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Transformation

MedGen UID:
266929
Concept ID:
C1510411
Pathologic Function
Synonyms: Cell Transformation; Cellular Transformation; Transformed; Transforming
 

Definition

The conversion of a cell from a normal phenotype, which undergoes a limited number of mitotic divisions, into an aberrant phenotype that is immortal and divides indefinitely. Transformed cells no longer retain cell-cycle checkpoints and may ultimately become malignant cancer cells via additional genetic mutations, or damaging environmental events. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransformation

Recent clinical studies

Etiology

Alonso-Álvarez S, Magnano L, Alcoceba M, Andrade-Campos M, Espinosa-Lara N, Rodríguez G, Mercadal S, Carro I, Sancho JM, Moreno M, Salar A, García-Pallarols F, Arranz R, Cannata J, Terol MJ, Teruel AI, Rodríguez A, Jiménez-Ubieto A, González de Villambrosia S, Bello JL, López L, Monsalvo S, Novelli S, de Cabo E, Infante MS, Pardal E, García-Álvarez M, Delgado J, González M, Martín A, López-Guillermo A, Caballero MD
Br J Haematol 2017 Sep;178(5):699-708. Epub 2017 Aug 7 doi: 10.1111/bjh.14831. PMID: 28782811
Mendez M, Torrente M, Provencio M
Expert Rev Hematol 2017 Jun;10(6):515-524. Epub 2017 May 16 doi: 10.1080/17474086.2017.1326812. PMID: 28480766
Celis AM, Vos AM, Triana S, Medina CA, Escobar N, Restrepo S, Wösten HA, de Cock H
J Microbiol Methods 2017 Mar;134:1-6. Epub 2017 Jan 5 doi: 10.1016/j.mimet.2017.01.001. PMID: 28064034
Labarrere CA, DiCarlo HL, Bammerlin E, Hardin JW, Kim YM, Chaemsaithong P, Haas DM, Kassab GS, Romero R
Am J Obstet Gynecol 2017 Mar;216(3):287.e1-287.e16. Epub 2016 Dec 27 doi: 10.1016/j.ajog.2016.12.029. PMID: 28034657
Ho AL, Koch MJ, Tanaka S, Eichler AF, Batchelor TT, Tanboon J, Louis DN, Cahill DP, Chi AS, Curry WT Jr
J Clin Neurosci 2016 Sep;31:99-105. Epub 2016 Jun 6 doi: 10.1016/j.jocn.2016.02.019. PMID: 27279154

Diagnosis

Alonso-Álvarez S, Magnano L, Alcoceba M, Andrade-Campos M, Espinosa-Lara N, Rodríguez G, Mercadal S, Carro I, Sancho JM, Moreno M, Salar A, García-Pallarols F, Arranz R, Cannata J, Terol MJ, Teruel AI, Rodríguez A, Jiménez-Ubieto A, González de Villambrosia S, Bello JL, López L, Monsalvo S, Novelli S, de Cabo E, Infante MS, Pardal E, García-Álvarez M, Delgado J, González M, Martín A, López-Guillermo A, Caballero MD
Br J Haematol 2017 Sep;178(5):699-708. Epub 2017 Aug 7 doi: 10.1111/bjh.14831. PMID: 28782811
Kridel R, Sehn LH, Gascoyne RD
Blood 2017 Jul 20;130(3):258-266. Epub 2017 Apr 13 doi: 10.1182/blood-2017-03-691345. PMID: 28408460
Labarrere CA, DiCarlo HL, Bammerlin E, Hardin JW, Kim YM, Chaemsaithong P, Haas DM, Kassab GS, Romero R
Am J Obstet Gynecol 2017 Mar;216(3):287.e1-287.e16. Epub 2016 Dec 27 doi: 10.1016/j.ajog.2016.12.029. PMID: 28034657
Pikis S, Margolin E
J Clin Neurosci 2016 Nov;33:59-62. Epub 2016 Aug 9 doi: 10.1016/j.jocn.2016.04.008. PMID: 27519146
Ho AL, Koch MJ, Tanaka S, Eichler AF, Batchelor TT, Tanboon J, Louis DN, Cahill DP, Chi AS, Curry WT Jr
J Clin Neurosci 2016 Sep;31:99-105. Epub 2016 Jun 6 doi: 10.1016/j.jocn.2016.02.019. PMID: 27279154

Therapy

Alonso-Álvarez S, Magnano L, Alcoceba M, Andrade-Campos M, Espinosa-Lara N, Rodríguez G, Mercadal S, Carro I, Sancho JM, Moreno M, Salar A, García-Pallarols F, Arranz R, Cannata J, Terol MJ, Teruel AI, Rodríguez A, Jiménez-Ubieto A, González de Villambrosia S, Bello JL, López L, Monsalvo S, Novelli S, de Cabo E, Infante MS, Pardal E, García-Álvarez M, Delgado J, González M, Martín A, López-Guillermo A, Caballero MD
Br J Haematol 2017 Sep;178(5):699-708. Epub 2017 Aug 7 doi: 10.1111/bjh.14831. PMID: 28782811
Kridel R, Sehn LH, Gascoyne RD
Blood 2017 Jul 20;130(3):258-266. Epub 2017 Apr 13 doi: 10.1182/blood-2017-03-691345. PMID: 28408460
Blaker YN, Spetalen S, Brodtkorb M, Lingjaerde OC, Beiske K, Østenstad B, Sander B, Wahlin BE, Melen CM, Myklebust JH, Holte H, Delabie J, Smeland EB
Br J Haematol 2016 Oct;175(1):102-14. Epub 2016 Jun 24 doi: 10.1111/bjh.14201. PMID: 27341313
Ho AL, Koch MJ, Tanaka S, Eichler AF, Batchelor TT, Tanboon J, Louis DN, Cahill DP, Chi AS, Curry WT Jr
J Clin Neurosci 2016 Sep;31:99-105. Epub 2016 Jun 6 doi: 10.1016/j.jocn.2016.02.019. PMID: 27279154
Yeh CY, Lin CL, Chang MC, Chen HM, Kok SH, Chang SH, Kuo YS, Hahn LJ, Chan CP, Lee JJ, Jeng JH
J Formos Med Assoc 2016 Apr;115(4):263-8. Epub 2015 Sep 26 doi: 10.1016/j.jfma.2015.07.017. PMID: 26412231

