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Items: 1 to 20 of 76

1.

Hyperplasia

An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement. [from NCI]

MedGen UID:
43784
Concept ID:
C0020507
Pathologic Function
2.

Congenital adrenal hyperplasia

A type of adrenal hyperplasia with congenital onset. [from HPO]

MedGen UID:
506200
Concept ID:
CN007259
Finding
3.

Adrenal hyperplasia

A congenital or acquired hyperplasia of the cells of the adrenal cortex or medulla. [from NCI]

MedGen UID:
301220
Concept ID:
C1621895
Disease or Syndrome
4.

Congenital adrenal hyperplasia

A genetic disorder characterized by defects in the synthesis of cortisol and/or aldosterone, resulting in hyperplasia of the adrenal cortical cells. [from NCI]

MedGen UID:
7900
Concept ID:
C0001627
Disease or Syndrome
5.

N 30

MedGen UID:
173771
Concept ID:
C0632490
Organic Chemical; Pharmacologic Substance
6.

Frequency

MedGen UID:
91210
Concept ID:
C0376249
Temporal Concept
7.

Cortisone acetate

The acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adrenal glands with anti-inflammatory and immunomodulating properties. Cortisone acetate diffuses through the cell membrane and binds to nuclear glucocorticoid receptors. The receptor-ligand complex binds to promotor regions of certain genes and initiates RNA transcription. This results in an induction of synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. [from NCI]

MedGen UID:
63861
Concept ID:
C0056391
Hormone; Organic Chemical; Pharmacologic Substance
8.

Prolactin

A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate. [from MeSH]

MedGen UID:
46130
Concept ID:
C0033371
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
9.

Vitamin D preparation

A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE. [from MeSH]

MedGen UID:
22670
Concept ID:
C0042866
Organic Chemical; Pharmacologic Substance; Vitamin
10.

Osteopenia

Osteopenia refers to a reduction in bone mineral density (BMD) below normal peak BMD but not low enough to be classified as osteoporosis. According to the WHO, osteopenia is characterized by a value of BMD more than 1 standard deviation below the young adult mean, but less than 2 standard deviations below this value. [from HPO]

MedGen UID:
18222
Concept ID:
C0029453
Disease or Syndrome; Finding
11.

Generalized osteoporosis

A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss). [from NCI]

MedGen UID:
14535
Concept ID:
C0029456
Disease or Syndrome
12.

Prednisolone

A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. [from MeSH]

MedGen UID:
10892
Concept ID:
C0032950
Organic Chemical; Pharmacologic Substance
13.

Hydrocortisone

A synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. (NCI04) [from NCI]

MedGen UID:
9337
Concept ID:
C0020268
Hormone; Organic Chemical; Pharmacologic Substance
14.

Diagnosis

The determination of the nature of a disease or condition, or the distinguishing of one disease or condition from another. Assessment may be made through physical examination, laboratory tests, or the likes. Computerized programs may be used to enhance the decision-making process. [from MeSH]

MedGen UID:
8354
Concept ID:
C0011900
Finding
15.

Androgenic preparation

A synthetic or animal-derived hormone that is chemically or functionally similar or identical to endogenous androgen with potential use in therapeutic applications. [from NCI]

MedGen UID:
8060
Concept ID:
C0002844
Hormone; Pharmacologic Substance
16.

Cortisone

A corticosteroid with potent glucocorticoid activity. Therapeutic cortisone is the inactive precursor molecule of the active hormone cortisol, which is the hydroxylation product of cortisone by 11-beta-steroid dehydrogenase. Cortisol increases blood pressure and blood sugar levels, and suppresses the immune system, therefore cortisone is used to treat allergies or inflammation. [from NCI]

MedGen UID:
1145
Concept ID:
C0010137
Hormone; Organic Chemical; Pharmacologic Substance
17.

Osteoporosis

MedGen UID:
776590
Concept ID:
C2911643
Finding
18.

21-hydroxylase deficiency

21-hydroxylase deficiency (21-OHD) is the most common cause of congenital adrenal hyperplasia (CAH), a family of autosomal recessive disorders involving impaired synthesis of cortisol from cholesterol by the adrenal cortex. In 21-OHD CAH, excessive adrenal androgen biosynthesis results in virilization in all individuals and salt wasting in some individuals. A classic form with severe enzyme deficiency and prenatal onset of virilization is distinguished from a non-classic form with mild enzyme deficiency and postnatal onset. The classic form is further divided into the simple virilizing form (~25% of affected individuals) and the salt-wasting form, in which aldosterone production is inadequate (=75% of individuals). Newborns with salt-wasting 21-OHD CAH are at risk for life-threatening salt-wasting crises. Individuals with the non-classic form of 21-OHD CAH present postnatally with signs of hyperandrogenism; females with the non-classic form are not virilized at birth. [from GTR]

MedGen UID:
468578
Concept ID:
C0852654
Disease or Syndrome
19.

Acetate compound

Salt or ester form of acetic acid. Acetate is the most common building block for biosynthesis, such as fatty acids. [from NCI]

MedGen UID:
452099
Concept ID:
C0000975
Organic Chemical; Pharmacologic Substance
20.

Vitamin, Other

Organic substances belonging to diverse chemical families and present in foods in minute amounts, Vitamins are essential to normal metabolism and biochemical functions, usually as coenzymes. Vitamins can be classified by solubility: lipo-soluble (vitamins A, D, E, K, F) and water-soluble (B- complex). Lack of one or more vitamins in the diet cause metabolic deficiency diseases. (NCI04) [from NCI]

MedGen UID:
203015
Concept ID:
C0973669
Organic Chemical; Pharmacologic Substance; Vitamin
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