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Relapsing remitting multiple sclerosis

MedGen UID:
155669
Concept ID:
C0751967
Disease or Syndrome
Synonyms: Multiple Sclerosis, Relapsing Remitting; Multiple Sclerosis, Relapsing-Remitting; Multiple Sclerosis, Remitting-Relapsing; Relapsing Remitting Multiple Sclerosis; Relapsing-Remitting Multiple Sclerosis; Remitting Relapsing Multiple Sclerosis; Remitting-Relapsing Multiple Sclerosis
SNOMED CT: Relapsing remitting multiple sclerosis (426373005); Multiple sclerosis (MS) relapsing remitting (426373005)
 
Monarch Initiative: MONDO:0005314

Definition

A type of multiple sclerosis characterized by intermittent flare-ups with a return to few or no symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRelapsing remitting multiple sclerosis

Professional guidelines

PubMed

Freeman L, Longbrake EE, Coyle PK, Hendin B, Vollmer T
CNS Drugs 2022 Dec;36(12):1285-1299. Epub 2022 Nov 9 doi: 10.1007/s40263-022-00965-7. PMID: 36350491Free PMC Article
Correale J, Gaitán MI, Ysrraelit MC, Fiol MP
Brain 2017 Mar 1;140(3):527-546. doi: 10.1093/brain/aww258. PMID: 27794524
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Curated

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

Svenningsson A, Frisell T, Burman J, Salzer J, Fink K, Hallberg S, Hambraeus J, Axelsson M, Nimer FA, Sundström P, Gunnarsson M, Johansson R, Mellergård J, Rosenstein I, Ayad A, Sjöblom I, Risedal A, de Flon P, Gilland E, Lindeberg J, Shawket F, Piehl F, Lycke J
Lancet Neurol 2022 Aug;21(8):693-703. doi: 10.1016/S1474-4422(22)00209-5. PMID: 35841908
Kaegi C, Wuest B, Crowley C, Boyman O
Front Immunol 2021;12:788830. Epub 2022 Feb 2 doi: 10.3389/fimmu.2021.788830. PMID: 35185862Free PMC Article
Liu Z, Liao Q, Wen H, Zhang Y
Autoimmun Rev 2021 Jun;20(6):102826. Epub 2021 Apr 18 doi: 10.1016/j.autrev.2021.102826. PMID: 33878488
Giovannoni G, Soelberg Sorensen P, Cook S, Rammohan K, Rieckmann P, Comi G, Dangond F, Adeniji AK, Vermersch P
Mult Scler 2018 Oct;24(12):1594-1604. Epub 2017 Sep 5 doi: 10.1177/1352458517727603. PMID: 28870107
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Diagnosis

Freeman L, Longbrake EE, Coyle PK, Hendin B, Vollmer T
CNS Drugs 2022 Dec;36(12):1285-1299. Epub 2022 Nov 9 doi: 10.1007/s40263-022-00965-7. PMID: 36350491Free PMC Article
Olek MJ
Ann Intern Med 2021 Jun;174(6):ITC81-ITC96. Epub 2021 Jun 8 doi: 10.7326/AITC202106150. PMID: 34097429
Liu Z, Liao Q, Wen H, Zhang Y
Autoimmun Rev 2021 Jun;20(6):102826. Epub 2021 Apr 18 doi: 10.1016/j.autrev.2021.102826. PMID: 33878488
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Therapy

Klotz L, Antel J, Kuhlmann T
Nat Rev Neurol 2023 May;19(5):305-320. Epub 2023 Apr 14 doi: 10.1038/s41582-023-00801-6. PMID: 37059811
Svenningsson A, Frisell T, Burman J, Salzer J, Fink K, Hallberg S, Hambraeus J, Axelsson M, Nimer FA, Sundström P, Gunnarsson M, Johansson R, Mellergård J, Rosenstein I, Ayad A, Sjöblom I, Risedal A, de Flon P, Gilland E, Lindeberg J, Shawket F, Piehl F, Lycke J
Lancet Neurol 2022 Aug;21(8):693-703. doi: 10.1016/S1474-4422(22)00209-5. PMID: 35841908
Foley JF, Defer G, Ryerson LZ, Cohen JA, Arnold DL, Butzkueven H, Cutter G, Giovannoni G, Killestein J, Wiendl H, Smirnakis K, Xiao S, Kong G, Kuhelj R, Campbell N; NOVA study investigators
Lancet Neurol 2022 Jul;21(7):608-619. Epub 2022 Apr 25 doi: 10.1016/S1474-4422(22)00143-0. PMID: 35483387
Giovannoni G, Soelberg Sorensen P, Cook S, Rammohan K, Rieckmann P, Comi G, Dangond F, Adeniji AK, Vermersch P
Mult Scler 2018 Oct;24(12):1594-1604. Epub 2017 Sep 5 doi: 10.1177/1352458517727603. PMID: 28870107
Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, Fox RJ, Bar-Or A, Panzara M, Sarkar N, Agarwal S, Langer-Gould A, Smith CH; HERMES Trial Group
N Engl J Med 2008 Feb 14;358(7):676-88. doi: 10.1056/NEJMoa0706383. PMID: 18272891

