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Items: 20

1.

Thrombosis

Formation and development of a thrombus or blood clot in the blood vessel. [from MeSH]

MedGen UID:
21160
Concept ID:
C0040053
Pathologic Function
2.

Antithrombin III preparation

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily. [from MeSH]

MedGen UID:
1993
Concept ID:
C0003438
Amino Acid, Peptide, or Protein; Pharmacologic Substance
3.

Thyroid hormone plasma membrane transport defect

MedGen UID:
396060
Concept ID:
C1861101
Disease or Syndrome
4.

Antithrombin III deficiency

Deficiency of antithrombin III is a major risk factor for venous thromboembolic disease. Two categories of AT-III deficiency have been defined on the basis of AT-III antigen levels in the plasma of affected individuals. The majority of AT-III deficiency families belong in the type I (classic) deficiency group and have a quantitatively abnormal phenotype in which antigen and heparin cofactor levels are both reduced to about 50% of normal. The second category of AT-III deficiency has been termed type II (functional) deficiency. Affected individuals from these kindreds produce dysfunctional AT-III molecules; they have reduced heparin cofactor activity levels (about 50% of normal) but levels of AT-III antigen are often normal or nearly normal (summary by Bock and Prochownik, 1987). The 2 categories of antithrombmin III deficiency have been classified further. Type I (low functional and immunologic antithrombin) has been subdivided into subtype Ia (reduced levels of normal antithrombin), and type Ib (reduced levels of antithrombin and the presence of low levels of a variant). Type II (low functional but normal immunologic antithrombin) has been subdivided into subtype IIa (functional abnormalities affecting both the reactive site and the heparin-binding site of AT3); subtype IIb (functional abnormalities limited to the reactive site); and subtype IIc (functional abnormalities limited to the heparin-binding site) (summary by Lane et al., 1992). [from GTR]

MedGen UID:
75781
Concept ID:
C0272375
Disease or Syndrome
5.

Reduced antithrombin III activity

MedGen UID:
65975
Concept ID:
C0238665
Finding
6.

Direct thrombin inhibitor

Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins. [from MeSH]

MedGen UID:
354
Concept ID:
C0003440
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
7.

Antithrombin Proteins

An endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin. Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance. [from MeSH]

MedGen UID:
422377
Concept ID:
C2936528
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
8.

Atenativ

MedGen UID:
303933
Concept ID:
C1448439
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
9.

Blood Coagulation Disorders, Inherited

Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation. [from MeSH]

MedGen UID:
163105
Concept ID:
C0852077
Disease or Syndrome
10.

Kybernin

MedGen UID:
136413
Concept ID:
C0651143
Amino Acid, Peptide, or Protein; Pharmacologic Substance
11.

Thrombus

MedGen UID:
43439
Concept ID:
C0087086
Pathologic Function
12.

Embolism and thrombosis

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
43147
Concept ID:
C0085307
Disease or Syndrome
13.

Vascular disorder

A non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels. Examples include vasculitis, thrombophlebitis, arteriosclerosis, lymphedema, hemangioma, and angiosarcoma. [from NCI]

MedGen UID:
22621
Concept ID:
C0042373
Disease or Syndrome
14.

Hemic and Lymphatic Diseases

Hematologic diseases and diseases of the lymphatic system collectively. Hemic diseases include disorders involving the formed elements (e.g., ERYTHROCYTE AGGREGATION, INTRAVASCULAR) and chemical components (e.g., BLOOD PROTEIN DISORDERS); lymphatic diseases include disorders relating to lymph, lymph nodes, and lymphocytes. [from MeSH]

MedGen UID:
6780
Concept ID:
C0018981
Disease or Syndrome
15.

Genetic Linkage

The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME. [from MeSH]

MedGen UID:
6102
Concept ID:
C0023745
Molecular Function
16.

Hematologic disease

An abnormality of the hematopoietic system. [from HPO]

MedGen UID:
5483
Concept ID:
C0018939
Disease or Syndrome
17.

Blood Protein Disorders

Hematologic diseases caused by structural or functional defects of BLOOD PROTEINS. [from MeSH]

MedGen UID:
612
Concept ID:
C0005830
Disease or Syndrome
18.

Abnormality of the coagulation cascade

A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood. [from NCI]

MedGen UID:
604
Concept ID:
C0005779
Disease or Syndrome
19.

Anticoagulant allergy

MedGen UID:
655532
Concept ID:
C0571773
Finding
20.

Antithrombin III allergy

MedGen UID:
655520
Concept ID:
C0571760
Disease or Syndrome
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