 10.1002/ajh.26083. PMID: 33368455Free PMC Article
Newly diagnosed multiple myeloma patients carrying monoallelic deletion of the whole locus of immunoglobulin heavy chain gene have a better prognosis compared to those with t(4;14) and t(14;16).
Duek A, Trakhtenbrot L, Amariglio N, Benyamini N, Zilbershats I, Ganzel C, Shevetz O, Leiba R, Rozic G, Nagler A, Leiba M
Genes Chromosomes Cancer 2019 Aug;58(8):516-520. Epub 2019 Feb 6 doi: 10.1002/gcc.22738. PMID: 30675954
Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?
Avet-Loiseau H, Malard F, Campion L, Magrangeas F, Sebban C, Lioure B, Decaux O, Lamy T, Legros L, Fuzibet JG, Michallet M, Corront B, Lenain P, Hulin C, Mathiot C, Attal M, Facon T, Harousseau JL, Minvielle S, Moreau P; Intergroupe Francophone du Myélome
Blood 2011 Feb 10;117(6):2009-11. Epub 2010 Oct 20 doi: 10.1182/blood-2010-07-295105. PMID: 20962323
Breast lymphomas: a clinicopathologic review.
Bobrow LG, Richards MA, Happerfield LC, Diss TC, Isaacson PG, Lammie GA, Millis RR
Hum Pathol 1993 Mar;24(3):274-8. doi: 10.1016/0046-8177(93)90037-h. PMID: 8454272

Clinical prediction guides

IgH translocation with undefined partners is associated with superior outcome in multiple myeloma patients.
Mao XH, Zhuang JL, Zhao DD, Li XQ, Du X, Hao M, Xu Y, Yan YT, Liu JH, Fan HS, Sui WW, Deng SH, Li CW, Zhao JW, Yi SH, Du CX, Zou DH, Li ZJ, Zhao YZ, Zhan FH, Tai YT, Fang BJ, Song YP, Wang JX, Anderson KC, Qiu LG, An G
Eur J Haematol 2020 Sep;105(3):326-334. Epub 2020 Jun 9 doi: 10.1111/ejh.13440. PMID: 32421883
Clinical Implications of t(11;14) in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation.
Takamatsu H, Yamashita T, Kurahashi S, Saitoh T, Kondo T, Maeda T, Nakazawa H, Murata M, Narita T, Kuroda J, Hashimoto H, Kawamura K, Miyamoto T, Honda S, Ichinohe T, Atsuta Y, Sunami K
Biol Blood Marrow Transplant 2019 Mar;25(3):474-479. Epub 2018 Nov 10 doi: 10.1016/j.bbmt.2018.11.003. PMID: 30423479
Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?
Avet-Loiseau H, Malard F, Campion L, Magrangeas F, Sebban C, Lioure B, Decaux O, Lamy T, Legros L, Fuzibet JG, Michallet M, Corront B, Lenain P, Hulin C, Mathiot C, Attal M, Facon T, Harousseau JL, Minvielle S, Moreau P; Intergroupe Francophone du Myélome
Blood 2011 Feb 10;117(6):2009-11. Epub 2010 Oct 20 doi: 10.1182/blood-2010-07-295105. PMID: 20962323
Translocation t(11;14) and survival of patients with light chain (AL) amyloidosis.
Bryce AH, Ketterling RP, Gertz MA, Lacy M, Knudson RA, Zeldenrust S, Kumar S, Hayman S, Buadi F, Kyle RA, Greipp PR, Lust JA, Russell S, Rajkumar SV, Fonseca R, Dispenzieri A
Haematologica 2009 Mar;94(3):380-6. Epub 2009 Feb 11 doi: 10.3324/haematol.13369. PMID: 19211640Free PMC Article
Cytogenetic and molecular studies of t(14;18) and t(14;19) in nodal and extranodal B-cell lymphoma.
Clark HM, Jones DB, Wright DH
J Pathol 1992 Feb;166(2):129-37. doi: 10.1002/path.1711660208. PMID: 1560313

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