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Items: 1 to 20 of 25

1.

Trypsin

A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4. [from MeSH]

MedGen UID:
21715
Concept ID:
C0041236
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
2.

Serine

A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04) [from NCI]

MedGen UID:
11382
Concept ID:
C0036720
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
3.

Serpin

A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known. [from MeSH]

MedGen UID:
48634
Concept ID:
C0036764
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
4.

Malignancies

MedGen UID:
924235
Concept ID:
C4282132
Neoplastic Process
5.

Serpin Superfamily

MedGen UID:
20714
Concept ID:
C0036763
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
6.

Plasminogen activator

A family of serine proteases that catalyze the proteolytic conversion of plasminogen to plasmin. [from NCI]

MedGen UID:
18508
Concept ID:
C0032144
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
7.

Thrombin

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN. [from MeSH]

MedGen UID:
11796
Concept ID:
C0040018
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
8.

Plasminogen

Plasminogen (810 aa, ~91 kDa) is encoded by the human PLG gene. This protein is involved in fibrinolysis, platelet activation and tissue remodeling. [from NCI]

MedGen UID:
10793
Concept ID:
C0032140
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
9.

Chymotrypsin

A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side. [from MeSH]

MedGen UID:
971
Concept ID:
C0008742
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
10.

Proteinase inhibitor

MedGen UID:
743840
Concept ID:
C1961133
Organic Chemical; Pharmacologic Substance
11.

Unable

A response indicating that an individual cannot do something. [from NCI]

MedGen UID:
721425
Concept ID:
C1299582
Finding
12.

ph+++

MedGen UID:
623899
Concept ID:
C0450409
Finding
13.

ph++

MedGen UID:
623898
Concept ID:
C0450408
Finding
14.

ph+

MedGen UID:
623897
Concept ID:
C0450407
Finding
15.

Bovine thrombin

MedGen UID:
452981
Concept ID:
C1337342
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
16.

Neoplasm of the breast

Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both women and men, the most common form of breast cancer begins in cells lining the milk ducts (ductal cancer). In women, cancer can also develop in the glands that produce milk (lobular cancer). Most men have little or no lobular tissue, so lobular cancer in men is very rare.In its early stages, breast cancer usually does not cause pain and may exhibit no noticeable symptoms. As the cancer progresses, signs and symptoms can include a lump or thickening in or near the breast; a change in the size or shape of the breast; nipple discharge, tenderness, or retraction (turning inward); and skin irritation, dimpling, or scaliness. However, these changes can occur as part of many different conditions. Having one or more of these symptoms does not mean that a person definitely has breast cancer.In some cases, cancerous tumors can invade surrounding tissue and spread to other parts of the body. If breast cancer spreads, cancerous cells most often appear in the bones, liver, lungs, or brain. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers.A small percentage of all breast cancers cluster in families. These cancers are described as hereditary and are associated with inherited gene mutations. Hereditary breast cancers tend to develop earlier in life than noninherited (sporadic) cases, and new (primary) tumors are more likely to develop in both breasts. [from GTR]

MedGen UID:
264172
Concept ID:
C1458155
Neoplastic Process
17.

Urokinase

A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES. [from MeSH]

MedGen UID:
21790
Concept ID:
C0042071
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
18.

Serine proteinase inhibitor

A protein that plays a role in the inhibition of serine proteinases. [from NCI]

MedGen UID:
20708
Concept ID:
C0036733
Biologically Active Substance; Pharmacologic Substance
19.

Peptide hydrolase inhibitor

Any substance that inhibits a protease, an enzyme that breaks peptide bonds. Proteases are required for many cell processes and inhibition of proteases can inhibit viral replication, inflammatory responses, proliferation, and tumor growth. [from NCI]

MedGen UID:
18701
Concept ID:
C0033607
Pharmacologic Substance
20.

Enzyme inhibitor

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from MeSH]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
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