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BLOOD GROUP--LUTHERAN INHIBITOR(INLU)

MedGen UID:
266227
Concept ID:
C1292231
Finding
Synonyms: DOMINANT LU (a-b-) PHENOTYPE; INLU
SNOMED CT: dominant Lu(a-b-) phenotype (115824003); In(Lu) phenotype (115824003)
 
Gene (location): KLF1 (19p13.13)
OMIM®: 111150

Clinical features

Absence of Lutheran antigen on erythrocytes
MedGen UID:
869197
Concept ID:
C4023619
Anatomical Abnormality
Absence of the Lutheran antigen (a type I integral membrane glycoprotein) from the surface of red blood cells.

Recent clinical studies

Etiology

Pieters M, Barnard SA, Loots DT, Rijken DC
PLoS One 2017;12(2):e0171271. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0171271. PMID: 28158230Free PMC Article
Franchini M, Coppola A, Mengoli C, Rivolta GF, Riccardi F, Minno GD, Tagliaferri A; ad hoc Study Group.
Semin Thromb Hemost 2017 Feb;43(1):69-74. Epub 2016 Nov 8 doi: 10.1055/s-0036-1592166. PMID: 27825181
Li W, Chen W, Xie M, Huang H, Su H, Han H, Zhang D, Zhang Y, Yang X, Xu W, Su Y, Wu W, Huang Y, Fu K, Wei J
Ren Fail 2016 Oct;38(9):1359-1363. Epub 2016 Oct 19 doi: 10.1080/0886022X.2016.1214053. PMID: 27756191
Landsem A, Fure H, Mollnes TE, Nielsen EW, Brekke OL
Thromb Res 2016 Jul;143:63-70. Epub 2016 Apr 28 doi: 10.1016/j.thromres.2016.04.024. PMID: 27197075
Huang Y, Shen L, Cai A, Xiao J
J Tradit Chin Med 2015 Oct;35(5):571-6. PMID: 26591688

Diagnosis

Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Siravegna G, Sartore-Bianchi A, Mussolin B, Cassingena A, Amatu A, Novara L, Buscarino M, Corti G, Crisafulli G, Bartolini A, Tosi F, Erlander M, Di Nicolantonio F, Siena S, Bardelli A
Ann Oncol 2017 Jun 1;28(6):1302-1308. doi: 10.1093/annonc/mdx095. PMID: 28368455
Di Bartolomeo A, Chauleur C, Gris JC, Chapelle C, Noblot E, Laporte S, Raia-Barjat T
PLoS One 2017;12(3):e0173596. Epub 2017 Mar 22 doi: 10.1371/journal.pone.0173596. PMID: 28328938Free PMC Article
Gong ZH, Ji JF, Yang J, Xiang T, Zhou CK, Pan XL, Yao J
Kaohsiung J Med Sci 2017 Jan;33(1):24-29. Epub 2016 Dec 9 doi: 10.1016/j.kjms.2016.10.013. PMID: 28088270
Liu P, Zhang HM, Tang YJ, Sheng CF, Liu JX, Zeng YJ
Bratisl Lek Listy 2015;116(3):150-3. PMID: 25869561

Therapy

Hichert V, Scholl C, Steffens M, Paul T, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kächele V, Seufferlein T, Stingl J
Oncotarget 2017 May 23;8(21):35193-35204. doi: 10.18632/oncotarget.17060. PMID: 28456787Free PMC Article
Franchini M, Coppola A, Mengoli C, Rivolta GF, Riccardi F, Minno GD, Tagliaferri A; ad hoc Study Group.
Semin Thromb Hemost 2017 Feb;43(1):69-74. Epub 2016 Nov 8 doi: 10.1055/s-0036-1592166. PMID: 27825181
Li W, Chen W, Xie M, Huang H, Su H, Han H, Zhang D, Zhang Y, Yang X, Xu W, Su Y, Wu W, Huang Y, Fu K, Wei J
Ren Fail 2016 Oct;38(9):1359-1363. Epub 2016 Oct 19 doi: 10.1080/0886022X.2016.1214053. PMID: 27756191
Smith SL, Eyre S, Yarwood A, Hyrich K, Morgan AW, Wilson AG, Isaacs J; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate 6., Plant D, Barton A
Arthritis Res Ther 2015 Dec 14;17:359. doi: 10.1186/s13075-015-0868-y. PMID: 26667261Free PMC Article
Huang Y, Shen L, Cai A, Xiao J
J Tradit Chin Med 2015 Oct;35(5):571-6. PMID: 26591688

