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Items: 9

1.

imipramine

A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04) [from NCI]

MedGen UID:
43829
Concept ID:
C0020934
Organic Chemical; Pharmacologic Substance
2.

Phenelzine

One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC. [from MeSH]

MedGen UID:
18407
Concept ID:
C0031392
Organic Chemical; Pharmacologic Substance
3.

Depression

A melancholy feeling of sadness and despair. [from NCI]

MedGen UID:
8325
Concept ID:
C0011570
Mental or Behavioral Dysfunction
4.

Depression

An emotional state characterized by feelings of sadness, emptiness, and/or tearfulness. [from NCI]

MedGen UID:
137999
Concept ID:
C0344315
Finding
5.

Depression

A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure. [from HPO]

MedGen UID:
4229
Concept ID:
C0011581
Mental or Behavioral Dysfunction
6.

Nardelzine

MedGen UID:
288850
Concept ID:
C1563961
Organic Chemical; Pharmacologic Substance
7.

Nardil

MedGen UID:
147259
Concept ID:
C0701388
Organic Chemical; Pharmacologic Substance
8.

Imipramine hydrochloride

The hydrochloride salt form of imipramine, a synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04) [from NCI]

MedGen UID:
154414
Concept ID:
C0589978
Organic Chemical; Pharmacologic Substance
9.

Phenelzine sulfate

A hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects. [from NCI]

MedGen UID:
45852
Concept ID:
C0031393
Organic Chemical; Pharmacologic Substance
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