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Items: 1 to 20 of 71

1.

Multiple myeloma

Multiple myeloma is a neoplastic plasma cell disorder characterized by clonal proliferation of malignant plasma cells in the bone marrow microenvironment, monoclonal protein in the blood or urine, and associated organ dysfunction (Palumbo and Anderson, 2011). [from GTR]

MedGen UID:
10122
Concept ID:
C0026764
Neoplastic Process
2.

Multiple myeloma

A malignant plasma cell tumor growing within soft tissue or within the skeleton. [from HPO]

MedGen UID:
505979
Concept ID:
CN005898
Finding
3.

Prednisone

A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver. [from MeSH]

MedGen UID:
46064
Concept ID:
C0032952
Hormone; Organic Chemical; Pharmacologic Substance
4.

Lymphoma

A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells. [from HPO]

MedGen UID:
44223
Concept ID:
C0024299
Neoplastic Process
5.

Adriamycin

MedGen UID:
39101
Concept ID:
C0085752
Organic Chemical; Pharmacologic Substance
6.

Vincristine

A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04) [from NCI]

MedGen UID:
21863
Concept ID:
C0042679
Organic Chemical; Pharmacologic Substance
7.

Dexamethasone

A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04) [from NCI]

MedGen UID:
8344
Concept ID:
C0011777
Organic Chemical; Pharmacologic Substance
8.

Melphalan

A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. [from NCI]

MedGen UID:
6293
Concept ID:
C0025241
Amino Acid, Peptide, or Protein; Pharmacologic Substance
9.

IgA myeloma

MedGen UID:
647612
Concept ID:
C0563305
Neoplastic Process
10.

Lymphoma

A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells. [from HPO]

MedGen UID:
505322
Concept ID:
CN002422
Finding
11.

IgA

IgA is the immunoglobulin subclass that is associated with antibody-mediated mucosal immunity. It is secreted as dimers into the mucosa and is the most effective isotype at fixing complement by the alternative pathway, even though it lacks the ability to fix complement by the classical pathway. There are two subtypes in the human - IgA1 and IgA2. [from NCI]

MedGen UID:
442957
Concept ID:
C2825347
Immunologic Factor; Pharmacologic Substance
12.

Remission phase

An abatement in intensity or degree (as in the manifestations of a disease). [from NCI]

MedGen UID:
154255
Concept ID:
C0544452
Finding
13.

Symmetrical dyschromatosis of extremities

Dyschromatosis symmetrica hereditaria (DSH), also called symmetric dyschromatosis of the extremities and symmetric or reticulate acropigmentation of Dohi (Komaya, 1924), is characterized by hyperpigmented and hypopigmented macules on the face and dorsal aspects of the extremities that appear in infancy or early childhood. DSH generally shows an autosomal dominant pattern of inheritance with high penetrance. The condition has been reported predominantly in Japanese and Chinese individuals. Review of Reticulate Pigment Disorders Muller et al. (2012) reviewed the spectrum of reticulate pigment disorders of the skin, tabulating all reported cases of patients with Dowling-Degos disease (see DDD1; 179850), reticulate acropigmentation of Kitamura (RAK; 615537), reticulate acropigmentation of Dohi (RAD), Galli-Galli disease (GGD), and Haber syndrome (HS). Of 82 cases, 26 (31.7%) were clinically diagnosed as DDD, 13 (15.9%) as RAD, 11 (13.4%) as GGD, 8 (9.8%) as RAK, and 8 (9.8%) as HS; in addition, 16 (19.5%) of the cases showed overlap between DDD and RAK. Muller et al. (2012) also published photographs of an affected individual exhibiting an overlap of clinical features of DDD, GGD, RAD, and RAK. The authors noted that in reticulate disorders of the skin, the main disease entity is DDD, with a subset of cases exhibiting acantholysis (GGD), facial erythema (HS), or an acral distribution (RAD; RAK). Muller et al. (2012) concluded that all reticulate pigment diseases of the skin are varying manifestations of a single entity. Genetic Heterogeneity of Reticulate Pigment Disorders For a discussion of genetic heterogeneity of reticulate pigment disorders, see 179850. [from GTR]

MedGen UID:
96071
Concept ID:
C0406775
Congenital Abnormality
14.

Frequent

Coming at short intervals or in great quantities. [from NCI]

MedGen UID:
87144
Concept ID:
C0332183
Temporal Concept
15.

Immunoglobulin G

An immunoglobulin isotype (subclass) that characterizes secondary immune responses. This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli. [from NCI]

MedGen UID:
9407
Concept ID:
C0020852
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
16.

Adriablastin

MedGen UID:
423645
Concept ID:
C2936928
Organic Chemical; Pharmacologic Substance
17.

Plasma Cell Neoplasm

A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance. [from NCI]

MedGen UID:
368758
Concept ID:
C1959632
Neoplastic Process
18.

Dexpak

MedGen UID:
328371
Concept ID:
C1720761
Organic Chemical; Pharmacologic Substance
19.

Farmiblastina

MedGen UID:
307476
Concept ID:
C1512059
Organic Chemical; Pharmacologic Substance
20.

Onkodox

MedGen UID:
297409
Concept ID:
C1564916
Organic Chemical; Pharmacologic Substance
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