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Hand skill, relative(HSR)

MedGen UID:
330665
Concept ID:
C1841691
Disease or Syndrome; Gene or Genome
Synonyms: HANDEDNESS; HSR
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
892334
Concept ID:
CN000007
Functional Concept
Source: HPO
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
 
OMIM®: 139900

Recent clinical studies

Etiology

Sreedharan RM, Menon AC, James JS, Kesavadas C, Thomas SV
Neuroradiology 2015 Mar;57(3):291-7. Epub 2014 Dec 3 doi: 10.1007/s00234-014-1469-1. PMID: 25467219
Karádi K, Lucza T, Aschermann Z, Komoly S, Deli G, Bosnyák E, Acs P, Horváth R, Janszky J, Kovács N
Laterality 2015;20(1):112-27. Epub 2014 Jul 10 doi: 10.1080/1357650X.2014.936444. PMID: 25341015
Reissland N, Aydin E, Francis B, Exley K
Laterality 2015;20(1):82-94. Epub 2014 Jun 3 doi: 10.1080/1357650X.2014.920339. PMID: 24889397
Barron DS, Fox PT, Pardoe H, Lancaster J, Price LR, Blackmon K, Berry K, Cavazos JE, Kuzniecky R, Devinsky O, Thesen T
Neuroimage Clin 2014 Aug 7;7:273-80. doi: 10.1016/j.nicl.2014.08.002. PMID: 25610790Free PMC Article
Løberg EM, Jørgensen HA, Green MF, Rund BR, Lund A, Diseth A, Oie M, Hugdahl K
Acta Psychiatr Scand 2006 Apr;113(4):322-31. doi: 10.1111/j.1600-0447.2005.00627.x. PMID: 16638077

Diagnosis

Sreedharan RM, Menon AC, James JS, Kesavadas C, Thomas SV
Neuroradiology 2015 Mar;57(3):291-7. Epub 2014 Dec 3 doi: 10.1007/s00234-014-1469-1. PMID: 25467219
Barron DS, Fox PT, Pardoe H, Lancaster J, Price LR, Blackmon K, Berry K, Cavazos JE, Kuzniecky R, Devinsky O, Thesen T
Neuroimage Clin 2014 Aug 7;7:273-80. doi: 10.1016/j.nicl.2014.08.002. PMID: 25610790Free PMC Article
Denny K
Neuropsychologia 2008;46(7):2091-4. Epub 2008 Feb 9 doi: 10.1016/j.neuropsychologia.2008.02.004. PMID: 18342341
Savitz J, van der Merwe L, Solms M, Ramesar R
Genes Brain Behav 2007 Nov;6(8):698-705. Epub 2007 Feb 16 doi: 10.1111/j.1601-183X.2006.00299.x. PMID: 17309660
Løberg EM, Jørgensen HA, Green MF, Rund BR, Lund A, Diseth A, Oie M, Hugdahl K
Acta Psychiatr Scand 2006 Apr;113(4):322-31. doi: 10.1111/j.1600-0447.2005.00627.x. PMID: 16638077

Therapy

Batens K, De Letter M, Raedt R, Duyck W, Vanhoutte S, Van Roost D, Santens P
Brain Lang 2015 Aug;147:76-84. Epub 2015 Jun 19 doi: 10.1016/j.bandl.2015.06.002. PMID: 26099950
Heyer EJ, Mallon KA, Mergeche JL, Stern Y, Connolly ES
J Neurosurg 2015 Jan;122(1):101-6. doi: 10.3171/2014.8.JNS1459. PMID: 25343190
Oertel V, Knöchel C, Rotarska-Jagiela A, Schönmeyer R, Lindner M, van de Ven V, Haenschel C, Uhlhaas P, Maurer K, Linden DE
J Neurosci 2010 Feb 10;30(6):2289-99. doi: 10.1523/JNEUROSCI.4575-09.2010. PMID: 20147555
Hori H, Ozeki Y, Terada S, Kunugi H
Prog Neuropsychopharmacol Biol Psychiatry 2008 Dec 12;32(8):1944-51. Epub 2008 Oct 1 doi: 10.1016/j.pnpbp.2008.09.019. PMID: 18929612
Hiscock M, Caroselli JS, Wood S
Cortex 2006 Jan;42(1):38-47. PMID: 16509107

