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Encephalomalacia

MedGen UID:
4936
Concept ID:
C0014068
Disease or Syndrome
Synonyms: Cerebral softening
SNOMED CT: Encephalomalacia (58762006)
 
HPO: HP:0040197

Definition

Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75) [from MeSH]

Conditions with this feature

Encephalomalacia, multilocular
MedGen UID:
341670
Concept ID:
C1856991
Disease or Syndrome

Recent clinical studies

Etiology

Elsayed H, Ng M, Rutherford M, Gupta R
BMJ Case Rep 2015 Mar 31;2015 doi: 10.1136/bcr-2013-202750. PMID: 25827913Free PMC Article
Bennett-Back O, Ochi A, Widjaja E, Nambu S, Kamiya A, Go C, Chuang S, Rutka JT, Drake J, Snead OC 3rd, Otsubo H
J Neurosurg Pediatr 2014 Sep;14(3):271-8. Epub 2014 Jul 11 doi: 10.3171/2014.6.PEDS13415. PMID: 25014323
Forrester KR, Keegan KM, Schmidt JW
J Neonatal Perinatal Med 2013;6(1):83-8. doi: 10.3233/NPM-1364512. PMID: 24246463
Park S, Hong JY, Lee MK, Koh HS, Kim EY
Seizure 2011 Sep;20(7):570-4. Epub 2011 May 28 doi: 10.1016/j.seizure.2011.04.007. PMID: 21620739
Sass JO, Gunduz A, Araujo Rodrigues Funayama C, Korkmaz B, Dantas Pinto KG, Tuysuz B, Yanasse Dos Santos L, Taskiran E, de Fátima Turcato M, Lam CW, Reiss J, Walter M, Yalcinkaya C, Camelo Junior JS
Brain Dev 2010 Aug;32(7):544-9. Epub 2009 Sep 29 doi: 10.1016/j.braindev.2009.09.005. PMID: 19793632

Diagnosis

Pan F, Wang JY, Xu Y, Huang ML
Medicine (Baltimore) 2017 Mar;96(10):e6310. doi: 10.1097/MD.0000000000006310. PMID: 28272261Free PMC Article
McMullen DP, Rosenberg P, Cheng J, Smith GS, Lyketsos C, Anderson WS
Alzheimer Dis Assoc Disord 2016 Jan-Mar;30(1):70-2. doi: 10.1097/WAD.0000000000000095. PMID: 25850733Free PMC Article
Elsayed H, Ng M, Rutherford M, Gupta R
BMJ Case Rep 2015 Mar 31;2015 doi: 10.1136/bcr-2013-202750. PMID: 25827913Free PMC Article
Georgescu A, Chiriac C, Tilea B, Kezdi I
Rev Med Chir Soc Med Nat Iasi 2012 Jul-Sep;116(3):799-803. PMID: 23272531
Matlung SE, Bilo RA, Kubat B, van Rijn RR
Forensic Sci Med Pathol 2011 Dec;7(4):355-63. Epub 2011 Apr 26 doi: 10.1007/s12024-011-9236-7. PMID: 21519862Free PMC Article

Therapy

McMullen DP, Rosenberg P, Cheng J, Smith GS, Lyketsos C, Anderson WS
Alzheimer Dis Assoc Disord 2016 Jan-Mar;30(1):70-2. doi: 10.1097/WAD.0000000000000095. PMID: 25850733Free PMC Article
Elsayed H, Ng M, Rutherford M, Gupta R
BMJ Case Rep 2015 Mar 31;2015 doi: 10.1136/bcr-2013-202750. PMID: 25827913Free PMC Article
Georgescu A, Chiriac C, Tilea B, Kezdi I
Rev Med Chir Soc Med Nat Iasi 2012 Jul-Sep;116(3):799-803. PMID: 23272531
Chang HT, Rumbeiha WK, Patterson JS, Puschner B, Knight AP
Vet Pathol 2012 Mar;49(2):398-402. Epub 2011 Apr 28 doi: 10.1177/0300985811406885. PMID: 21527781
Saie DJ, Sills ES
Neuro Endocrinol Lett 2005 Oct;26(5):533-5. PMID: 16264405

Prognosis

Park S, Hong JY, Lee MK, Koh HS, Kim EY
Seizure 2011 Sep;20(7):570-4. Epub 2011 May 28 doi: 10.1016/j.seizure.2011.04.007. PMID: 21620739
Mejías A, Bustos R, Ardura MI, Ramírez C, Sánchez PJ
J Perinatol 2009 Apr;29(4):290-6. Epub 2009 Feb 5 doi: 10.1038/jp.2008.235. PMID: 19194454
Bava S, Archibald SL, Trauner DA
J Child Neurol 2007 Jul;22(7):841-7. doi: 10.1177/0883073807304700. PMID: 17715276
Kazemi NJ, So EL, Mosewich RK, O'Brien TJ, Cascino GD, Trenerry MR, Sharbrough FW
Epilepsia 1997 Jun;38(6):670-7. PMID: 9186249
Dubois PJ, Heinz ER, Wessel HB, Zaias BW
J Comput Assist Tomogr 1979 Feb;3(1):97-102. PMID: 422799

Clinical prediction guides

Bennett-Back O, Ochi A, Widjaja E, Nambu S, Kamiya A, Go C, Chuang S, Rutka JT, Drake J, Snead OC 3rd, Otsubo H
J Neurosurg Pediatr 2014 Sep;14(3):271-8. Epub 2014 Jul 11 doi: 10.3171/2014.6.PEDS13415. PMID: 25014323
Forrester KR, Keegan KM, Schmidt JW
J Neonatal Perinatal Med 2013;6(1):83-8. doi: 10.3233/NPM-1364512. PMID: 24246463
Zucco GM, Prior M, Sartori G, Stevenson RJ
Cortex 2013 Feb;49(2):599-604. Epub 2012 Apr 11 doi: 10.1016/j.cortex.2012.04.002. PMID: 22578708
Park S, Hong JY, Lee MK, Koh HS, Kim EY
Seizure 2011 Sep;20(7):570-4. Epub 2011 May 28 doi: 10.1016/j.seizure.2011.04.007. PMID: 21620739
Tang X, Yin X, Zhang T, Peng H
Undersea Hyperb Med 2011 Mar-Apr;38(2):109-15. PMID: 21510270

Recent systematic reviews

West S, Nolan SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2015 Jul 1;(7):CD010541. doi: 10.1002/14651858.CD010541.pub2. PMID: 26130264
Hakimian S, Kershenovich A, Miller JW, Ojemann JG, Hebb AO, D'Ambrosio R, Ojemann GA
Neurosurg Focus 2012 Mar;32(3):E10. doi: 10.3171/2012.1.FOCUS11329. PMID: 22380851
Matlung SE, Bilo RA, Kubat B, van Rijn RR
Forensic Sci Med Pathol 2011 Dec;7(4):355-63. Epub 2011 Apr 26 doi: 10.1007/s12024-011-9236-7. PMID: 21519862Free PMC Article
Ajaz F, Kudva YC, Erwin PJ
Endocr Pract 2007 Jul-Aug;13(4):384-8. doi: 10.4158/EP.13.4.384. PMID: 17669715
Drapkin AJ
Childs Nerv Syst 2006 Apr;22(4):394-7. Epub 2005 Apr 22 doi: 10.1007/s00381-005-1158-9. PMID: 15856258

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