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Items: 13

1.

Flunarizine

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. [from MeSH]

MedGen UID:
42045
Concept ID:
C0016295
Organic Chemical; Pharmacologic Substance
2.

Migraine

Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms. [from HPO]

MedGen UID:
505085
Concept ID:
CN001878
Finding
3.

Migraine

Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985). One locus for migraine with or without aura (MGR1) has been identified on chromosome 4q24. Other loci for migraine have been identified on 6p21.1-p12.2 (MGR3; 607498), 14q21.2-q22.3 (MGR4; 607501), 19p13 (MGR5; 607508), 1q31 (MGR6; 607516), 15q11-q13 (MGR7; 609179), 5q21 (with or without aura, MGR8, 609570; with aura, MGR9, 609670), 17p13 (MGR10; 610208), 18q12 (MGR11; 610209), 10q22-q23 (MGR12; 611706), and the X chromosome (MGR2; 300125). Mutation in the KCNK18 gene (613655) on chromosome 10q25 causes migraine with aura (MGR13; 613656). A subtype of autosomal dominant migraine with aura (MA), familial hemiplegic migraine (FHM; see 141500), is caused by mutation in the CACNA1A gene (601011) on chromosome 19p13 (FHM1; 141500), by mutation in the ATP1A2 gene (182340) on chromosome 1q21 (FHM2; 602481), or by mutation in the SCN1A gene (182389) on chromosome 2q24 (FHM3; 609634). Another locus for FHM has been mapped to chromosome 1q31 (FHM4; see 607516). There is evidence that a polymorphism in the estrogen receptor gene (ESR1; 133430.0005) and a polymorphism in the TNF gene (191160.0004) may confer susceptibility to migraine. A polymorphism in the endothelin receptor type A gene (EDNRA; 131243.0001) may confer resistance to migraine. [from OMIM]

MedGen UID:
57451
Concept ID:
C0149931
Disease or Syndrome
4.

Cinnipirine

MedGen UID:
289038
Concept ID:
C1564772
Organic Chemical; Pharmacologic Substance
5.

Cisaken

MedGen UID:
289037
Concept ID:
C1564771
Organic Chemical; Pharmacologic Substance
6.

Cinna

MedGen UID:
201446
Concept ID:
C1000982
Organic Chemical; Pharmacologic Substance
7.

R-516

MedGen UID:
196085
Concept ID:
C0701046
Organic Chemical; Pharmacologic Substance
8.

Cinnarizine, Dihydrochloride

MedGen UID:
168376
Concept ID:
C0887757
Organic Chemical; Pharmacologic Substance
9.

R-14950

MedGen UID:
164088
Concept ID:
C0877820
Organic Chemical; Pharmacologic Substance
10.

Stugeron

MedGen UID:
152029
Concept ID:
C0699313
Organic Chemical; Pharmacologic Substance
11.

Dimitronal

MedGen UID:
148477
Concept ID:
C0699312
Organic Chemical; Pharmacologic Substance
12.

Cinnarizine

A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS. [from MeSH]

MedGen UID:
40315
Concept ID:
C0008803
Organic Chemical; Pharmacologic Substance
13.

Sibelium

MedGen UID:
20744
Concept ID:
C0037044
Organic Chemical; Pharmacologic Substance
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