Format

Send to:

Choose Destination

Links from PubMed

Licorice

MedGen UID:
162348
Concept ID:
C0770612
Organic Chemical; Pharmacologic Substance
Synonyms: Licorice Root Extract
 

Definition

An herbal extract derived from the root of the plant Glycyrrhiza glabra with potential anti-inflammatory, antioxidant, and antineoplastic activities. Licorice root extract contains glycoside glycyrrhizinic acid and numerous flavonoids. Glycyrrhizinic acid in licorice root extract is hydrolyzed to glycyrrhetic acid (GA); GA inhibits 11 beta-hydroxysteroid dehydrogenase, resulting in inhibition of the conversion of cortisol to the inactive steroid cortisone and elevated cortisol levels. In addition, GA inhibits 17,20-lyase and 17 beta-hydroxysteroid dehydrogenase, resulting in decreased conversions of 17-hydroxyprogesterone to androstenedione and androstenedione to testosterone. The primary antioxidant found in licorice root, the flavonoid glabridin, may inactivate or inhibit the activities of some cytochrome P450 enzymes. In tumor cells, beta-hydroxy-DHP, another flavonoid, may induce Bcl-2 phosphorylation, apoptosis, and G2/M cell cycle arrest. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLicorice

Recent clinical studies

Etiology

Abu-Awwad A, Arafat T, Schmitz OJ
J Pharm Biomed Anal 2017 Jan 5;132:60-65. Epub 2016 Sep 28 doi: 10.1016/j.jpba.2016.09.026. PMID: 27693954
Yang R, Yuan BC, Ma YS, Zhou S, Liu Y
Pharm Biol 2017 Dec;55(1):5-18. Epub 2016 Sep 21 doi: 10.1080/13880209.2016.1225775. PMID: 27650551
Ghalayani P, Emami H, Pakravan F, Nasr Isfahani M
Asia Pac J Clin Oncol 2017 Apr;13(2):e48-e56. Epub 2014 Oct 28 doi: 10.1111/ajco.12295. PMID: 25347930
Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A
Health Care Women Int 2014 Jan;35(1):87-99. Epub 2013 May 10 doi: 10.1080/07399332.2013.770001. PMID: 23663094
Ruetzler K, Fleck M, Nabecker S, Pinter K, Landskron G, Lassnigg A, You J, Sessler DI
Anesth Analg 2013 Sep;117(3):614-21. Epub 2013 Aug 6 doi: 10.1213/ANE.0b013e318299a650. PMID: 23921656

Diagnosis

Hataya Y, Oba A, Yamashita T, Komatsu Y
Intern Med 2017;56(2):175-179. Epub 2017 Jan 15 doi: 10.2169/internalmedicine.56.6438. PMID: 28090048Free PMC Article
Abu-Awwad A, Arafat T, Schmitz OJ
J Pharm Biomed Anal 2017 Jan 5;132:60-65. Epub 2016 Sep 28 doi: 10.1016/j.jpba.2016.09.026. PMID: 27693954
Ghalayani P, Emami H, Pakravan F, Nasr Isfahani M
Asia Pac J Clin Oncol 2017 Apr;13(2):e48-e56. Epub 2014 Oct 28 doi: 10.1111/ajco.12295. PMID: 25347930
Ottenbacher R, Blehm J
S D Med 2015 Aug;68(8):346-7, 349. PMID: 26380428
Celik MM, Karakus A, Zeren C, Demir M, Bayarogullari H, Duru M, Al M
Hum Exp Toxicol 2012 Dec;31(12):1295-8. Epub 2012 May 31 doi: 10.1177/0960327112446843. PMID: 22653692

Therapy

Yang R, Yuan BC, Ma YS, Zhou S, Liu Y
Pharm Biol 2017 Dec;55(1):5-18. Epub 2016 Sep 21 doi: 10.1080/13880209.2016.1225775. PMID: 27650551
Ghalayani P, Emami H, Pakravan F, Nasr Isfahani M
Asia Pac J Clin Oncol 2017 Apr;13(2):e48-e56. Epub 2014 Oct 28 doi: 10.1111/ajco.12295. PMID: 25347930
Ottenbacher R, Blehm J
S D Med 2015 Aug;68(8):346-7, 349. PMID: 26380428
Makino T
Biol Pharm Bull 2014;37(6):898-902. PMID: 24882402
Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A
Health Care Women Int 2014 Jan;35(1):87-99. Epub 2013 May 10 doi: 10.1080/07399332.2013.770001. PMID: 23663094

