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Isotretinoin

MedGen UID:
9584
Concept ID:
C0022265
Organic Chemical; Pharmacologic Substance
Synonyms: 13 cis Retinoic Acid; 13-cis-Retinoic Acid; Retinoic acid, 13-cis-
SNOMED CT: Isotretinoin (387208003); 13-cis-Retinoic acid (387208003); Topical form isotretinoin (429464002); Isotretinoin (38314008); 13-cis-Retinoic acid (38314008)
 

Definition

A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIsotretinoin

Recent clinical studies

Etiology

Huang YC, Cheng YC
J Am Acad Dermatol 2017 Jun;76(6):1068-1076.e9. Epub 2017 Mar 11 doi: 10.1016/j.jaad.2016.12.028. PMID: 28291553
Kadakia S, Badhey A, Milam M, Lee T, Ducic Y
Laryngoscope 2017 Jul;127(7):1595-1599. Epub 2016 Dec 21 doi: 10.1002/lary.26463. PMID: 28000225
Baykal Selçuk L, Aksu Arıca D, Baykal Şahin H, Yaylı S, Bahadır S
Cutan Ocul Toxicol 2017 Jun;36(2):176-179. Epub 2016 Nov 16 doi: 10.1080/15569527.2016.1237521. PMID: 27764978
Yıldırım N, Doğan S, Atakan N
J Dermatolog Treat 2017 Mar;28(2):141-144. Epub 2016 Aug 8 doi: 10.1080/09546634.2016.1214232. PMID: 27425198
Yesilkaya B, Alli N, Artuz RF, Ulu E, Kartal D, Cinar SL
Cutan Ocul Toxicol 2017 Mar;36(1):74-76. Epub 2016 Mar 30 doi: 10.3109/15569527.2016.1155595. PMID: 26938860

Diagnosis

Polat M, Kükner Ş
Cutan Ocul Toxicol 2017 Mar;36(1):35-38. Epub 2016 Feb 24 doi: 10.3109/15569527.2016.1141419. PMID: 26911891
Uyar B, Solak A, Saklamaz A, Akyildiz M, Genc B, Gökduman A
Indian J Dermatol Venereol Leprol 2016 Sep-Oct;82(5):587-8. doi: 10.4103/0378-6323.182794. PMID: 27212279
Henry D, Dormuth C, Winquist B, Carney G, Bugden S, Teare G, Lévesque LE, Bérard A, Paterson JM, Platt RW; CNODES (Canadian Network for Observational Drug Effect Studies) Investigators.
CMAJ 2016 Jul 12;188(10):723-30. Epub 2016 Apr 25 doi: 10.1503/cmaj.151243. PMID: 27114489Free PMC Article
Seçkin HY, Baş Y, Takçı Z, Kalkan G
Cutan Ocul Toxicol 2016;35(2):89-91. Epub 2015 Apr 8 doi: 10.3109/15569527.2015.1021927. PMID: 25853176
Alkan S, Kayiran N, Zengin O, Kalem A, Kimyon G, Kilinc EO, Pehlivan Y, Kirtak N, Onat AM, Kisacik B
J Rheumatol 2015 Nov;42(11):2106-9. Epub 2015 Oct 15 doi: 10.3899/jrheum.150013. PMID: 26472411

Therapy

Huang YC, Cheng YC
J Am Acad Dermatol 2017 Jun;76(6):1068-1076.e9. Epub 2017 Mar 11 doi: 10.1016/j.jaad.2016.12.028. PMID: 28291553
Kadakia S, Badhey A, Milam M, Lee T, Ducic Y
Laryngoscope 2017 Jul;127(7):1595-1599. Epub 2016 Dec 21 doi: 10.1002/lary.26463. PMID: 28000225
Baykal Selçuk L, Aksu Arıca D, Baykal Şahin H, Yaylı S, Bahadır S
Cutan Ocul Toxicol 2017 Jun;36(2):176-179. Epub 2016 Nov 16 doi: 10.1080/15569527.2016.1237521. PMID: 27764978
Yesilkaya B, Alli N, Artuz RF, Ulu E, Kartal D, Cinar SL
Cutan Ocul Toxicol 2017 Mar;36(1):74-76. Epub 2016 Mar 30 doi: 10.3109/15569527.2016.1155595. PMID: 26938860
Polat M, Kükner Ş
Cutan Ocul Toxicol 2017 Mar;36(1):35-38. Epub 2016 Feb 24 doi: 10.3109/15569527.2016.1141419. PMID: 26911891

