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Items: 16

1.

Bazedoxifene

An indole derivative and third-generation selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Upon administration, bazedoxifene specifically binds to estrogen receptors in responsive tissues, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it either promotes or suppresses the transcription of estrogen-regulated genes. Bazedoxifene acts as an estrogen antagonist in uterine and breast tissue, thereby blocking the proliferative effects of estrogen-binding to ER-positive cells in these tissues. Bazedoxifene functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In bone, it decreases bone resorption and bone turnover and increases bone mineral density. [from NCI]

MedGen UID:
378523
Concept ID:
C2346970
Organic Chemical; Pharmacologic Substance
2.

Conjugated Equine Estrogens

MedGen UID:
253945
Concept ID:
C1136013
Hormone; Organic Chemical; Pharmacologic Substance
3.

Atherosclerosis

Atherosclerosis is a disease in which plaque builds up inside your arteries. Plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. That limits the flow of oxygen-rich blood to your body. Atherosclerosis can lead to serious problems, including. -Coronary artery disease. These arteries supply blood to your heart. When they are blocked, you can suffer angina or a heart attack. -Carotid artery disease. These arteries supply blood to your brain. When they are blocked you can suffer a stroke. -Peripheral arterial disease. These arteries are in your arms, legs and pelvis. When they are blocked, you can suffer from numbness, pain and sometimes infections. Atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. Many people don't know they have it until they have a medical emergency. A physical exam, imaging, and other diagnostic tests can tell if you have it. Medicines can slow the progress of plaque buildup. Your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. Lifestyle changes can also help. These include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. . NIH: National Heart, Lung, and Blood Institute.  [from MedlinePlus]

MedGen UID:
13948
Concept ID:
C0004153
Disease or Syndrome
4.

Estrogens

A class of natural or synthetic hormones that binds to a cytoplasmic receptor and initiates translocation of the hormone-receptor complex to the nucleus of target cells of tissues rich in estrogen receptors, including the endometrium, myometrium, oviduct, vagina, fallopian tube, cervix, brain, liver, placenta, ovarian cells, Leydigs cells, kidney, prostate, pancreas, heart, and skin. (NCI) [from NCI]

MedGen UID:
8701
Concept ID:
C0014939
Hormone; Organic Chemical; Pharmacologic Substance
5.

Cerebral artery atherosclerosis

Atherosclerosis (HP:0002621) of a cerebral artery. [from HPO]

MedGen UID:
870478
Concept ID:
C4024924
Anatomical Abnormality; Disease or Syndrome
6.

Postmenopausal state

Having to do with the time after menopause. Menopause ("change of life") is the time in a woman's life when menstrual periods stop permanently. [from NCI_NCI-GLOSS]

MedGen UID:
65432
Concept ID:
C0232970
Finding
7.

Oestrofeminal

MedGen UID:
346343
Concept ID:
C1617817
Hormone; Organic Chemical; Pharmacologic Substance
8.

Carentil

MedGen UID:
344973
Concept ID:
C1569522
Hormone; Organic Chemical; Pharmacologic Substance
9.

Progens

MedGen UID:
301073
Concept ID:
C1618332
Hormone; Organic Chemical; Pharmacologic Substance
10.

Prelestrin

MedGen UID:
301067
Concept ID:
C1617307
Hormone; Organic Chemical; Pharmacologic Substance
11.

Transannon

MedGen UID:
299052
Concept ID:
C1579776
Hormone; Organic Chemical; Pharmacologic Substance
12.

Dagynil

MedGen UID:
293951
Concept ID:
C1569521
Hormone; Organic Chemical; Pharmacologic Substance
13.

Congest

MedGen UID:
152141
Concept ID:
C0700150
Hormone; Organic Chemical; Pharmacologic Substance
14.

Presomen

MedGen UID:
152112
Concept ID:
C0699711
Hormone; Organic Chemical; Pharmacologic Substance
15.

Premarin

estrogen supplement drug used to relieve menopausal symptoms [from CHV]

MedGen UID:
152111
Concept ID:
C0699710
Hormone; Organic Chemical; Pharmacologic Substance
16.

Bazedoxifene acetate

MedGen UID:
345470
Concept ID:
C1571574
Organic Chemical; Pharmacologic Substance
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