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Heroin

MedGen UID:
41524
Concept ID:
C0011892
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
Synonyms: Diacetylmorphine; Diamorphine; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester)
SNOMED CT: Heroin (60881009); Diacetylmorphine (60881009); Heroin (387341002); Diacetylmorphine (387341002)
 

Definition

A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeroin

Recent clinical studies

Etiology

O'Donnell JK, Gladden RM, Seth P
MMWR Morb Mortal Wkly Rep 2017 Sep 1;66(34):897-903. doi: 10.15585/mmwr.mm6634a2. PMID: 28859052
Fareed A, Kim J, Ketchen B, Kwak WJ, Wang D, Shongo-Hiango H, Drexler K
J Addict Dis 2017 Apr-Jun;36(2):105-116. Epub 2017 Jan 17 doi: 10.1080/10550887.2017.1280898. PMID: 28095255
Willman MW, Liss DB, Schwarz ES, Mullins ME
Clin Toxicol (Phila) 2017 Feb;55(2):81-87. Epub 2016 Nov 16 doi: 10.1080/15563650.2016.1253846. PMID: 27849133
Ellis AD, McGwin G, Davis GG, Dye DW
Forensic Sci Med Pathol 2016 Sep;12(3):243-7. Epub 2016 Apr 25 doi: 10.1007/s12024-016-9780-2. PMID: 27114260Free PMC Article
Mital S, Miles G, McLellan-Lemal E, Muthui M, Needle R
Int J Drug Policy 2016 Apr;30:91-8. Epub 2015 Aug 22 doi: 10.1016/j.drugpo.2015.08.010. PMID: 26470646Free PMC Article

Diagnosis

Ellis AD, McGwin G, Davis GG, Dye DW
Forensic Sci Med Pathol 2016 Sep;12(3):243-7. Epub 2016 Apr 25 doi: 10.1007/s12024-016-9780-2. PMID: 27114260Free PMC Article
Armentia A, Pineda F, Martin-Armentia B, Ramos C, Gil Martin FJ, Palacios R
Allergol Immunopathol (Madr) 2016 Sep-Oct;44(5):472-4. Epub 2016 Apr 15 doi: 10.1016/j.aller.2015.12.003. PMID: 27087565
Madry MM, Bosshard MM, Kraemer T, Baumgartner MR
Bioanalysis 2016 May;8(9):953-64. Epub 2016 Apr 12 doi: 10.4155/bio-2016-0019. PMID: 27067523
Palamar JJ, Shearston JA, Dawson EW, Mateu-Gelabert P, Ompad DC
Drug Alcohol Depend 2016 Jan 1;158:132-8. Epub 2015 Nov 21 doi: 10.1016/j.drugalcdep.2015.11.005. PMID: 26653341Free PMC Article
Liu C, Hua Z, Bai Y
Forensic Sci Int 2015 Dec;257:196-202. Epub 2015 Aug 20 doi: 10.1016/j.forsciint.2015.08.009. PMID: 26364155

Therapy

O'Donnell JK, Gladden RM, Seth P
MMWR Morb Mortal Wkly Rep 2017 Sep 1;66(34):897-903. doi: 10.15585/mmwr.mm6634a2. PMID: 28859052
Fareed A, Kim J, Ketchen B, Kwak WJ, Wang D, Shongo-Hiango H, Drexler K
J Addict Dis 2017 Apr-Jun;36(2):105-116. Epub 2017 Jan 17 doi: 10.1080/10550887.2017.1280898. PMID: 28095255
Willman MW, Liss DB, Schwarz ES, Mullins ME
Clin Toxicol (Phila) 2017 Feb;55(2):81-87. Epub 2016 Nov 16 doi: 10.1080/15563650.2016.1253846. PMID: 27849133
Lefaucheur R, Lebas A, Gérardin E, Grangeon L, Ozkul-Wermester O, Aubier-Girard C, Martinaud O, Maltête D
J Clin Neurosci 2017 Jan;35:70-72. Epub 2016 Oct 11 doi: 10.1016/j.jocn.2016.09.023. PMID: 27742371
Maas A, Krämer M, Sydow K, Chen PS, Dame T, Musshoff F, Diehl BW, Madea B, Hess C
Drug Test Anal 2017 Mar;9(3):470-478. Epub 2016 Sep 29 doi: 10.1002/dta.2058. PMID: 27565444

