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N-Myristoylation

MedGen UID:
307880
Concept ID:
C1513807
Molecular Function
 

Definition

N-Myristoylation is the covalent attachment of myristic acid, a saturated 14-carbon fatty acid inserted in the cytoplasmic leaflet of the lipid bilayer, by an amide linkage to the amino-terminal glycine residue of a protein in order to increase the hydrophobicity of some membrane proteins or to promote membrane localization of some cytoplasmic proteins. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVN-Myristoylation

Recent clinical studies

Etiology

Morita D, Sugita M
Immunology 2016 Oct;149(2):139-45. Epub 2016 Aug 10 doi: 10.1111/imm.12646. PMID: 27402593Free PMC Article
Das U, Kumar S, Dimmock JR, Sharma RK
Curr Cancer Drug Targets 2012 Jul;12(6):667-92. PMID: 22463587
Maurer-Stroh S, Eisenhaber B, Eisenhaber F
J Mol Biol 2002 Apr 5;317(4):523-40. doi: 10.1006/jmbi.2002.5425. PMID: 11955007
Zha J, Weiler S, Oh KJ, Wei MC, Korsmeyer SJ
Science 2000 Dec 1;290(5497):1761-5. PMID: 11099414
Wang Y, Windh RT, Chen CA, Manning DR
J Biol Chem 1999 Dec 24;274(52):37435-42. PMID: 10601316

Diagnosis

Rajanikanth V, Sharma AK, Rajyalakshmi M, Chandra K, Chary KV, Sharma Y
Biochemistry 2015 Feb 3;54(4):1111-22. Epub 2015 Jan 21 doi: 10.1021/bi501134g. PMID: 25565019
Goncalves V, Brannigan JA, Thinon E, Olaleye TO, Serwa R, Lanzarone S, Wilkinson AJ, Tate EW, Leatherbarrow RJ
Anal Biochem 2012 Feb 1;421(1):342-4. Epub 2011 Oct 14 doi: 10.1016/j.ab.2011.10.013. PMID: 22051857Free PMC Article
Martinez A, Traverso JA, Valot B, Ferro M, Espagne C, Ephritikhine G, Zivy M, Giglione C, Meinnel T
Proteomics 2008 Jul;8(14):2809-31. doi: 10.1002/pmic.200701191. PMID: 18655050
Maurer-Stroh S, Eisenhaber B, Eisenhaber F
J Mol Biol 2002 Apr 5;317(4):541-57. doi: 10.1006/jmbi.2002.5426. PMID: 11955008
Johnson DR, Knoll LJ, Levin DE, Gordon JI
J Cell Biol 1994 Nov;127(3):751-62. PMID: 7962057Free PMC Article

Therapy

Ochi A, Abe T, Nakao R, Yamamoto Y, Kitahata K, Takagi M, Hirasaka K, Ohno A, Teshima-Kondo S, Taesik G, Choi I, Kawamura T, Nemoto H, Mukai R, Terao J, Nikawa T
Arch Biochem Biophys 2015 Mar 15;570:23-31. Epub 2015 Feb 14 doi: 10.1016/j.abb.2015.02.006. PMID: 25689493
Paul P, Chowdhury A, Das Talukdar A, Choudhury MD
J Mol Model 2015 Mar;21(3):37. Epub 2015 Feb 7 doi: 10.1007/s00894-015-2586-4. PMID: 25663521
Zhao C, Ma S
ChemMedChem 2014 Nov;9(11):2425-37. Epub 2014 Aug 14 doi: 10.1002/cmdc.201402174. PMID: 25125080
Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW
Nat Chem 2014 Feb;6(2):112-21. Epub 2013 Dec 22 doi: 10.1038/nchem.1830. PMID: 24451586Free PMC Article
Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG
Nature 2010 Apr 1;464(7289):728-32. doi: 10.1038/nature08893. PMID: 20360736Free PMC Article

Prognosis

Takamitsu E, Otsuka M, Haebara T, Yano M, Matsuzaki K, Kobuchi H, Moriya K, Utsumi T
PLoS One 2015;10(8):e0136360. Epub 2015 Aug 26 doi: 10.1371/journal.pone.0136360. PMID: 26308446Free PMC Article
Moriya K, Nagatoshi K, Noriyasu Y, Okamura T, Takamitsu E, Suzuki T, Utsumi T
PLoS One 2013;8(11):e78235. Epub 2013 Nov 4 doi: 10.1371/journal.pone.0078235. PMID: 24223779Free PMC Article
Traverso JA, Giglione C, Meinnel T
Proteomics 2013 Jan;13(1):25-36. doi: 10.1002/pmic.201200375. PMID: 23165749
Maurer-Stroh S, Eisenhaber B, Eisenhaber F
J Mol Biol 2002 Apr 5;317(4):541-57. doi: 10.1006/jmbi.2002.5426. PMID: 11955008
Maurer-Stroh S, Eisenhaber B, Eisenhaber F
J Mol Biol 2002 Apr 5;317(4):523-40. doi: 10.1006/jmbi.2002.5425. PMID: 11955007

Clinical prediction guides

Paape D, Bell AS, Heal WP, Hutton JA, Leatherbarrow RJ, Tate EW, Smith DF
PLoS Negl Trop Dis 2014 Dec;8(12):e3363. Epub 2014 Dec 18 doi: 10.1371/journal.pntd.0003363. PMID: 25522361Free PMC Article
Moriya K, Nagatoshi K, Noriyasu Y, Okamura T, Takamitsu E, Suzuki T, Utsumi T
PLoS One 2013;8(11):e78235. Epub 2013 Nov 4 doi: 10.1371/journal.pone.0078235. PMID: 24223779Free PMC Article
Traverso JA, Giglione C, Meinnel T
Proteomics 2013 Jan;13(1):25-36. doi: 10.1002/pmic.201200375. PMID: 23165749
Beauchamp E, Tekpli X, Marteil G, Lagadic-Gossmann D, Legrand P, Rioux V
Biochimie 2009 Nov-Dec;91(11-12):1411-9. Epub 2009 Jul 30 doi: 10.1016/j.biochi.2009.07.014. PMID: 19647031
Sakurai N, Utsumi T
J Biol Chem 2006 May 19;281(20):14288-95. Epub 2006 Mar 23 doi: 10.1074/jbc.M510338200. PMID: 16556605

Recent systematic reviews

Gnanasekar M, Anand SB, Ramaswamy K
DNA Seq 2008 Apr;19(2):151-6. doi: 10.1080/10425170701517614. PMID: 17852334Free PMC Article
Maurer-Stroh S, Eisenhaber B, Eisenhaber F
J Mol Biol 2002 Apr 5;317(4):523-40. doi: 10.1006/jmbi.2002.5425. PMID: 11955007

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