Prognosis

Prather HB, Alam M, Poon E, Arndt KA, Dover JS
Dermatol Surg 2017 Mar;43(3):357-363. doi: 10.1097/DSS.0000000000001019. PMID: 28005622
Baykal Selçuk L, Aksu Arıca D, Baykal Şahin H, Yaylı S, Bahadır S
Cutan Ocul Toxicol 2017 Jun;36(2):176-179. Epub 2016 Nov 16 doi: 10.1080/15569527.2016.1237521. PMID: 27764978
Miziołek B, Bergler-Czop B, Stańkowska A, Brzezińska-Wcisło L
Cutan Ocul Toxicol 2017 Mar;36(1):77-84. Epub 2016 May 10 doi: 10.3109/15569527.2016.1169284. PMID: 27160965
Hansen TJ, Lucking S, Miller JJ, Kirby JS, Thiboutot DM, Zaenglein AL
J Am Acad Dermatol 2016 Aug;75(2):323-8. Epub 2016 May 14 doi: 10.1016/j.jaad.2016.03.019. PMID: 27189824
Alkan S, Kayiran N, Zengin O, Kalem A, Kimyon G, Kilinc EO, Pehlivan Y, Kirtak N, Onat AM, Kisacik B
J Rheumatol 2015 Nov;42(11):2106-9. Epub 2015 Oct 15 doi: 10.3899/jrheum.150013. PMID: 26472411

Clinical prediction guides

Huang YC, Cheng YC
J Am Acad Dermatol 2017 Jun;76(6):1068-1076.e9. Epub 2017 Mar 11 doi: 10.1016/j.jaad.2016.12.028. PMID: 28291553
Prather HB, Alam M, Poon E, Arndt KA, Dover JS
Dermatol Surg 2017 Mar;43(3):357-363. doi: 10.1097/DSS.0000000000001019. PMID: 28005622
Yesilkaya B, Alli N, Artuz RF, Ulu E, Kartal D, Cinar SL
Cutan Ocul Toxicol 2017 Mar;36(1):74-76. Epub 2016 Mar 30 doi: 10.3109/15569527.2016.1155595. PMID: 26938860
Guadanhim LR, Gonçalves RG, Bagatin E
Int J Dermatol 2016 Nov;55(11):1255-1258. doi: 10.1111/ijd.13317. PMID: 27419807
Seçkin HY, Baş Y, Takçı Z, Kalkan G
Cutan Ocul Toxicol 2016;35(2):89-91. Epub 2015 Apr 8 doi: 10.3109/15569527.2015.1021927. PMID: 25853176

Recent systematic reviews

Huang YC, Cheng YC
J Am Acad Dermatol 2017 Jun;76(6):1068-1076.e9. Epub 2017 Mar 11 doi: 10.1016/j.jaad.2016.12.028. PMID: 28291553
Prather HB, Alam M, Poon E, Arndt KA, Dover JS
Dermatol Surg 2017 Mar;43(3):357-363. doi: 10.1097/DSS.0000000000001019. PMID: 28005622
Lee YH, Scharnitz TP, Muscat J, Chen A, Gupta-Elera G, Kirby JS
JAMA Dermatol 2016 Jan;152(1):35-44. doi: 10.1001/jamadermatol.2015.3091. PMID: 26630323
Lee SY, Jamal MM, Nguyen ET, Bechtold ML, Nguyen DL
Eur J Gastroenterol Hepatol 2016 Feb;28(2):210-6. doi: 10.1097/MEG.0000000000000496. PMID: 26545085
Rowe C, Spelman L, Oziemski M, Ryan A, Manoharan S, Wilson P, Daubney M, Scott J
Australas J Dermatol 2014 May;55(2):162-7. Epub 2013 Nov 28 doi: 10.1111/ajd.12117. PMID: 24283385

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