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Items: 5

1.

Atrophy

Any weakening or degeneration, especially through lack of use. [from NCI]

MedGen UID:
83084
Concept ID:
C0333641
Pathologic Function
2.

Cerebral cortical atrophy

Atrophy of the cortex of the cerebrum. [from HPO]

MedGen UID:
505113
Concept ID:
CN001920
Finding
3.

Brain atrophy

Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum. [from HPO]

MedGen UID:
116012
Concept ID:
C0235946
Disease or Syndrome
4.

Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper motor neurons (UMN) and lower motor neurons (LMN). UMN signs include hyperreflexia, extensor plantar response, increased muscle tone, and weakness in a topographic representation. LMN signs include weakness, muscle wasting, hyporeflexia, muscle cramps, and fasciculations. Initial presentation varies. Affected individuals typically present with either asymmetric focal weakness of the extremities (stumbling or poor handgrip) or bulbar findings (dysarthria, dysphagia). Other findings may include muscle fasciculations, muscle cramps, and labile affect, but not necessarily mood. Regardless of initial symptoms, atrophy and weakness eventually affect other muscles. The mean age of onset is 56 years in individuals with no known family history and 46 years in individuals with more than one affected family member (familial ALS or FALS). Average disease duration is about three years, but it can vary significantly. Death usually results from compromise of the respiratory muscles. [from GTR]

MedGen UID:
274
Concept ID:
C0002736
Disease or Syndrome
5.

Atrophy/Degeneration affecting the brainstem

MedGen UID:
870454
Concept ID:
C4024900
Disease or Syndrome
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