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Separation anxiety

MedGen UID:
1999
Concept ID:
C0003477
Mental or Behavioral Dysfunction
Synonyms: Anxiety Disorder, Separation; Anxiety, Separation; Separation Anxiety; Separation Anxiety Disorder
SNOMED CT: Separation anxiety (126943008); Separation anxiety disorder (11806006)
 

Definition

Anxiety experienced by an individual upon separation from a person or object of particular significance to the individual. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSeparation anxiety

Recent clinical studies

Etiology

Tasdemir A, Tamam L, Keskin N, Evlice YE
Nord J Psychiatry 2016;70(2):93-102. Epub 2015 Jun 24 doi: 10.3109/08039488.2015.1053098. PMID: 26107408
Busch FN, Milrod BL
J Am Psychoanal Assoc 2015 Oct;63(5):893-919. doi: 10.1177/0003065115607491. PMID: 26487108
Silove D, Alonso J, Bromet E, Gruber M, Sampson N, Scott K, Andrade L, Benjet C, Caldas de Almeida JM, De Girolamo G, de Jonge P, Demyttenaere K, Fiestas F, Florescu S, Gureje O, He Y, Karam E, Lepine JP, Murphy S, Villa-Posada J, Zarkov Z, Kessler RC
Am J Psychiatry 2015 Jul;172(7):647-56. Epub 2015 Jun 5 doi: 10.1176/appi.ajp.2015.14091185. PMID: 26046337Free PMC Article
Redlich R, Grotegerd D, Opel N, Kaufmann C, Zwitserlood P, Kugel H, Heindel W, Donges US, Suslow T, Arolt V, Dannlowski U
Soc Cogn Affect Neurosci 2015 Feb;10(2):278-84. Epub 2014 Apr 20 doi: 10.1093/scan/nsu055. PMID: 24752071Free PMC Article
Silove D, Rees S
Asian J Psychiatr 2014 Oct;11:98-101. Epub 2014 Jul 2 doi: 10.1016/j.ajp.2014.06.021. PMID: 25453710

Diagnosis

Lebowitz ER, Leckman JF, Feldman R, Zagoory-Sharon O, McDonald N, Silverman WK
Psychoneuroendocrinology 2016 Mar;65:35-43. Epub 2015 Dec 14 doi: 10.1016/j.psyneuen.2015.12.007. PMID: 26716876Free PMC Article
Tasdemir A, Tamam L, Keskin N, Evlice YE
Nord J Psychiatry 2016;70(2):93-102. Epub 2015 Jun 24 doi: 10.3109/08039488.2015.1053098. PMID: 26107408
Silove D, Alonso J, Bromet E, Gruber M, Sampson N, Scott K, Andrade L, Benjet C, Caldas de Almeida JM, De Girolamo G, de Jonge P, Demyttenaere K, Fiestas F, Florescu S, Gureje O, He Y, Karam E, Lepine JP, Murphy S, Villa-Posada J, Zarkov Z, Kessler RC
Am J Psychiatry 2015 Jul;172(7):647-56. Epub 2015 Jun 5 doi: 10.1176/appi.ajp.2015.14091185. PMID: 26046337Free PMC Article
Silove D, Rees S
Asian J Psychiatr 2014 Oct;11:98-101. Epub 2014 Jul 2 doi: 10.1016/j.ajp.2014.06.021. PMID: 25453710
Pini S, Abelli M, Troisi A, Siracusano A, Cassano GB, Shear KM, Baldwin D
J Anxiety Disord 2014 Dec;28(8):741-6. Epub 2014 Jul 11 doi: 10.1016/j.janxdis.2014.06.010. PMID: 25218272

Therapy

Milrod B, Altemus M, Gross C, Busch F, Silver G, Christos P, Stieber J, Schneier F
Compr Psychiatry 2016 Apr;66:139-45. Epub 2016 Jan 22 doi: 10.1016/j.comppsych.2016.01.004. PMID: 26995247
Pozzi G, Bruschi A, De Angelis A, Pascucci M, Hatzigiakoumis DS, Grandinetti P, Di Nicola M, Pini S, Janiri L
Biomed Res Int 2014;2014:680985. Epub 2014 Jul 3 doi: 10.1155/2014/680985. PMID: 25105134Free PMC Article
Golubchik P, Golubchik L, Sever JM, Weizman A
Int Clin Psychopharmacol 2014 Sep;29(5):274-8. doi: 10.1097/YIC.0000000000000034. PMID: 24743562
Kossowsky J, Pfaltz MC, Schneider S, Taeymans J, Locher C, Gaab J
Am J Psychiatry 2013 Jul;170(7):768-81. doi: 10.1176/appi.ajp.2012.12070893. PMID: 23680783
Schneider S, Blatter-Meunier J, Herren C, In-Albon T, Adornetto C, Meyer A, Lavallee KL
J Consult Clin Psychol 2013 Oct;81(5):932-40. Epub 2013 Apr 22 doi: 10.1037/a0032678. PMID: 23607501

