Format

Send to:

Choose Destination

Links from PubMed

Homodimerization

MedGen UID:
307573
Concept ID:
C1512485
Molecular Function
 

Definition

Homodimerization involves a biophysical interaction between two identical biological molecules or subunits, such as proteins. The interaction is often mediated by a biophysical interaction between one or more specific domains within the subunits and, typically, significantly influences the function of the subunits. [from NCI]

Recent clinical studies

Etiology

Xu X, Xu X, Liu P, Zhu ZY, Chen J, Fu HA, Chen LL, Hu LH, Shen X
J Biol Chem 2015 Aug 7;290(32):19888-99. Epub 2015 Jun 22 doi: 10.1074/jbc.M114.630475. PMID: 26100621Free PMC Article
van Galen J, Olrichs NK, Schouten A, Serrano RL, Nolte-'t Hoen EN, Eerland R, Kaloyanova D, Gros P, Helms JB
Biochim Biophys Acta 2012 Sep;1818(9):2175-83. Epub 2012 Apr 26 doi: 10.1016/j.bbamem.2012.04.016. PMID: 22560898
Kim YS, Park ZY, Kim SY, Jeong E, Lee JY
Chem Biol Interact 2009 Nov 10;182(1):59-66. Epub 2009 Jul 21 doi: 10.1016/j.cbi.2009.07.009. PMID: 19627980
Iyer AK, Zhang YH, McCabe ER
Mol Genet Metab 2007 Sep-Oct;92(1-2):151-9. Epub 2007 Aug 7 doi: 10.1016/j.ymgme.2007.06.009. PMID: 17686645Free PMC Article
Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM
Hum Mol Genet 2006 Dec 1;15(23):3411-9. Epub 2006 Oct 17 doi: 10.1093/hmg/ddl417. PMID: 17047026

Diagnosis

Shalaby S, Mitsuhashi H, Matsuda C, Minami N, Noguchi S, Nonaka I, Nishino I, Hayashi YK
J Neuropathol Exp Neurol 2009 Jun;68(6):701-7. doi: 10.1097/NEN.0b013e3181a7f703. PMID: 19458539
Shi Y, Huang W, Tan Y, Jin X, Dua R, Penuel E, Mukherjee A, Sperinde J, Pannu H, Chenna A, DeFazio-Eli L, Pidaparthi S, Badal Y, Wallweber G, Chen L, Williams S, Tahir H, Larson J, Goodman L, Whitcomb J, Petropoulos C, Winslow J
Diagn Mol Pathol 2009 Mar;18(1):11-21. doi: 10.1097/PDM.0b013e31818cbdb2. PMID: 19214113
Zhao H, Sohail A, Sun Q, Shi Q, Kim S, Mobashery S, Fridman R
J Biol Chem 2008 Dec 12;283(50):35023-32. Epub 2008 Oct 20 doi: 10.1074/jbc.M806553200. PMID: 18936094Free PMC Article
Iyer AK, Zhang YH, McCabe ER
Mol Genet Metab 2007 Sep-Oct;92(1-2):151-9. Epub 2007 Aug 7 doi: 10.1016/j.ymgme.2007.06.009. PMID: 17686645Free PMC Article
Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM
Hum Mol Genet 2006 Dec 1;15(23):3411-9. Epub 2006 Oct 17 doi: 10.1093/hmg/ddl417. PMID: 17047026

