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Items: 10

1.

Tranylcypromine

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311) [from MeSH]

MedGen UID:
52818
Concept ID:
C0040778
Organic Chemical; Pharmacologic Substance
2.

Trifluoperazine

A phenothiazine derivative and a dopamine antagonist with antipsychotic and antiemetic activities. Trifluoperazine exerts its antipsychotic effect by blocking central dopamine receptors, thereby preventing effects such as delusions and hallucinations caused by an excess of dopamine. This agent also functions as a calmodulin inhibitor, thereby leading to elevation of cytosolic calcium. [from NCI]

MedGen UID:
21679
Concept ID:
C0040979
Organic Chemical; Pharmacologic Substance
3.

Borderline personality disorder

MedGen UID:
14197
Concept ID:
C0006012
Mental or Behavioral Dysfunction
4.

Alprazolam

A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability. [from NCI]

MedGen UID:
1436
Concept ID:
C0002333
Organic Chemical; Pharmacologic Substance
5.

Carbamazepine

MedGen UID:
745
Concept ID:
C0006949
Organic Chemical; Pharmacologic Substance
6.

Borderline

Having a minor degree of severity that is considered to be on the boundary between the normal and the abnormal ranges. For quantitative traits, a deviation of that is less than two standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
59969
Concept ID:
C0205189
Qualitative Concept
7.

Personality disorder

MedGen UID:
45827
Concept ID:
C0031212
Mental or Behavioral Dysfunction
8.

Jatrosom

MedGen UID:
296061
Concept ID:
C1564448
Organic Chemical; Pharmacologic Substance
9.

Tranylcypromine sulfate

The sulfate salt form of tranylcypromine, an orally bioavailable, nonselective, irreversible, non-hydrazine inhibitor of both monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1/BHC110), with antidepressant and anxiolytic activities, and potential antineoplastic activities. Upon oral administration, tranylcypromine exerts its antidepressant and anxiolytic effects through the inhibition of MAO, an enzyme that catalyzes the breakdown of the monoamine neurotransmitters serotonin, norepinephrine, epinephrine and dopamine. This increases the concentrations and activity of these neurotransmitters. Tranylcypromine exerts its antineoplastic effect through the inhibition of LSD1. Inhibition of LSD1 prevents the transcription of LSD1 target genes. LSD1, a flavin-dependent monoamine oxidoreductase and a histone demethylase, is upregulated in a variety of cancers and plays a key role in tumor cell proliferation, migration, and invasion. [from NCI]

MedGen UID:
86264
Concept ID:
C0304369
Organic Chemical; Pharmacologic Substance
10.

Trifluoperazine hydrochloride

The hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects. Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium. [from NCI]

MedGen UID:
81338
Concept ID:
C0304381
Organic Chemical; Pharmacologic Substance
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