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Choriocarcinoma

MedGen UID:
40278
Concept ID:
C0008497
Neoplastic Process
Synonyms: Choriocarcinomas
SNOMED CT: [M]Chorioepithelioma (44769000); [M]Choriocarcinoma (44769000); Choriocarcinoma, no ICD-O subtype (44769000); Choriocarcinoma (188188009); Chorioepithelioma (188188009); Chorionepithelioma (188188009); Choriocarcinoma, no International Classification of Diseases for Oncology subtype (44769000); Choriocarcinoma (44769000); Chorionepithelioma (44769000); Chorioepithelioma (44769000); Syncytioma (44769000)
 
HPO: HP:0100768

Definition

A malignant, trophoblastic and aggressive cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs and belongs to the far end of the spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumors. [from HPO]

Recent clinical studies

Etiology

Popadiuk C, Power P
J Reprod Med 2016 May-Jun;61(5-6):215-8. PMID: 27424361
Brătilă E, Ionescu CA, Vlădescu CT, Cîrstoiu MM, Berceanu C
Rom J Morphol Embryol 2015;56(1):267-71. PMID: 25826515
Taylor F, Short D, Winter MC, Tidy J, Savage PM, Sarwar N, Hancock BW, Seckl MJ, Coleman RE
Gynecol Oncol 2015 Feb;136(2):258-63. Epub 2014 Dec 24 doi: 10.1016/j.ygyno.2014.12.024. PMID: 25542400
Ryu N, Ogawa M, Matsui H, Usui H, Shozu M
Int J Gynecol Cancer 2015 Jun;25(5):926-30. doi: 10.1097/IGC.0000000000000184. PMID: 24987912
Diver E, May T, Vargas R, Bernstein M, Goldstein D, Berkowitz R
Gynecol Oncol 2013 Sep;130(3):483-6. Epub 2013 Jun 15 doi: 10.1016/j.ygyno.2013.06.014. PMID: 23777658

Diagnosis

Yu P, Diao W, Jiang X
Medicine (Baltimore) 2016 May;95(21):e3505. doi: 10.1097/MD.0000000000003505. PMID: 27227917Free PMC Article
Cox JL, Talmon GA, Koepsell SA
Dis Markers 2016;2016:5236482. Epub 2016 Mar 13 doi: 10.1155/2016/5236482. PMID: 27034532Free PMC Article
Cho EB, Byun JM, Jeong DH, Yoon HK, Kim YN, Sung MS, Lee KB, Kim KT
Tumori 2016 Nov 11;102(Suppl. 2) doi: 10.5301/tj.5000379. PMID: 26166218
Taylor F, Short D, Winter MC, Tidy J, Savage PM, Sarwar N, Hancock BW, Seckl MJ, Coleman RE
Gynecol Oncol 2015 Feb;136(2):258-63. Epub 2014 Dec 24 doi: 10.1016/j.ygyno.2014.12.024. PMID: 25542400
Kaabia O, Meddeb S, Rhim MS, Bibi M, Khairi H
Pan Afr Med J 2014;19:176. Epub 2014 Oct 20 doi: 10.11604/pamj.2014.19.176.5403. PMID: 25815097Free PMC Article

Therapy

Popadiuk C, Power P
J Reprod Med 2016 May-Jun;61(5-6):215-8. PMID: 27424361
Yu P, Diao W, Jiang X
Medicine (Baltimore) 2016 May;95(21):e3505. doi: 10.1097/MD.0000000000003505. PMID: 27227917Free PMC Article
Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112
Taylor F, Short D, Winter MC, Tidy J, Savage PM, Sarwar N, Hancock BW, Seckl MJ, Coleman RE
Gynecol Oncol 2015 Feb;136(2):258-63. Epub 2014 Dec 24 doi: 10.1016/j.ygyno.2014.12.024. PMID: 25542400
Ryu N, Ogawa M, Matsui H, Usui H, Shozu M
Int J Gynecol Cancer 2015 Jun;25(5):926-30. doi: 10.1097/IGC.0000000000000184. PMID: 24987912

Prognosis

Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112
Taylor F, Short D, Winter MC, Tidy J, Savage PM, Sarwar N, Hancock BW, Seckl MJ, Coleman RE
Gynecol Oncol 2015 Feb;136(2):258-63. Epub 2014 Dec 24 doi: 10.1016/j.ygyno.2014.12.024. PMID: 25542400
Ryu N, Ogawa M, Matsui H, Usui H, Shozu M
Int J Gynecol Cancer 2015 Jun;25(5):926-30. doi: 10.1097/IGC.0000000000000184. PMID: 24987912
Kaabia O, Meddeb S, Rhim MS, Bibi M, Khairi H
Pan Afr Med J 2014;19:176. Epub 2014 Oct 20 doi: 10.11604/pamj.2014.19.176.5403. PMID: 25815097Free PMC Article
Wang J, Wang R, Zhao J
J Clin Neurosci 2013 Sep;20(9):1324-6. Epub 2013 Jul 5 doi: 10.1016/j.jocn.2012.09.045. PMID: 23835464

Clinical prediction guides

Popadiuk C, Power P
J Reprod Med 2016 May-Jun;61(5-6):215-8. PMID: 27424361
Cox JL, Talmon GA, Koepsell SA
Dis Markers 2016;2016:5236482. Epub 2016 Mar 13 doi: 10.1155/2016/5236482. PMID: 27034532Free PMC Article
Shen Y, Yang J, Zhao J, Xiao C, Xu C, Xiang Y
Exp Cell Res 2015 Jun 10;334(2):207-18. Epub 2015 Apr 24 doi: 10.1016/j.yexcr.2015.04.010. PMID: 25912909
Taylor F, Short D, Winter MC, Tidy J, Savage PM, Sarwar N, Hancock BW, Seckl MJ, Coleman RE
Gynecol Oncol 2015 Feb;136(2):258-63. Epub 2014 Dec 24 doi: 10.1016/j.ygyno.2014.12.024. PMID: 25542400
Kaabia O, Meddeb S, Rhim MS, Bibi M, Khairi H
Pan Afr Med J 2014;19:176. Epub 2014 Oct 20 doi: 10.11604/pamj.2014.19.176.5403. PMID: 25815097Free PMC Article

Recent systematic reviews

Bolze PA, Attia J, Massardier J, Seckl MJ, Massuger L, van Trommel N, Niemann I, Hajri T, Schott AM, Golfier F; EOTTD group.
Eur J Cancer 2015 Sep;51(13):1725-31. Epub 2015 Jun 16 doi: 10.1016/j.ejca.2015.05.026. PMID: 26092638
Zheng J, Zhang J
Clin Neurol Neurosurg 2015 Jan;128:107-11. Epub 2014 Nov 22 doi: 10.1016/j.clineuro.2014.11.010. PMID: 25484302
Seckl MJ, Sebire NJ, Fisher RA, Golfier F, Massuger L, Sessa C; ESMO Guidelines Working Group.
Ann Oncol 2013 Oct;24 Suppl 6:vi39-50. Epub 2013 Sep 1 doi: 10.1093/annonc/mdt345. PMID: 23999759
Foulmann K, Guastalla JP, Caminet N, Trillet-Lenoir V, Raudrant D, Golfier F, Schott AM
Gynecol Oncol 2006 Jul;102(1):103-10. Epub 2006 Apr 19 doi: 10.1016/j.ygyno.2006.02.038. PMID: 16624388
Heifetz SA, Czaja J
Pediatr Pathol 1992 Jul-Aug;12(4):601-11. PMID: 1409158

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