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Aging

MedGen UID:
1376
Concept ID:
C0001811
Organism Function
Synonyms: AGING
SNOMED CT: Aging (248280005)
 
OMIM®: 502000

Definition

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from GTR]

Additional description

From OMIM
Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999).  http://www.omim.org/entry/502000

Recent systematic reviews

Renteria AE, Mfuna Endam L, Desrosiers M
Otolaryngol Head Neck Surg 2017 Apr;156(4):598-605. Epub 2017 Feb 14 doi: 10.1177/0194599817691258. PMID: 28195747
Pace JE, Grenier A
J Gerontol B Psychol Sci Soc Sci 2017 Mar 1;72(2):248-258. doi: 10.1093/geronb/gbw128. PMID: 27729385
Carver LF, Buchanan D
Clin Interv Aging 2016;11:1623-1630. Epub 2016 Nov 11 doi: 10.2147/CIA.S117202. PMID: 27956828Free PMC Article
Zhuang S, Wang HF, Wang X, Li J, Xing CM
J Clin Neurosci 2016 Nov;33:32-38. Epub 2016 Jul 27 doi: 10.1016/j.jocn.2016.02.036. PMID: 27475317
Gonzalez-Freire M, de Cabo R, Bernier M, Sollott SJ, Fabbri E, Navas P, Ferrucci L
J Gerontol A Biol Sci Med Sci 2015 Nov;70(11):1334-42. Epub 2015 May 20 doi: 10.1093/gerona/glv070. PMID: 25995290Free PMC Article

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