Prognosis

Edan G, Le Page E
Drugs 2023 Oct;83(15):1351-1363. Epub 2023 Sep 19 doi: 10.1007/s40265-023-01942-0. PMID: 37725259Free PMC Article
Zhuo Z, Li Y, Duan Y, Cao G, Zheng F, Ding J, Tian D, Wang X, Wang J, Zhang X, Li K, Zhou F, Huang M, Li Y, Li H, Zeng C, Zhang N, Sun J, Yu C, Han X, Haller S, Barkhof F, Shi F, Liu Y
J Neurol 2021 May;268(5):1808-1817. Epub 2021 Jan 2 doi: 10.1007/s00415-020-10376-7. PMID: 33387013
He A, Merkel B, Brown JWL, Zhovits Ryerson L, Kister I, Malpas CB, Sharmin S, Horakova D, Kubala Havrdova E, Spelman T, Izquierdo G, Eichau S, Trojano M, Lugaresi A, Hupperts R, Sola P, Ferraro D, Lycke J, Grand'Maison F, Prat A, Girard M, Duquette P, Larochelle C, Svenningsson A, Petersen T, Grammond P, Granella F, Van Pesch V, Bergamaschi R, McGuigan C, Coles A, Hillert J, Piehl F, Butzkueven H, Kalincik T; MSBase study group
Lancet Neurol 2020 Apr;19(4):307-316. Epub 2020 Mar 18 doi: 10.1016/S1474-4422(20)30067-3. PMID: 32199096
Bar-Or A, Grove RA, Austin DJ, Tolson JM, VanMeter SA, Lewis EW, Derosier FJ, Lopez MC, Kavanagh ST, Miller AE, Sorensen PS
Neurology 2018 May 15;90(20):e1805-e1814. Epub 2018 Apr 25 doi: 10.1212/WNL.0000000000005516. PMID: 29695594Free PMC Article
Wingerchuk DM, Carter JL
Mayo Clin Proc 2014 Feb;89(2):225-40. doi: 10.1016/j.mayocp.2013.11.002. PMID: 24485135

Clinical prediction guides

Müller J, Schädelin S, Lorscheider J, Benkert P, Hänni P, Schmid J, Kuhle J, Derfuss T, Granziera C, Yaldizli Ö
Eur J Neurol 2023 Dec;30(12):3809-3818. Epub 2023 Aug 29 doi: 10.1111/ene.16044. PMID: 37578431
Boz C, Ozakbas S, Terzi M, Karabudak R, Sevim S, Turkoglu R, Soysal A, Balcı BP, Efendi H, Turan ÖF, Yüceyar N, Yetkin MF, Karahan SZ, Demirkıran M, Guler S, Agan K, Kıylıoğlu N, Baba C, Tuncer A, Köseoğlu M
Neurol Sci 2023 Jun;44(6):2121-2129. Epub 2023 Jan 23 doi: 10.1007/s10072-023-06608-z. PMID: 36689010
Spelman T, Magyari M, Piehl F, Svenningsson A, Rasmussen PV, Kant M, Sellebjerg F, Joensen H, Hillert J, Lycke J
JAMA Neurol 2021 Oct 1;78(10):1197-1204. doi: 10.1001/jamaneurol.2021.2738. PMID: 34398221Free PMC Article
Rodrigues R, Rocha R, Bonifácio G, Ferro D, Sabença F, Gonçalves AI, Correia F, Pinheiro J, Loureiro JL, Guerreiro RP, Vale J, Sá MJ, Costa A
Mult Scler Relat Disord 2021 Oct;55:103176. Epub 2021 Jul 27 doi: 10.1016/j.msard.2021.103176. PMID: 34343868
Naismith RT, Wundes A, Ziemssen T, Jasinska E, Freedman MS, Lembo AJ, Selmaj K, Bidollari I, Chen H, Hanna J, Leigh-Pemberton R, Lopez-Bresnahan M, Lyons J, Miller C, Rezendes D, Wolinsky JS; EVOLVE-MS-2 Study Group
CNS Drugs 2020 Feb;34(2):185-196. doi: 10.1007/s40263-020-00700-0. PMID: 31953790Free PMC Article

Recent systematic reviews

Montalban X, Matthews PM, Simpson A, Petrie JL, Sammon C, Ramagopalan S, Disanto G, Kuhle J
Ann Clin Transl Neurol 2023 Mar;10(3):302-311. Epub 2023 Feb 2 doi: 10.1002/acn3.51732. PMID: 36728340Free PMC Article
Liu Z, Liao Q, Wen H, Zhang Y
Autoimmun Rev 2021 Jun;20(6):102826. Epub 2021 Apr 18 doi: 10.1016/j.autrev.2021.102826. PMID: 33878488
Naseri A, Nasiri E, Sahraian MA, Daneshvar S, Talebi M
Mult Scler Relat Disord 2021 May;50:102816. Epub 2021 Feb 4 doi: 10.1016/j.msard.2021.102816. PMID: 33571792
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

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