Prognosis

Alonso-Álvarez S, Magnano L, Alcoceba M, Andrade-Campos M, Espinosa-Lara N, Rodríguez G, Mercadal S, Carro I, Sancho JM, Moreno M, Salar A, García-Pallarols F, Arranz R, Cannata J, Terol MJ, Teruel AI, Rodríguez A, Jiménez-Ubieto A, González de Villambrosia S, Bello JL, López L, Monsalvo S, Novelli S, de Cabo E, Infante MS, Pardal E, García-Álvarez M, Delgado J, González M, Martín A, López-Guillermo A, Caballero MD
Br J Haematol 2017 Sep;178(5):699-708. Epub 2017 Aug 7 doi: 10.1111/bjh.14831. PMID: 28782811
Mendez M, Torrente M, Provencio M
Expert Rev Hematol 2017 Jun;10(6):515-524. Epub 2017 May 16 doi: 10.1080/17474086.2017.1326812. PMID: 28480766
Labarrere CA, DiCarlo HL, Bammerlin E, Hardin JW, Kim YM, Chaemsaithong P, Haas DM, Kassab GS, Romero R
Am J Obstet Gynecol 2017 Mar;216(3):287.e1-287.e16. Epub 2016 Dec 27 doi: 10.1016/j.ajog.2016.12.029. PMID: 28034657
Santoro A, Frankland PW, Richards BA
J Neurosci 2016 Nov 30;36(48):12228-12242. doi: 10.1523/JNEUROSCI.0763-16.2016. PMID: 27903731
Ho AL, Koch MJ, Tanaka S, Eichler AF, Batchelor TT, Tanboon J, Louis DN, Cahill DP, Chi AS, Curry WT Jr
J Clin Neurosci 2016 Sep;31:99-105. Epub 2016 Jun 6 doi: 10.1016/j.jocn.2016.02.019. PMID: 27279154

Clinical prediction guides

Alonso-Álvarez S, Magnano L, Alcoceba M, Andrade-Campos M, Espinosa-Lara N, Rodríguez G, Mercadal S, Carro I, Sancho JM, Moreno M, Salar A, García-Pallarols F, Arranz R, Cannata J, Terol MJ, Teruel AI, Rodríguez A, Jiménez-Ubieto A, González de Villambrosia S, Bello JL, López L, Monsalvo S, Novelli S, de Cabo E, Infante MS, Pardal E, García-Álvarez M, Delgado J, González M, Martín A, López-Guillermo A, Caballero MD
Br J Haematol 2017 Sep;178(5):699-708. Epub 2017 Aug 7 doi: 10.1111/bjh.14831. PMID: 28782811
Kridel R, Sehn LH, Gascoyne RD
Blood 2017 Jul 20;130(3):258-266. Epub 2017 Apr 13 doi: 10.1182/blood-2017-03-691345. PMID: 28408460
Labarrere CA, DiCarlo HL, Bammerlin E, Hardin JW, Kim YM, Chaemsaithong P, Haas DM, Kassab GS, Romero R
Am J Obstet Gynecol 2017 Mar;216(3):287.e1-287.e16. Epub 2016 Dec 27 doi: 10.1016/j.ajog.2016.12.029. PMID: 28034657
Speiseder T, Hofmann-Sieber H, Rodríguez E, Schellenberg A, Akyüz N, Dierlamm J, Spruss T, Lange C, Dobner T
J Virol 2017 Jan 1;91(1) Epub 2016 Dec 16 doi: 10.1128/JVI.01782-16. PMID: 27795433Free PMC Article
Wang Y, Zhang Z, Wang H, Zhang Y, Ji M, Xu H, Wang C, Sun Z, Gao W, Wang SL
Arch Toxicol 2016 May;90(5):1239-49. Epub 2015 Jun 18 doi: 10.1007/s00204-015-1551-4. PMID: 26084420

Recent systematic reviews

Suh CH, Kim KW, Pyo J, Lee J, Kim SY, Park SH
AJR Am J Roentgenol 2017 Oct;209(4):781-789. Epub 2017 Jul 25 doi: 10.2214/AJR.16.17711. PMID: 28742376
Kridel R, Sehn LH, Gascoyne RD
Blood 2017 Jul 20;130(3):258-266. Epub 2017 Apr 13 doi: 10.1182/blood-2017-03-691345. PMID: 28408460
Kietpeerakool C, Chumworathayi B, Thinkhamrop J, Ussahgij B, Lumbiganon P
Cochrane Database Syst Rev 2017 Jan 21;1:CD009957. doi: 10.1002/14651858.CD009957.pub2. PMID: 28109160
Zhao QY, Lei PJ, Zhang X, Zheng JY, Wang HY, Zhao J, Li YM, Ye M, Li L, Wei G, Wu M
Clin Epigenetics 2016;8:34. Epub 2016 Mar 31 doi: 10.1186/s13148-016-0201-x. PMID: 27034728Free PMC Article
Anderson A, Ishak N
Evid Based Dent 2015 Dec;16(4):102-3. doi: 10.1038/sj.ebd.6401128. PMID: 26680515

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