Prognosis

Räikkönen K, Martikainen S, Pesonen AK, Lahti J, Heinonen K, Pyhälä R, Lahti M, Tuovinen S, Wehkalampi K, Sammallahti S, Kuula L, Andersson S, Eriksson JG, Ortega-Alonso A, Reynolds RM, Strandberg TE, Seckl JR, Kajantie E
Am J Epidemiol 2017 Mar 1;185(5):317-328. doi: 10.1093/aje/kww172. PMID: 28158597
Huang QC, Wang MJ, Chen XM, Yu WL, Chu YL, He XH, Huang RY
Oncotarget 2016 Jan 12;7(2):1193-202. doi: 10.18632/oncotarget.6200. PMID: 26498361Free PMC Article
Tassinari D, Bergamaschi R, Corsini I, Landini S, Romanin B, Ballarini E, De Ponti F, Carfagnini F, Toni F, Bernardi F
Pediatr Neurol 2015 Apr;52(4):457-9. Epub 2014 Dec 11 doi: 10.1016/j.pediatrneurol.2014.12.001. PMID: 25680999
Yoshino T, Yanagawa T, Watanabe K
J Altern Complement Med 2014 Jun;20(6):516-20. Epub 2014 Mar 12 doi: 10.1089/acm.2013.0454. PMID: 24620820
Panduranga P, Al-Rawahi N
Ann Noninvasive Electrocardiol 2013 Nov;18(6):593-6. Epub 2013 Sep 9 doi: 10.1111/anec.12076. PMID: 24303973

Clinical prediction guides

Abu-Awwad A, Arafat T, Schmitz OJ
J Pharm Biomed Anal 2017 Jan 5;132:60-65. Epub 2016 Sep 28 doi: 10.1016/j.jpba.2016.09.026. PMID: 27693954
Yang R, Yuan BC, Ma YS, Zhou S, Liu Y
Pharm Biol 2017 Dec;55(1):5-18. Epub 2016 Sep 21 doi: 10.1080/13880209.2016.1225775. PMID: 27650551
Kinoshita T, Matsumoto A, Yoshino K, Furukawa S
J Sci Food Agric 2017 Jun;97(8):2339-2345. Epub 2016 Nov 11 doi: 10.1002/jsfa.8044. PMID: 27643690
Ghalayani P, Emami H, Pakravan F, Nasr Isfahani M
Asia Pac J Clin Oncol 2017 Apr;13(2):e48-e56. Epub 2014 Oct 28 doi: 10.1111/ajco.12295. PMID: 25347930
Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A
Health Care Women Int 2014 Jan;35(1):87-99. Epub 2013 May 10 doi: 10.1080/07399332.2013.770001. PMID: 23663094

Recent systematic reviews

Yang R, Yuan BC, Ma YS, Zhou S, Liu Y
Pharm Biol 2017 Dec;55(1):5-18. Epub 2016 Sep 21 doi: 10.1080/13880209.2016.1225775. PMID: 27650551
Shergis JL, Wu L, Zhang AL, Guo X, Lu C, Xue CC
J Asthma 2016 Aug;53(6):650-9. Epub 2016 May 12 doi: 10.3109/02770903.2015.1101473. PMID: 27172294
Kristanc L, Kreft S
Food Chem Toxicol 2016 Jun;92:150-64. Epub 2016 Apr 14 doi: 10.1016/j.fct.2016.04.007. PMID: 27090581
Park SJ, Yi B, Lee HS, Oh WY, Na HK, Lee M, Yang M
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(1):33-56. doi: 10.1080/10590501.2015.1131539. PMID: 26669465
Tang ZH, Li T, Tong YG, Chen XJ, Chen XP, Wang YT, Lu JJ
Planta Med 2015 Dec;81(18):1670-87. Epub 2015 Dec 22 doi: 10.1055/s-0035-1558227. PMID: 26695708

Supplemental Content

Table of contents

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    Support Center