Therapy

Ohnishi T, Sakamoto K, Asami-Odaka A, Nakamura K, Shimizu A, Ito T, Asami T, Ohtaki T, Inooka H
Biochem Biophys Res Commun 2017 Jan 29;483(1):101-106. Epub 2016 Dec 31 doi: 10.1016/j.bbrc.2016.12.186. PMID: 28043792
Li YT, Qian XJ, Yu Y, Li ZH, Wu RY, Ji J, Jiao L, Li X, Kong PF, Chen WD, Feng GK, Deng R, Zhu XF
Oncotarget 2015 Jul 10;6(19):17491-500. doi: 10.18632/oncotarget.3959. PMID: 26036637Free PMC Article
Loiarro M, Capolunghi F, Fantò N, Gallo G, Campo S, Arseni B, Carsetti R, Carminati P, De Santis R, Ruggiero V, Sette C
J Leukoc Biol 2007 Oct;82(4):801-10. Epub 2007 Jun 4 doi: 10.1189/jlb.1206746. PMID: 17548806
Lis M, Blumenthal K
Biochem Biophys Res Commun 2006 Jan 6;339(1):321-4. Epub 2005 Nov 15 doi: 10.1016/j.bbrc.2005.11.022. PMID: 16297866
Ghetie MA, Podar EM, Ilgen A, Gordon BE, Uhr JW, Vitetta ES
Proc Natl Acad Sci U S A 1997 Jul 8;94(14):7509-14. PMID: 9207122Free PMC Article

Prognosis

Khadria AS, Mueller BK, Stefely JA, Tan CH, Pagliarini DJ, Senes A
J Am Chem Soc 2014 Oct 8;136(40):14068-77. Epub 2014 Sep 24 doi: 10.1021/ja505017f. PMID: 25216398Free PMC Article
van Galen J, Olrichs NK, Schouten A, Serrano RL, Nolte-'t Hoen EN, Eerland R, Kaloyanova D, Gros P, Helms JB
Biochim Biophys Acta 2012 Sep;1818(9):2175-83. Epub 2012 Apr 26 doi: 10.1016/j.bbamem.2012.04.016. PMID: 22560898
Masters TA, Calleja V, Armoogum DA, Marsh RJ, Applebee CJ, Laguerre M, Bain AJ, Larijani B
Sci Signal 2010 Oct 26;3(145):ra78. doi: 10.1126/scisignal.2000738. PMID: 20978239
Ravulapalli R, Campbell RL, Gauthier SY, Dhe-Paganon S, Davies PL
FEBS J 2009 Feb;276(4):973-82. doi: 10.1111/j.1742-4658.2008.06833.x. PMID: 19215300
Shi Y, Huang W, Tan Y, Jin X, Dua R, Penuel E, Mukherjee A, Sperinde J, Pannu H, Chenna A, DeFazio-Eli L, Pidaparthi S, Badal Y, Wallweber G, Chen L, Williams S, Tahir H, Larson J, Goodman L, Whitcomb J, Petropoulos C, Winslow J
Diagn Mol Pathol 2009 Mar;18(1):11-21. doi: 10.1097/PDM.0b013e31818cbdb2. PMID: 19214113

Clinical prediction guides

Oasa S, Sasaki A, Yamamoto J, Mikuni S, Kinjo M
FEBS Lett 2015 Aug 4;589(17):2171-8. Epub 2015 Jul 13 doi: 10.1016/j.febslet.2015.07.003. PMID: 26183204
Mateo M, Navaratnarajah CK, Willenbring RC, Maroun JW, Iankov I, Lopez M, Sinn PL, Cattaneo R
J Virol 2014 Dec;88(24):14161-71. Epub 2014 Oct 1 doi: 10.1128/JVI.02379-14. PMID: 25275122Free PMC Article
Song Y, Hustedt EJ, Brandon S, Sanders CR
Biochemistry 2013 Jul 30;52(30):5051-64. Epub 2013 Jul 18 doi: 10.1021/bi400735x. PMID: 23865807Free PMC Article
Béland M, Motard J, Barbarin A, Roucou X
J Neurosci 2012 Sep 19;32(38):13255-63. doi: 10.1523/JNEUROSCI.2236-12.2012. PMID: 22993441
Spurr IB, Birts CN, Cuda F, Benkovic SJ, Blaydes JP, Tavassoli A
Chembiochem 2012 Jul 23;13(11):1628-34. Epub 2012 Jul 4 doi: 10.1002/cbic.201200279. PMID: 22764122Free PMC Article

Recent systematic reviews

Supplemental Content

Table of contents

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    Support Center