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Items: 14

1.

Docetaxel

A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04) [from NCI]

MedGen UID:
70063
Concept ID:
C0246415
Organic Chemical; Pharmacologic Substance
2.

Neutropenic disorder

A decrease in the number of NEUTROPHILS found in the blood. [from MeSH]

MedGen UID:
18030
Concept ID:
C0027947
Disease or Syndrome
3.

Neutropenia

A decrease in the number of neutrophils in the peripheral blood. [from NCI]

MedGen UID:
163121
Concept ID:
C0853697
Finding
4.

Cancer

An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumour). [from HPO]

MedGen UID:
14297
Concept ID:
C0006826
Neoplastic Process
5.

Related

MedGen UID:
619805
Concept ID:
C0445223
Finding
6.

taxane

MedGen UID:
67116
Concept ID:
C0215136
Organic Chemical; Pharmacologic Substance
7.

Granulocytopenia

A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS). [from MeSH]

MedGen UID:
7932
Concept ID:
C0001824
Disease or Syndrome
8.

White blood cell disorder

Disordered formation of various types of leukocytes or an abnormal accumulation or deficiency of these cells. [from MeSH]

MedGen UID:
7325
Concept ID:
C0023510
Disease or Syndrome
9.

Heredity

The transmission of traits encoded in GENES from parent to offspring. [from MeSH]

MedGen UID:
6814
Concept ID:
C0019266
Molecular Function
10.

Hemic and Lymphatic Diseases

Hematologic diseases and diseases of the lymphatic system collectively. Hemic diseases include disorders involving the formed elements (e.g., ERYTHROCYTE AGGREGATION, INTRAVASCULAR) and chemical components (e.g., BLOOD PROTEIN DISORDERS); lymphatic diseases include disorders relating to lymph, lymph nodes, and lymphocytes. [from MeSH]

MedGen UID:
6780
Concept ID:
C0018981
Disease or Syndrome
11.

Leukopenia

A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000). [from MeSH]

MedGen UID:
6073
Concept ID:
C0023530
Disease or Syndrome
12.

Hematologic disease

An abnormality of the hematopoietic system. [from HPO]

MedGen UID:
5483
Concept ID:
C0018939
Disease or Syndrome
13.

Antineoplastic agent

A substance that inhibits the maturation, growth or spread of tumor cells. [from NCI]

MedGen UID:
1984
Concept ID:
C0003392
Organic Chemical; Pharmacologic Substance
14.

Metabolic neutropenia

MedGen UID:
584948
Concept ID:
C0398584
Disease or Syndrome
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