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Items: 1 to 20 of 21

1.

Acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is associated with 2 cardinal features: a granulocytic differentiation block and reciprocal and balanced translocations that always involve rearrangement of the RARA gene (180240). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (102578) and represents more than 98% of APL (Vitoux et al., 2007). [from GTR]

MedGen UID:
44127
Concept ID:
C0023487
Neoplastic Process
2.

Acute myeloid leukemia

CEBPA-associated familial acute myeloid leukemia (AML) is defined as AML in which a heterozygous germline CEBPA pathogenic variant is present in a family in which multiple individuals have AML. In contrast, sporadic CEBPA-associated AML is defined as AML in which a CEBPA pathogenic variant(s) is identified in leukemic cells but not in the non-leukemic cells. Too few individuals with CEBPA-associated familial AML have been reported to be certain about the natural history of the disease. In the majority of individuals, the age of onset of familial AML appears to be earlier than sporadic AML; disease onset has been reported in persons as young as age 1.8 years and older than age 45 years. The prognosis of CEBPA-associated familial AML appears to be favorable compared with sporadic CEBPA-associated AML. Individuals with CEBPA-associated familial AML who have been cured of their initial disease may be at greater risk of developing additional independent leukemic episodes in addition to the risk of relapse due to preexisting clones. [from GTR]

MedGen UID:
9730
Concept ID:
C0023467
Neoplastic Process
3.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [from HPO]

MedGen UID:
9725
Concept ID:
C0023418
Neoplastic Process
4.

Acute promyelocytic leukemia

A type of acute myeloid leukemia in which abnormal promyelocytes predominate. [from HPO]

MedGen UID:
505697
Concept ID:
CN004281
Finding
5.

Acute

Sudden appearance of disease manifestations over a short period of time. [from HPO]

MedGen UID:
61381
Concept ID:
C0205178
Temporal Concept
6.

Tretinoin

A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties. [from NCI]

MedGen UID:
21254
Concept ID:
C0040845
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
7.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
8.

Atrichia with papular lesions

The patients are born with hair that falls out and is not replaced. Histologic studies show malformation of the hair follicles. Papillary lesions over most of the body and almost complete absence of hair are features. [from SNOMEDCT_US]

MedGen UID:
395299
Concept ID:
C1859592
Disease or Syndrome
9.

Acute myeloid leukemia with maturation

An acute myeloid leukemia (AML) characterized by blasts with evidence of maturation to more mature neutrophils. (WHO, 2001) [from NCI]

MedGen UID:
361829
Concept ID:
C1879321
Neoplastic Process
10.

Retin-A

MedGen UID:
109266
Concept ID:
C0593762
Organic Chemical; Pharmacologic Substance
11.

Vesanoid

MedGen UID:
108874
Concept ID:
C0595126
Organic Chemical; Pharmacologic Substance
12.

Retinol

The fat soluble vitamin retinol. Vitamin A binds to and activates retinoid receptors (RARs), thereby inducing cell differentiation and apoptosis of some cancer cell types and inhibiting carcinogenesis. Vitamin A plays an essential role in many physiologic processes, including proper functioning of the retina, growth and differentiation of target tissues, proper functioning of the reproductive organs, and modulation of immune function. [from NCI]

MedGen UID:
88691
Concept ID:
C0087161
Organic Chemical; Pharmacologic Substance; Vitamin
13.

Retinoid

A group of agents that includes retinol (Vitamin A) and related compounds with potential antineoplastic and/or chemopreventive activities. A retinoic acid agent binds to and/or activates specific nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), thereby modulating transcription of genes responsible for cell differentiation and proliferation. A retinoic acid agent may exhibit immunomodulatory and anti-inflammatory properties and may inhibit ornithine decarboxylase, resulting in a decrease in polyamine synthesis and keratinization. (NCI04) [from NCI]

MedGen UID:
48436
Concept ID:
C0035339
Organic Chemical; Pharmacologic Substance
14.

Vitamin A

Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. [from MeSH]

MedGen UID:
12111
Concept ID:
C0042839
Organic Chemical; Pharmacologic Substance; Vitamin
15.

Neoplasms by Histologic Type

A collective term for the various histological types of NEOPLASMS. It is more likely to be used by searchers than by indexers and catalogers. [from MeSH]

MedGen UID:
10295
Concept ID:
C0027652
Neoplastic Process
16.

Chronic Monocytic Leukemia

MedGen UID:
9729
Concept ID:
C0023466
Neoplastic Process
17.

Myeloid leukemia

A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia. [from NCI]

MedGen UID:
7320
Concept ID:
C0023470
Neoplastic Process
18.

Ether

An organic compound in which two carbon atoms are linked through an oxygen atom (C-O-C). An ether may be a product of the condensation of alcohols. Ether also refers loosely to diethyl-ether, a colorless, volatile, highly inflammable liquid used in industry and biomedical research, and historically important as an anesthetic agent. In vivo, ether acts similarly to alcohol and chloroform, but its stimulant action on the heart is much more marked. Ether is a rapidly diffusible stimulant. (NCI04) [from NCI]

MedGen UID:
4564
Concept ID:
C0014996
Organic Chemical; Pharmacologic Substance
19.

Carotinoid

A class of hydrocarbons (carotenes) and their oxygenated derivatives which exhibit chemopreventive properties. Carotenoids are pigments found in green, yellow, and leafy vegetables, and yellow fruits. The pigments are fat-soluble, unsaturated aliphatic hydrocarbons functioning as provitamins and are converted to vitamin A through enzymatic processes in the intestinal wall. [from NCI]

MedGen UID:
2890
Concept ID:
C0007271
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
20.

all trans retinoic acid (ATRA) response

MedGen UID:
833964
Concept ID:
CN230750
Sign or Symptom
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