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Meprobamate

MedGen UID:
6310
Concept ID:
C0025386
Organic Chemical; Pharmacologic Substance
Synonyms: 1,3-Propanediol, 2-methyl-2-propyl-, dicarbamate
SNOMED CT: Meprobamate (70864001); Meprobamate (387395007)
 

Definition

A carbamate derivate with hypnotic, anti-anxiety, sedative, anticonvulsant and some indirect muscle relaxant properties. Although the exact mechanism of meprobamate is largely unknown, it appears to act as a depressant at multiple sites in the central nervous system, mostly likely through the GABAergic neurotransmitter system, including the thalamus and limbic system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeprobamate

Recent clinical studies

Etiology

Lu A, Scott KS, Chan-Hosokawa A, Logan BK
J Anal Toxicol 2017 Mar 1;41(2):134-139. doi: 10.1093/jat/bkw106. PMID: 27798072
James AO, Nicholson TR, Hill R, Bearn J
BMJ Case Rep 2016 Feb 29;2016 doi: 10.1136/bcr-2015-213606. PMID: 26929223
Bévalot F, Gustin MP, Cartiser N, Gaillard Y, Le Meur C, Fanton L, Guitton J, Malicier D
Int J Legal Med 2013 Sep;127(5):915-21. Epub 2013 Feb 12 doi: 10.1007/s00414-013-0833-8. PMID: 23400420
Kumar A, Xagoraraki I
Regul Toxicol Pharmacol 2010 Jul-Aug;57(2-3):146-56. Epub 2010 Feb 10 doi: 10.1016/j.yrtph.2010.02.002. PMID: 20152876
Charron C, Mekontso-Dessap A, Chergui K, Rabiller A, Jardin F, Vieillard-Baron A
Intensive Care Med 2005 Nov;31(11):1582-6. Epub 2005 Oct 11 doi: 10.1007/s00134-005-2816-9. PMID: 16217659

Diagnosis

Kumar M, Dillon GH
Eur J Pharmacol 2016 Mar 15;775:149-58. Epub 2016 Feb 9 doi: 10.1016/j.ejphar.2016.02.031. PMID: 26872987Free PMC Article
Zaïem A, Kaabi W, Badri T, Lakhoua G, Sahnoun R, Kastalli S, Daghfous R, Lakhal M, El Aidli S
Curr Drug Saf 2014;9(2):161-2. PMID: 24446836
Bévalot F, Gustin MP, Cartiser N, Gaillard Y, Le Meur C, Fanton L, Guitton J, Malicier D
Int J Legal Med 2013 Sep;127(5):915-21. Epub 2013 Feb 12 doi: 10.1007/s00414-013-0833-8. PMID: 23400420
McIntyre IM, Sherrard J, Lucas J
J Anal Toxicol 2012 Apr;36(3):177-81. doi: 10.1093/jat/bks011. PMID: 22417833
Alvarez JC, Duverneuil C, Zouaoui K, Abe E, Charlier P, de la Grandmaison GL, Grassin-Delyle S
Clin Chim Acta 2012 Jan 18;413(1-2):273-7. Epub 2011 Oct 26 doi: 10.1016/j.cca.2011.10.025. PMID: 22057036

Therapy

James AO, Nicholson TR, Hill R, Bearn J
BMJ Case Rep 2016 Feb 29;2016 doi: 10.1136/bcr-2015-213606. PMID: 26929223
Zaïem A, Kaabi W, Badri T, Lakhoua G, Sahnoun R, Kastalli S, Daghfous R, Lakhal M, El Aidli S
Curr Drug Saf 2014;9(2):161-2. PMID: 24446836
Ceschi A, Berger D, Dickenmann M, Bodmer M
Hemodial Int 2013 Oct;17(4):656-9. Epub 2013 Apr 25 doi: 10.1111/hdi.12047. PMID: 23615322
McIntyre IM, Sherrard J, Lucas J
J Anal Toxicol 2012 Apr;36(3):177-81. doi: 10.1093/jat/bks011. PMID: 22417833
Fathallah N, Zamy M, Slim R, Fain O, Hmouda H, Bouraoui K, Ben Salem C, Biour M
JOP 2011 Jul 8;12(4):404-6. PMID: 21737904

Prognosis

Fathallah N, Zamy M, Slim R, Fain O, Hmouda H, Bouraoui K, Ben Salem C, Biour M
JOP 2011 Jul 8;12(4):404-6. PMID: 21737904
Pok PR, Mauras M, De Saint Léger MN, Kuhlmann E, Charpenel-Durat C, Navarette C, Duval ML, De Meo P
Leg Med (Tokyo) 2010 Nov;12(6):300-4. Epub 2010 Sep 25 doi: 10.1016/j.legalmed.2010.08.002. PMID: 20870445
Fanton L, Bevalot F, Gustin MP, Paultre CZ, Le Meur C, Malicier D
Int J Legal Med 2009 Mar;123(2):97-102. Epub 2008 Jun 26 doi: 10.1007/s00414-008-0259-x. PMID: 18581126
Charron C, Mekontso-Dessap A, Chergui K, Rabiller A, Jardin F, Vieillard-Baron A
Intensive Care Med 2005 Nov;31(11):1582-6. Epub 2005 Oct 11 doi: 10.1007/s00134-005-2816-9. PMID: 16217659
Bramness JG, Skurtveit S, Fauske L, Grung M, Molven A, Mørland J, Steen VM
Pharmacogenetics 2003 Jul;13(7):383-8. doi: 10.1097/01.fpc.0000054098.48725.88. PMID: 12835613

Clinical prediction guides

Kumar M, Dillon GH
Eur J Pharmacol 2016 Mar 15;775:149-58. Epub 2016 Feb 9 doi: 10.1016/j.ejphar.2016.02.031. PMID: 26872987Free PMC Article
Ceschi A, Berger D, Dickenmann M, Bodmer M
Hemodial Int 2013 Oct;17(4):656-9. Epub 2013 Apr 25 doi: 10.1111/hdi.12047. PMID: 23615322
Kumar A, Xagoraraki I
Regul Toxicol Pharmacol 2010 Jul-Aug;57(2-3):146-56. Epub 2010 Feb 10 doi: 10.1016/j.yrtph.2010.02.002. PMID: 20152876
Daval S, Richard D, Souweine B, Eschalier A, Coudore F
J Anal Toxicol 2006 Jun;30(5):302-5. PMID: 16839465
Charron C, Mekontso-Dessap A, Chergui K, Rabiller A, Jardin F, Vieillard-Baron A
Intensive Care Med 2005 Nov;31(11):1582-6. Epub 2005 Oct 11 doi: 10.1007/s00134-005-2816-9. PMID: 16217659

Recent systematic reviews

Richards BL, Whittle SL, Buchbinder R
Cochrane Database Syst Rev 2012 Jan 18;1:CD008922. doi: 10.1002/14651858.CD008922.pub2. PMID: 22258993
Prescrire Int 2008 Oct;17(97):206-12. PMID: 19536941
Hughes JR, Stead LF, Lancaster T
Cochrane Database Syst Rev 2000;(4):CD002849. doi: 10.1002/14651858.CD002849. PMID: 11034774
Glazener CM, Evans JH
Cochrane Database Syst Rev 2000;(3):CD002238. doi: 10.1002/14651858.CD002238. PMID: 10908533
Hughes JR, Stead LF, Lancaster T
Cochrane Database Syst Rev 2000;(2):CD000031. doi: 10.1002/14651858.CD000031. PMID: 10796472

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