Prognosis

O'Donnell JK, Gladden RM, Seth P
MMWR Morb Mortal Wkly Rep 2017 Sep 1;66(34):897-903. doi: 10.15585/mmwr.mm6634a2. PMID: 28859052
Rodda LN, Pilgrim JL, Di Rago M, Crump K, Gerostamoulos D, Drummer OH
J Anal Toxicol 2017 May 1;41(4):318-324. doi: 10.1093/jat/bkx013. PMID: 28158759
Lefaucheur R, Lebas A, Gérardin E, Grangeon L, Ozkul-Wermester O, Aubier-Girard C, Martinaud O, Maltête D
J Clin Neurosci 2017 Jan;35:70-72. Epub 2016 Oct 11 doi: 10.1016/j.jocn.2016.09.023. PMID: 27742371
Jones JD, Vadhan NP, Luba RR, Comer SD
J Clin Exp Neuropsychol 2016 Aug;38(6):709-20. Epub 2016 Apr 10 doi: 10.1080/13803395.2016.1156652. PMID: 27062912Free PMC Article
Lin SH, Chen KC, Lee SY, Chiu NT, Lee IH, Chen PS, Yeh TL, Lu RB, Chen CC, Liao MH, Yang YK
Psychiatry Res 2015 Mar 30;231(3):292-7. Epub 2015 Jan 19 doi: 10.1016/j.pscychresns.2015.01.011. PMID: 25659472

Clinical prediction guides

Rodda LN, Pilgrim JL, Di Rago M, Crump K, Gerostamoulos D, Drummer OH
J Anal Toxicol 2017 May 1;41(4):318-324. doi: 10.1093/jat/bkx013. PMID: 28158759
Willman MW, Liss DB, Schwarz ES, Mullins ME
Clin Toxicol (Phila) 2017 Feb;55(2):81-87. Epub 2016 Nov 16 doi: 10.1080/15563650.2016.1253846. PMID: 27849133
Lefaucheur R, Lebas A, Gérardin E, Grangeon L, Ozkul-Wermester O, Aubier-Girard C, Martinaud O, Maltête D
J Clin Neurosci 2017 Jan;35:70-72. Epub 2016 Oct 11 doi: 10.1016/j.jocn.2016.09.023. PMID: 27742371
Maas A, Krämer M, Sydow K, Chen PS, Dame T, Musshoff F, Diehl BW, Madea B, Hess C
Drug Test Anal 2017 Mar;9(3):470-478. Epub 2016 Sep 29 doi: 10.1002/dta.2058. PMID: 27565444
Jones JD, Vadhan NP, Luba RR, Comer SD
J Clin Exp Neuropsychol 2016 Aug;38(6):709-20. Epub 2016 Apr 10 doi: 10.1080/13803395.2016.1156652. PMID: 27062912Free PMC Article

Recent systematic reviews

Fareed A, Kim J, Ketchen B, Kwak WJ, Wang D, Shongo-Hiango H, Drexler K
J Addict Dis 2017 Apr-Jun;36(2):105-116. Epub 2017 Jan 17 doi: 10.1080/10550887.2017.1280898. PMID: 28095255
Willman MW, Liss DB, Schwarz ES, Mullins ME
Clin Toxicol (Phila) 2017 Feb;55(2):81-87. Epub 2016 Nov 16 doi: 10.1080/15563650.2016.1253846. PMID: 27849133
Broséus J, Gentile N, Esseiva P
Forensic Sci Int 2016 May;262:73-83. Epub 2016 Feb 26 doi: 10.1016/j.forsciint.2016.02.033. PMID: 26974713
Strang J, Groshkova T, Uchtenhagen A, van den Brink W, Haasen C, Schechter MT, Lintzeris N, Bell J, Pirona A, Oviedo-Joekes E, Simon R, Metrebian N
Br J Psychiatry 2015 Jul;207(1):5-14. doi: 10.1192/bjp.bp.114.149195. PMID: 26135571
Farrell M, Hall W
Br J Psychiatry 2015 Jul;207(1):3-4. doi: 10.1192/bjp.bp.114.160986. PMID: 26135569

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