Prognosis

Hichert V, Scholl C, Steffens M, Paul T, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kächele V, Seufferlein T, Stingl J
Oncotarget 2017 May 23;8(21):35193-35204. doi: 10.18632/oncotarget.17060. PMID: 28456787Free PMC Article
Pieters M, Barnard SA, Loots DT, Rijken DC
PLoS One 2017;12(2):e0171271. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0171271. PMID: 28158230Free PMC Article
Gong ZH, Ji JF, Yang J, Xiang T, Zhou CK, Pan XL, Yao J
Kaohsiung J Med Sci 2017 Jan;33(1):24-29. Epub 2016 Dec 9 doi: 10.1016/j.kjms.2016.10.013. PMID: 28088270
Li W, Chen W, Xie M, Huang H, Su H, Han H, Zhang D, Zhang Y, Yang X, Xu W, Su Y, Wu W, Huang Y, Fu K, Wei J
Ren Fail 2016 Oct;38(9):1359-1363. Epub 2016 Oct 19 doi: 10.1080/0886022X.2016.1214053. PMID: 27756191
Smith SL, Eyre S, Yarwood A, Hyrich K, Morgan AW, Wilson AG, Isaacs J; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate 6., Plant D, Barton A
Arthritis Res Ther 2015 Dec 14;17:359. doi: 10.1186/s13075-015-0868-y. PMID: 26667261Free PMC Article

Clinical prediction guides

Bobkov VA, Tikhonov RV, Shuster AM, Poteryaev DA, Bade VN
J Interferon Cytokine Res 2017 Jul;37(7):325-329. Epub 2017 Jun 1 doi: 10.1089/jir.2016.0114. PMID: 28570146
Ohashi A, Murata A, Cho Y, Ichinose S, Sakamaki Y, Nishio M, Hoshi O, Fischer S, Preissner KT, Koyama T
PLoS One 2017;12(3):e0174237. Epub 2017 Mar 22 doi: 10.1371/journal.pone.0174237. PMID: 28329009Free PMC Article
Gong ZH, Ji JF, Yang J, Xiang T, Zhou CK, Pan XL, Yao J
Kaohsiung J Med Sci 2017 Jan;33(1):24-29. Epub 2016 Dec 9 doi: 10.1016/j.kjms.2016.10.013. PMID: 28088270
Smith SL, Eyre S, Yarwood A, Hyrich K, Morgan AW, Wilson AG, Isaacs J; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate 6., Plant D, Barton A
Arthritis Res Ther 2015 Dec 14;17:359. doi: 10.1186/s13075-015-0868-y. PMID: 26667261Free PMC Article
Hansson KM, Nielsen S, Elg M, Deinum J
J Thromb Haemost 2014 Oct;12(10):1678-86. Epub 2014 Sep 30 doi: 10.1111/jth.12707. PMID: 25142753

Recent systematic reviews

Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Yuan JQ, Zhang YL, Li HT, Mao C
Medicine (Baltimore) 2017 Feb;96(7):e6151. doi: 10.1097/MD.0000000000006151. PMID: 28207548Free PMC Article
Dennis J, Truong V, Aïssi D, Medina-Rivera A, Blankenberg S, Germain M, Lemire M, Antounians L, Civelek M, Schnabel R, Wells P, Wilson MD, Morange PE, Trégouët DA, Gagnon F
J Thromb Haemost 2016 Oct;14(10):1960-1970. Epub 2016 Sep 17 doi: 10.1111/jth.13431. PMID: 27490645
Romanov V, Marcucci M, Cheng J, Thabane L, Iorio A
Thromb Haemost 2015 Jul;114(1):56-64. Epub 2015 May 28 doi: 10.1160/TH14-10-0882. PMID: 26017627
Gouw SC, van den Berg HM, Oldenburg J, Astermark J, de Groot PG, Margaglione M, Thompson AR, van Heerde W, Boekhorst J, Miller CH, le Cessie S, van der Bom JG
Blood 2012 Mar 22;119(12):2922-34. Epub 2012 Jan 26 doi: 10.1182/blood-2011-09-379453. PMID: 22282501

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