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Items: 4

1.

Microbicides, Topical

Generically, any topical agent that destroys microbes. However, usage of the term is increasingly being confined to topical agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES. [from MeSH]

MedGen UID:
209728
Concept ID:
C1136255
Pharmacologic Substance
2.

Resiquimod

An imidazoquinolinamine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines, especially interferon-alpha (INF-a) and other cytokines, thereby enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans' cells, leading to an enhanced activation of T-lymphocytes. Due to its immunostimulatory activity, this agent may potentially be useful as a vaccine adjuvant. [from NCI]

MedGen UID:
197605
Concept ID:
C0965594
Organic Chemical; Pharmacologic Substance
3.

Skin lesions

MedGen UID:
508146
Concept ID:
C0037284
Disease or Syndrome
4.

Neoplasm of the skin

A primary or metastatic tumor involving the skin. Primary malignant skin tumors most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or melanomas that arise from pigment-containing skin melanocytes. Metastatic tumors to the skin include carcinomas and lymphomas. [from NCI]

MedGen UID:
40101
Concept ID:
C0007114
Neoplastic Process
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