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Items: 2

1.

Sodium selenite

An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation. [from NCI]

MedGen UID:
56965
Concept ID:
C0142923
Inorganic Chemical; Pharmacologic Substance
2.

Selenite

MedGen UID:
19922
Concept ID:
C0036580
Inorganic Chemical; Pharmacologic Substance

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