Prognosis

Tasdemir A, Tamam L, Keskin N, Evlice YE
Nord J Psychiatry 2016;70(2):93-102. Epub 2015 Jun 24 doi: 10.3109/08039488.2015.1053098. PMID: 26107408
Ben-Israel Y, Shadach E, Levy S, Sperber A, Aizenberg D, Niv Y, Dickman R
Stress Health 2016 Dec;32(5):463-471. Epub 2015 Jun 1 doi: 10.1002/smi.2642. PMID: 26033751
Tay AK, Rees S, Chen J, Kareth M, Silove D
J Anxiety Disord 2015 Oct;35:1-8. Epub 2015 Jul 22 doi: 10.1016/j.janxdis.2015.07.001. PMID: 26275507
Kohlhoff J, Barnett B, Eapen V
Compr Psychiatry 2015 Aug;61:1-9. Epub 2015 May 14 doi: 10.1016/j.comppsych.2015.05.004. PMID: 26094158
Silove D, Alonso J, Bromet E, Gruber M, Sampson N, Scott K, Andrade L, Benjet C, Caldas de Almeida JM, De Girolamo G, de Jonge P, Demyttenaere K, Fiestas F, Florescu S, Gureje O, He Y, Karam E, Lepine JP, Murphy S, Villa-Posada J, Zarkov Z, Kessler RC
Am J Psychiatry 2015 Jul;172(7):647-56. Epub 2015 Jun 5 doi: 10.1176/appi.ajp.2015.14091185. PMID: 26046337Free PMC Article

Clinical prediction guides

Milrod B, Altemus M, Gross C, Busch F, Silver G, Christos P, Stieber J, Schneier F
Compr Psychiatry 2016 Apr;66:139-45. Epub 2016 Jan 22 doi: 10.1016/j.comppsych.2016.01.004. PMID: 26995247
Lebowitz ER, Leckman JF, Feldman R, Zagoory-Sharon O, McDonald N, Silverman WK
Psychoneuroendocrinology 2016 Mar;65:35-43. Epub 2015 Dec 14 doi: 10.1016/j.psyneuen.2015.12.007. PMID: 26716876Free PMC Article
Silove D, Alonso J, Bromet E, Gruber M, Sampson N, Scott K, Andrade L, Benjet C, Caldas de Almeida JM, De Girolamo G, de Jonge P, Demyttenaere K, Fiestas F, Florescu S, Gureje O, He Y, Karam E, Lepine JP, Murphy S, Villa-Posada J, Zarkov Z, Kessler RC
Am J Psychiatry 2015 Jul;172(7):647-56. Epub 2015 Jun 5 doi: 10.1176/appi.ajp.2015.14091185. PMID: 26046337Free PMC Article
Redlich R, Grotegerd D, Opel N, Kaufmann C, Zwitserlood P, Kugel H, Heindel W, Donges US, Suslow T, Arolt V, Dannlowski U
Soc Cogn Affect Neurosci 2015 Feb;10(2):278-84. Epub 2014 Apr 20 doi: 10.1093/scan/nsu055. PMID: 24752071Free PMC Article
Golubchik P, Golubchik L, Sever JM, Weizman A
Int Clin Psychopharmacol 2014 Sep;29(5):274-8. doi: 10.1097/YIC.0000000000000034. PMID: 24743562

Recent systematic reviews

Kossowsky J, Pfaltz MC, Schneider S, Taeymans J, Locher C, Gaab J
Am J Psychiatry 2013 Jul;170(7):768-81. doi: 10.1176/appi.ajp.2012.12070893. PMID: 23680783
Scaini S, Ogliari A, Eley TC, Zavos HM, Battaglia M
Depress Anxiety 2012 Sep;29(9):754-61. Epub 2012 Apr 11 doi: 10.1002/da.21941. PMID: 22496044
Shear K, Jin R, Ruscio AM, Walters EE, Kessler RC
Am J Psychiatry 2006 Jun;163(6):1074-83. doi: 10.1176/ajp.2006.163.6.1074. PMID: 16741209Free PMC Article
Manicavasagar V, Silove D, Curtis J
Compr Psychiatry 1997 Sep-Oct;38(5):274-82. PMID: 9298320
Silove D, Manicavasagar V, Curtis J, Blaszczynski A
Compr Psychiatry 1996 May-Jun;37(3):167-79. PMID: 8732584

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