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Items: 4

1.

Metoprolol succinate

The succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol succinate antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thus decreasing sympathetic activation, including vasoconstriction, aldosterone secretion. [from NCI]

MedGen UID:
147482
Concept ID:
C0724633
Organic Chemical; Pharmacologic Substance
2.

Telmisartan

A benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure. [from NCI]

MedGen UID:
117569
Concept ID:
C0248719
Organic Chemical; Pharmacologic Substance
3.

Succinate

MedGen UID:
67427
Concept ID:
C0220918
Organic Chemical; Pharmacologic Substance
4.

Metoprolol

A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion. [from NCI]

MedGen UID:
10011
Concept ID:
C0025859
Organic Chemical; Pharmacologic Substance
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