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1.

Lymphoma

Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas. Non-Hodgkin lymphomas begin when a type of white blood cell, called a T cell or B cell, becomes abnormal. The cell divides again and again, making more and more abnormal cells. These abnormal cells can spread to almost any other part of the body. Most of the time, doctors don't know why a person gets non-Hodgkin lymphoma. You are at increased risk if you have a weakened immune system or have certain types of infections. Non-Hodgkin lymphoma can cause many symptoms, such as . -Swollen, painless lymph nodes in the neck, armpits or groin. -Unexplained weight loss . -Fever . -Soaking night sweats . -Coughing, trouble breathing or chest pain . -Weakness and tiredness that don't go away . -Pain, swelling or a feeling of fullness in the abdomen . Your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. Treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. Targeted therapy uses substances that attack cancer cells without harming normal cells. Biologic therapy boosts your body's own ability to fight cancer. If you don't have symptoms, you may not need treatment right away. This is called watchful waiting. NIH: National Cancer Institute.  [from MedlinePlus]

MedGen UID:
44223
Concept ID:
C0024299
Neoplastic Process
2.

Grade 2 Follicular Lymphoma

A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field. [from NCI]

MedGen UID:
42543
Concept ID:
C0079758
Neoplastic Process
3.

Lymphoma

A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells. [from HPO]

MedGen UID:
505322
Concept ID:
CN002422
Finding
4.

Follicular lymphoma

A neoplasm of lymphoid cells which has at least a partial follicular pattern. [from NCI]

MedGen UID:
7417
Concept ID:
C0024301
Neoplastic Process
5.

Male gender

A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. (NCI) [from NCI]

MedGen UID:
7446
Concept ID:
C0024554
Finding; Organism Attribute
6.

Absence

MedGen UID:
739164
Concept ID:
C1689985
Anatomical Abnormality
7.

3/6

MedGen UID:
617757
Concept ID:
C0442759
Finding
8.

Detected

The measurement of the specified component / analyte, organism or clinical sign above the limit of detection of the performed test or procedure.  [from HL7]

MedGen UID:
617726
Concept ID:
C0442726
Finding
9.

Clonal Immunoglobulin Gene Rearrangement

A DNA sequence rearrangement that results in the creation of a novel immunoglobulin. This process occurs during the differentiation of B-lymphocytes, such that individual B-cell progenitors, and their descendents, express an identical antibody molecule. [from NCI]

MedGen UID:
273183
Concept ID:
C1516672
Cell or Molecular Dysfunction
10.

Proliferation

Growth and reproduction of new similar forms, e.g. cells, buds, or offspring. [from NCI]

MedGen UID:
137720
Concept ID:
C0334094
Functional Concept; Pathologic Function
11.

Immunoglobulins

there are two types of polypeptide chains responsible for the biological and immunological properties of the different immunoglobulins, the heavy chain and the light chain; they are linked by covalent and non-covalent forces to give a four-chain Y-shaped structure based on pairs of identical heavy and light chains; each chain consists of a variable region and a constant region which are coded for by different genes; some immunoglobulin classes occur as polymers of this basic monomer. [from CRISP]

MedGen UID:
43841
Concept ID:
C0021027
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
12.

Lymphosarcoma

An antiquated term referring to non-Hodgkin lymphomas composed of small and medium sized lymphocytes. [from NCI]

MedGen UID:
811370
Concept ID:
C3714542
Neoplastic Process
13.

Lymphatism

MedGen UID:
141817
Concept ID:
C0524631
Disease or Syndrome
14.

Diffuse non-Hodgkin lymphoma, undifferentiated

MedGen UID:
44226
Concept ID:
C0024306
Neoplastic Process
15.

Mixed Cell Lymphoma

An antiquated term that refers to a lymphoma composed of a mixture of small and large lymphocytes. [from NCI]

MedGen UID:
44225
Concept ID:
C0024304
Neoplastic Process
16.

Diffuse Mixed Cell Lymphoma

An antiquated term referring to non-Hodgkin lymphomas with a mixed cellular composition. This term applies to both B- and T- cell non-Hodgkin lymphomas. [from NCI]

MedGen UID:
42542
Concept ID:
C0079757
Neoplastic Process
17.

Low Grade Lymphoma

A type of lymphoma that tends to grow and spread slowly, and has few symptoms. Also called indolent lymphoma. [from NCI]

MedGen UID:
42540
Concept ID:
C0079747
Neoplastic Process
18.

Intermediate Grade Lymphoma

A type of lymphoma that grows and spreads quickly and has severe symptoms. Also called aggressive lymphoma and high-grade lymphoma. [from NCI]

MedGen UID:
38239
Concept ID:
C0079741
Neoplastic Process
19.

High Grade Lymphoma

A type of lymphoma that grows and spreads quickly and has severe symptoms. Also called aggressive lymphoma and intermediate-grade lymphoma. [from NCI]

MedGen UID:
38238
Concept ID:
C0079740
Neoplastic Process
20.

Lymphoma, Large-Cell, Follicular

A follicular lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field. [from NCI]

MedGen UID:
36334
Concept ID:
C0079745
Neoplastic Process
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