Prognosis

Voyer SD, Voyer D
J Clin Exp Neuropsychol 2015;37(1):27-36. Epub 2015 Jan 6 doi: 10.1080/13803395.2014.985191. PMID: 25562410
Barron DS, Fox PT, Pardoe H, Lancaster J, Price LR, Blackmon K, Berry K, Cavazos JE, Kuzniecky R, Devinsky O, Thesen T
Neuroimage Clin 2014 Aug 7;7:273-80. doi: 10.1016/j.nicl.2014.08.002. PMID: 25610790Free PMC Article
Rempala DM
Laterality 2014;19(3):256-77. Epub 2013 May 16 doi: 10.1080/1357650X.2013.794146. PMID: 23678889
Denny K
Neuropsychologia 2008;46(7):2091-4. Epub 2008 Feb 9 doi: 10.1016/j.neuropsychologia.2008.02.004. PMID: 18342341
Løberg EM, Jørgensen HA, Green MF, Rund BR, Lund A, Diseth A, Oie M, Hugdahl K
Acta Psychiatr Scand 2006 Apr;113(4):322-31. doi: 10.1111/j.1600-0447.2005.00627.x. PMID: 16638077

Clinical prediction guides

Bellana B, Liu Z, Anderson JA, Moscovitch M, Grady CL
Neuropsychologia 2016 Jan 8;80:24-34. Epub 2015 Nov 10 doi: 10.1016/j.neuropsychologia.2015.11.004. PMID: 26559474
Mellet E, Jobard G, Zago L, Crivello F, Petit L, Joliot M, Mazoyer B, Tzourio-Mazoyer N
Laterality 2014;19(4):383-404. Epub 2013 Jun 7 doi: 10.1080/1357650X.2013.796965. PMID: 23745714
Rempala DM
Laterality 2014;19(3):256-77. Epub 2013 May 16 doi: 10.1080/1357650X.2013.794146. PMID: 23678889
Denny K
Neuropsychologia 2008;46(7):2091-4. Epub 2008 Feb 9 doi: 10.1016/j.neuropsychologia.2008.02.004. PMID: 18342341
Savitz J, van der Merwe L, Solms M, Ramesar R
Genes Brain Behav 2007 Nov;6(8):698-705. Epub 2007 Feb 16 doi: 10.1111/j.1601-183X.2006.00299.x. PMID: 17309660

Recent systematic reviews

Sandars M, Cloutman L, Woollams AM
Neural Plast 2016;2016:8428256. Epub 2015 Dec 27 doi: 10.1155/2016/8428256. PMID: 26819777Free PMC Article
Brandler WM, Morris AP, Evans DM, Scerri TS, Kemp JP, Timpson NJ, St Pourcain B, Smith GD, Ring SM, Stein J, Monaco AP, Talcott JB, Fisher SE, Webber C, Paracchini S
PLoS Genet 2013;9(9):e1003751. Epub 2013 Sep 12 doi: 10.1371/journal.pgen.1003751. PMID: 24068947Free PMC Article
Crow TJ, Chance SA, Priddle TH, Radua J, James AC
Psychiatry Res 2013 Dec 30;210(3):1232-44. Epub 2013 Sep 6 doi: 10.1016/j.psychres.2013.07.043. PMID: 24011847
Voyer D, Voyer SD, Tramonte L
Neuropsychology 2012 Sep;26(5):551-67. Epub 2012 Jun 25 doi: 10.1037/a0028631. PMID: 22731609
Voyer D, Doyle RA
Laterality 2012;17(3):259-74. Epub 2011 Jul 19 doi: 10.1080/1357650X.2011.568487. PMID: 22594810

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